Citation: Simin Wei, Yaqing Yang, Junjie Li, Jialin Wang, Jinlu Tang, Ningning Wang, Zhaohui Li. The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite[J]. Chinese Chemical Letters, ;2024, 35(6): 109114. doi: 10.1016/j.cclet.2023.109114 shu

The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite

Simin Wei ^a ,
Yaqing Yang ^a ,
Junjie Li ^a ,
Jialin Wang ^a ,
Jinlu Tang ^b ,
Ningning Wang ^{a, *,} ,
Zhaohui Li ^{a, *,}

a.
College of Chemistry, Institute of Analytical Chemistry for Life Science, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and their Bioanalytical Applications, Zhengzhou University, Zhengzhou 450001, China
b.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China

ningningwang@zzu.edu.cn

zhaohui.li@zzu.edu.cn

Received Date: 13 April 2023
Revised Date: 31 August 2023
Accepted Date: 15 September 2023
Available Online: 18 September 2023

Figures(5)

Long-term excessive intake of nitrite (NO₂⁻) poses a great threat to human health, needing a simple and fast method to detect NO₂⁻ in food. Herein, via a simple and feasible strategy, Mn/Yb/Er triple-doped CeO₂ nanozyme (Mn/Yb/Er/CeO₂) was synthesized for highly sensitive ratiometric detection of nitrite. By doping Mn, Yb, Er into CeO₂ lattice structure, Mn/Yb/Er/CeO₂ nanozyme showed enhanced oxidase-like activity, obtaining a higher density of oxygen vacancy and a higher ratio of Ce³⁺ to Ce⁴⁺ than that of CeO₂. The 3,3′,5,5′-tetramethylbenzidine (TMB) can be effectively oxidized by Mn/Yb/Er/CeO₂ to produce the oxidized TMB (oxTMB), showing a significant absorption signal at 652 nm. Additionally, nitrite can react with oxTMB to produce yellow diazotized oxTMB, which is accompanied by an elevated absorption signal at 445 nm and a decreased absorption signal at 652 nm. Thus, based on the oxidase-mimetic activity of Mn/Yb/Er/CeO₂ and the diazotization reaction between NO₂⁻ and oxTMB, a ratiometric colorimetric assay was established for NO₂⁻ detection in food. Furthermore, by integrating Mn/Yb/Er/CeO₂ with a smartphone, a colorimetric smartphone-sensing platform was successfully fabricated for visualization and quantitative detection of NO₂⁻. Notably, this two-detection mode showed excellent sensitivity, selectivity, reliability and practicability in monitoring the NO₂⁻ in real samples, impling its great potential for food safety.
- Mn/Yb/Er/CeO₂ nanozyme,
- Oxidase-like activity,
- Nitrite,
- Ratiometric detection,
- Two-detection mode
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沈阳化工大学材料科学与工程学院沈阳 110142

The Mn/Yb/Er triple-doped CeO2 nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite

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通讯作者: 陈斌, bchen63@163.com

The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite