Advancements in life-on-a-chip: The impact of "Beyond Limits Manufacturing" technology

Weiwei He ^{a, 1} ,
Hongbo Zhang ^{b, 1} ,
Xudong Lin ^c ,
Lili Zhu ^a ,
Tingting Zheng ^d ,
Hao Pei ^d ,
Yang Tian ^d ,
Min Zhang ^d ,
Guoyue Shi ^d ,
Lei Wu ^e ,
Jianlong Zhao ^e ,
Gulinuer Wumaier ^f ,
Shengqing Li ^f ,
Yufang Xu ^a ,
Honglin Li ^{a, g, h, *,} ,
Xuhong Qian ^{a, d, g, *,}

a.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
c.
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518000, China
d.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China
e.
Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
f.
Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
g.
Innovation Center for AI and Drug Discovery, East China Normal University, Shanghai 200062, China
h.
Lingang Laboratory, Shanghai 200031, China

hlli@ecust.edu.cn

xhqian@ecnu.edu.cn

Received Date: 10 August 2023
Revised Date: 8 September 2023
Accepted Date: 11 September 2023
Available Online: 21 September 2023

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This review explores the concept of life-on-a-chip, which involves the creation of miniaturized biological systems, such as organs, tissues, and model organisms, on microscale platforms called microfluidic chips. These chips consist of intricately etched channels, wells, and chambers that enable precise control and observation of fluids, cells, and biochemical reactions, facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli, drugs, or disease conditions. The review highlights the application of a novel technology, "Beyond Limit Manufacturing" (BLM), in the development of sophisticated three-dimensional cell models and model organism microchips. Model-organism-on-a-chip and organ-on-a-chip (OoC) are among the thriving developments in the field of microfluidics, allowing for the reconstruction of living microenvironments and implementation of multiple stimuli. The review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions, emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

Advancements in life-on-a-chip: The impact of "Beyond Limits Manufacturing" technology

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