Citation: Yuanyi Zhou, Ke Ma, Jinfeng Liu, Zirun Zheng, Bo Hu, Yu Meng, Zhizhong Li, Mingshan Zhu. Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works[J]. Chinese Chemical Letters, ;2024, 35(6): 109056. doi: 10.1016/j.cclet.2023.109056 shu

Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works

Yuanyi Zhou ^{a, b, c, 1} ,
Ke Ma ^{d, 1} ,
Jinfeng Liu ^d ,
Zirun Zheng ^d ,
Bo Hu ^{a, b, d} ,
Yu Meng ^{a, b, d, *,} ,
Zhizhong Li ^{a, b, *,} ,
Mingshan Zhu ^{a, c, *,}

a.
Postdoctoral Innovation Practice Base, The First and Fifth Affiliated Hospital of Jinan University, Guangzhou 510632, China
b.
Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People’s Hospital), Heyuan 517465, China
c.
School of Environment, Jinan University, Guangzhou 511443, China
d.
Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China

mengy@jnu.edu.cn

tzzli@jnu.edu.cn

zhumingshan@jnu.edu.cn

Received Date: 29 June 2023
Revised Date: 31 August 2023
Accepted Date: 4 September 2023
Available Online: 10 September 2023

Figures(4)

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species (ROS) modulation would boost the prosperity of nanomedicine in cancer treatment. Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma (RCC) progression. Herein, Fe single atom-decorated graphene oxide (Fe₁-GO) nanosheet is developed to be a feasible autophagy inducer in RCC treatment. With the well-dispersed O−Fe₁−O active sites, Fe₁-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones. In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation. The in vivo therapeutic effect of Fe₁-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model, realizing an 89% reduction of tumor weight and good biosafety. This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.
- Fe single atom,
- Autophagy,
- Renal cell carcinoma,
- Graphene oxide,
- Cancer therapy
1. [1]
  B.I. Rini, S.C. Campbell, B. Escudier, Lancet 373 (2009) 1119–1132. doi: 10.1016/S0140-6736(09)60229-4
2. [2]
  J.J. Hsieh, M.P. Purdue, S. Signoretti, et al., Nat. Rev. Dis. Primers 3 (2017) 17009. doi: 10.1038/nrdp.2017.9
3. [3]
  J.M. Randall, F. Millard, R. Kurzrock, Cancer Metast. Rev. 33 (2014) 1109–1124. doi: 10.1007/s10555-014-9533-1
4. [4]
  J.S. Lam, O. Shvarts, J.T. Leppert, R.A. Figlin, A.S. Belldegrun, J. Urology 173 (2005) 1853–1862. doi: 10.1097/01.ju.0000165693.68449.c3
5. [5]
  Y. Fan, S. Liu, Y. Yi, H. Rong, J. Zhang, ACS Nano 15 (2021) 2005–2037. doi: 10.1021/acsnano.0c06962
6. [6]
  H. Xiang, W. Feng, Y. Chen, Adv. Mater. 32 (2020) 1905994. doi: 10.1002/adma.201905994
7. [7]
  X. Lu, S. Gao, H. Lin, J. Shi, Small 17 (2021) 2004467. doi: 10.1002/smll.202004467
8. [8]
  C. Zhai, Y. Chen, X. Huang, A.B. Isaev, M. Zhu, Environ. Funct. Mater. 1 (2022) 219–229.
9. [9]
  M. Huo, L. Wang, Y. Wang, Y. Chen, J. Shi, ACS Nano 13 (2019) 2643–2653.
10. [10]
  L. Wang, X. Qu, Y. Zhao, et al., ACS Appl. Mater. Interfaces 11 (2019) 35228–35237. doi: 10.1021/acsami.9b11238
11. [11]
  S. Liu, F. Xie, H. Wang, et al., Oncol. Rep. 33 (2015) 1372–1380. doi: 10.3892/or.2014.3693
12. [12]
  F. Li, Z. Ma, Z. Guan, et al., Int. J. Mol. Sci. 16 (2015) 8415–8429. doi: 10.3390/ijms16048415
13. [13]
  Q. Liu, Q. Fang, S. Ji, et al., Mol. Med. Rep. 17 (2018) 502–508.
14. [14]
  Â. de Fátima, W.F. Zambuzzi, L.V. Modolo, et al., Chem. Biol. Interact. 176 (2008) 143–150. doi: 10.1016/j.cbi.2008.08.003
15. [15]
  F. Deng, Y.X. Ma, L. Liang, P. Zhang, J. Feng, Biomed. Pharmacother. 97 (2018) 1269–1274. doi: 10.1016/j.biopha.2017.11.064
16. [16]
  A. Grimaldi, D. Santini, S. Zappavigna, et al., Cancer Biol. Ther. 16 (2015) 567–579. doi: 10.1080/15384047.2015.1018494
17. [17]
