Citation: Shuying Li, Weiwei ZhuGe, Xuan Sun, Chongzhen Sun, Zhaojun Liu, Chenghe Xiong, Min Xiao, Guofeng Gu. Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea[J]. Chinese Chemical Letters, ;2024, 35(5): 109089. doi: 10.1016/j.cclet.2023.109089 shu

Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea

Shuying Li ^{a, 1} ,
Weiwei ZhuGe ^{a, 1} ,
Xuan Sun ^{a, 1} ,
Chongzhen Sun ^a ,
Zhaojun Liu ^a ,
Chenghe Xiong ^a ,
Min Xiao ^{a, b} ,
Guofeng Gu ^{a, b, *,}

a.
National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao 266237, China
b.
NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, Shandong University, Qingdao 266237, China

guofenggu@sdu.edu.edu

Received Date: 7 July 2023
Revised Date: 7 September 2023
Accepted Date: 11 September 2023
Available Online: 17 September 2023

Figures(6)

The galactomannan from Antrodia cinnamomea (AC) is characterized as one of the important bioactive components that exhibits potential immunostimulatory propriety. The biological function of its corresponding oligosaccharide fragments has not been revealed yet. In this study, we reported the first chemical synthesis of the series of oligosaccharide fragments related to AC galactomannan via the convergent glycosylation strategy. The preliminary immunological evaluation of these synthesized AC oligosaccharides disclosed that the backbone tetrasaccharide 1d showed the best immunomodulatory ability on enhancing proliferation, phagocytosis and cytokines secretion of Raw264.7 macrophages in vitro, indicating its immense potential as an immunostimulant candidate.
- Antrodia cinnamomea,
- Galactomannan,
- Oligosaccharide,
- Immunostimulatory propriety,
- Chemical synthesis
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