Citation: Zihan Liu, Han Liu, Jialing Cheng, Hongliang Wang, Yanfang Yang, Jun Ye, Yuling Liu. Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives[J]. Chinese Chemical Letters, ;2024, 35(2): 109074. doi: 10.1016/j.cclet.2023.109074 shu

Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives

Zihan Liu ^{a, b} ,
Han Liu ^{a, b} ,
Jialing Cheng ^{a, b} ,
Hongliang Wang ^{a, b} ,
Yanfang Yang ^{a, b} ,
Jun Ye ^{a, b, *,} ,
Yuling Liu ^{a, b, *,}

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
b.
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

yelinghao@imm.ac.cn

ylliu@imm.ac.cn

Received Date: 11 July 2023
Revised Date: 3 September 2023
Accepted Date: 7 September 2023
Available Online: 9 September 2023

Figures(10)

Ulcerative colitis (UC) is a common progressive inflammatory disease whose incidence has increased rapidly in recent years, and can develop into colorectal cancer in severe cases. There are currently no adequate or effective treatments for UC due to the fact that some patients have found suboptimal results after repeated administration, while others have experienced adverse effects. With the rapid development of nanotechnology, developing innovative colon-targeting platforms is essential to improving efficacy, reducing side effects, and improving patient compliance. In this review, we summarize the pathophysiological characteristics of UC and the most recent status of numerous nanodrug delivery systems based on different targeting mechanisms in treating UC. Oral, intravenous, and rectal drug delivery nanoparticles targeting the colon are discussed, which can provide ideas for the design of colon-targeting nanoparticles for the treatment of colon diseases, especially for the treatment of UC. Last but not least, we provide a glimpse into the future of colon-targeted delivery systems, as well as future advancements in the field.
- Ulcerative colitis,
- Physiological characteristics,
- Colon-specific drug delivery,
- Mechanisms of action,
- Targeted therapy of UC
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