  Q. Zhang, S. Si, S. Schoen, et al., J. Exp. Clin. Cancer Res. 32 (2013) 99. doi: 10.1186/1756-9966-32-99
18. [18]
  J. Wu, R. Yang, L. Zhang, Z. Fan, S. Liu, Toxicol. Mech. Method 25 (2015) 312–319. doi: 10.3109/15376516.2015.1031415
19. [19]
  Y.J. Choi, E. Kim, J.W. Han, J.H. Kim, S. Gurunathan, Molecules 21 (2016) 375. doi: 10.3390/molecules21030375
20. [20]
  G.Y. Chen, C.L. Chen, H.Y. Tuan, et al., Adv. Healthc. Mater. 3 (2014) 1486–1495. doi: 10.1002/adhm.201300591
21. [21]
  G.Y. Chen, C.L. Meng, K.C. Lin, et al., Biomaterials 40 (2015) 12–22. doi: 10.1016/j.biomaterials.2014.11.034
22. [22]
  Z. Tang, L. Zhao, Z. Yang, et al., Int. J. Nanomed. 13 (2018) 2907–2919. doi: 10.2147/IJN.S159388
23. [23]
  R. Al-Gaashani, A. Najjar, Y. Zakaria, S. Mansour, M. Atieh, Ceram. Int. 45 (2019) 14439–14448. doi: 10.1016/j.ceramint.2019.04.165
24. [24]
  Y. Qu, L. Wang, Z. Li, et al., Adv. Mater. 31 (2019) 1904496. doi: 10.1002/adma.201904496
25. [25]
  S. Ruan, J. Wan, Y. Fu, et al., Bioconjugate Chem. 25 (2014) 1061–1068. doi: 10.1021/bc5001627
26. [26]
  M. Georgieva, Z. Gospodinova, M. Keremidarska-Markova, et al., Pharmaceutics 13 (2021) 424. doi: 10.3390/pharmaceutics13030424
27. [27]
  P.J. Kelly, S.E. Weiss, D.J. Sher, et al., J. Clin. Oncol. 28 (2010) 433–435. doi: 10.1200/JCO.2009.26.8193
1. [1]
  Ying Chen , Li Li , Junyao Zhang , Tongrui Sun , Xuan Zhang , Shiqi Zhang , Jia Huang , Yidong Zou . Tailored ionically conductive graphene oxide-encased metal ions for ultrasensitive cadaverine sensor. Chinese Chemical Letters, 2024, 35(8): 109102-. doi: 10.1016/j.cclet.2023.109102
2. [2]
  Wenyi Mei , Lijuan Xie , Xiaodong Zhang , Cunjian Shi , Fengzhi Wang , Qiqi Fu , Zhenjiang Zhao , Honglin Li , Yufang Xu , Zhuo Chen . Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells. Chinese Chemical Letters, 2024, 35(5): 108825-. doi: 10.1016/j.cclet.2023.108825
3. [3]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
4. [4]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
5. [5]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
6. [6]
  Jia-Li Xie , Tian-Jin Xie , Yu-Jie Luo , Kai Mao , Cheng-Zhi Huang , Yuan-Fang Li , Shu-Jun Zhen . Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection. Chinese Chemical Letters, 2024, 35(6): 109137-. doi: 10.1016/j.cclet.2023.109137
7. [7]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
8. [8]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
9. [9]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
10. [10]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
11. [11]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
12. [12]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
13. [13]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
14. [14]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
15. [15]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
16. [16]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
17. [17]
  Muhammad Humayun , Mohamed Bououdina , Abbas Khan , Sajjad Ali , Chundong Wang . Designing single atom catalysts for exceptional electrochemical CO2 reduction. Chinese Journal of Structural Chemistry, 2024, 43(1): 100193-100193. doi: 10.1016/j.cjsc.2023.100193
18. [18]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
19. [19]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
20. [20]
  Chaozheng He , Pei Shi , Donglin Pang , Zhanying Zhang , Long Lin , Yingchun Ding . First-principles study of the relationship between the formation of single atom catalysts and lattice thermal conductivity. Chinese Chemical Letters, 2024, 35(6): 109116-. doi: 10.1016/j.cclet.2023.109116

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(149)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142