Citation: Shaomin Chen, Luigi Vaccaro, Yanlong Gu. Recent advances of versatile reagents as controllable building blocks in organic synthesis[J]. Chinese Chemical Letters, ;2024, 35(2): 109152. doi: 10.1016/j.cclet.2023.109152 shu

Recent advances of versatile reagents as controllable building blocks in organic synthesis

Shaomin Chen ^{a, b} ,
Luigi Vaccaro ^b ,
Yanlong Gu ^{a, c, *,}

a.
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
b.
Laboratory of Green S.O.C., Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Via Elce di Sotto 8, Perugia 06123, Italy
c.
School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832004, China

klgyl@hust.edu.cn

Received Date: 28 July 2023
Revised Date: 19 September 2023
Accepted Date: 25 September 2023
Available Online: 27 September 2023

Figures(67)

Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials. To date, diversity-oriented synthesis mostly relies on the employment of versatile reagents. Versatile reagents can be regulated as controllable and flexible building blocks for multipurpose utilizations. Over the past decade, a variety of multifunctional reagents have been developed. However, most versatile reagents usually need multi-step synthesis, thus restricting their wide application to a large extent. In terms of the practicalities and universalities, we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities, mainly including atropaldehyde acetals, aryl methyl ketones, vinylene carbonate, vinyl azides, aryldiazonium salts, rongalite, halodifluoromethyl compounds. Most importantly, these versatile reagents can also play different roles simultaneously in the same reaction, in which their different reactivities are converged into the final target products. Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients, but also minimize the occurrence of some side reactions by lessening the varieties of materials. Also, a perspective is given at the end of this review.
- Versatile reagents,
- Divergent synthesis,
- Dual synthons,
- Bond cleavage,
- Tandem reactions
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沈阳化工大学材料科学与工程学院沈阳 110142