Citation: Yating Zheng, Yulan Huang, Jing Luo, Xuqi Peng, Xiran Gui, Gang Liu, Yang Zhang. Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application[J]. Chinese Chemical Letters, ;2024, 35(7): 109169. doi: 10.1016/j.cclet.2023.109169 shu

Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Yating Zheng ^{a, 1} ,
Yulan Huang ^{a, 1} ,
Jing Luo ^{c, 1} ,
Xuqi Peng ^a ,
Xiran Gui ^a ,
Gang Liu ^{a, d, *,} ,
Yang Zhang ^{a, b, *,}

a.
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b.
Shen Zhen Research Institute of Xiamen University, Shenzhen 518057, China
c.
Division of Urology and Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States
d.
Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361102, China

gangliu.cmitm@xmu.edu.cn

zhangyang0823@xmu.edu.cn

Received Date: 15 June 2023
Revised Date: 2 October 2023
Accepted Date: 5 October 2023
Available Online: 9 October 2023

Figures(4)

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components, good biocompatibility, and high targeting. However, their large relative molecular weight, complex structure, susceptibility to degradation, and poor stability limit their usefulness. Nanotechnology can address these issues by improving the therapeutic value, bioavailability, permeability, and absorption of biomacromolecules while regulating their retention time in the body. Especially, compelling evidence has been reported that supercritical fluid (SCF) technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination. In this review, we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine, and extensively discuss their characteristics and mechanisms. In particular, the protein-based, nucleic acid-based, and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized, and the potential for industrial production of biomacromolecular drugs is also considered. We further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.
- Biomacromolecules,
- Supercritical fluid technology,
- Therapeutic proteins,
- Gene therapy,
- Nanomedicine
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沈阳化工大学材料科学与工程学院沈阳 110142