Citation: Qihan Lin, Jiabin Xing, Yue-Yang Liu, Gang Wu, Shi-Jia Liu, Hui Wang, Wei Zhou, Zhan-Ting Li, Dan-Wei Zhang. taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine[J]. Chinese Chemical Letters, ;2024, 35(5): 109119. doi: 10.1016/j.cclet.2023.109119 shu

taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China

ztli@fudan.edu.cn

zhangdw@fudan.edu.cn

Received Date: 18 July 2023
Revised Date: 7 September 2023
Accepted Date: 17 September 2023
Available Online: 19 September 2023

Figures(4)

A water-soluble macrocycle that bears four carboxylate anions has been designed and prepared, which forms a rectangular cavity that can efficiently encapsulate discrete electron-deficient aromatic compounds, including berberine and palmatine. This macrocycle is revealed to be highly biocompatible and able to inhibit the bitter taste of the two drugs.
- Macrocycle,
- Multianion,
- Molecular container,
- Molecular recognition,
- Bitter taste masking
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