Citation: Aimin Fu, Chunmei Chen, Qin Li, Nanjin Ding, Jiaxin Dong, Yu Chen, Mengsha Wei, Weiguang Sun, Hucheng Zhu, Yonghui Zhang. Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans[J]. Chinese Chemical Letters, ;2024, 35(9): 109100. doi: 10.1016/j.cclet.2023.109100 shu

Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

weiguangsun@hust.edu.cn

zhuhucheng@hust.edu.cn

zhangyh@mails.tjmu.edu.cn

Received Date: 21 July 2023
Revised Date: 11 September 2023
Accepted Date: 13 September 2023
Available Online: 16 September 2023

Figures(5)

Niduenes A−F (1−6), six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus nidulans. Compounds 1 and 2 represent the first examples of aromatic pentacyclic sesterterpenoids. Their structures and configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses. Compound 4 demonstrated potent resensitization of SW620/AD300 cells to paclitaxel (PTX). Rhodamine 123 accumulation assay and docking analysis further support that 4 inhibitory the efflux function of P-glycoprotein (P-gp).
- Aspergillus nidulans,
- Sesterterpenoids,
- Aromatic sesterterpenoids,
- Structure elucidation,
- Single-crystal X-ray diffraction,
- Biosynthetic pathways
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