Citation: Boran Cheng, Lei Cao, Chen Li, Fang-Yi Huo, Qian-Fang Meng, Ganglin Tong, Xuan Wu, Lin-Lin Bu, Lang Rao, Shubin Wang. Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging[J]. Chinese Chemical Letters, ;2024, 35(6): 108969. doi: 10.1016/j.cclet.2023.108969 shu

Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

Boran Cheng ^{a, 1} ,
Lei Cao ^{b, c, 1} ,
Chen Li ^{a, 1} ,
Fang-Yi Huo ^c ,
Qian-Fang Meng ^b ,
Ganglin Tong ^a ,
Xuan Wu ^a ,
Lin-Lin Bu ^{c, *,} ,
Lang Rao ^{b, *,} ,
Shubin Wang ^{a, *,}

a.
Department of Oncology, Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Cancer Institute, Peking University Shenzhen Hospital, Shenzhen-Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China
b.
Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, China
c.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China

lin-lin.bu@whu.edu.cn

lrao@szbl.ac.cn

shubinwang2013@163.com

Received Date: 17 June 2023
Revised Date: 20 August 2023
Accepted Date: 24 August 2023
Available Online: 27 August 2023

Figures(5)

As a type of new carbon-based nanomaterials, carbon dots (CDs) possess exceptional optical properties, making them highly desirable for use in fluorescent sensors. However, the CDs with deep-red (DR) or near-infrared (NIR) emission have rarely been reported. In this work, we prepared deep-red emissive fluorine-doped carbon quantum dots (F-CDs) by introducing a precursor simultaneously containing fluorine and amidogen. The synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00% ± 0.68%. Moreover, we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite (ClO⁻), with a limit of detection (LOD) as low as 15.4 nmol/L, indicating the high sensitivity of F-CDs to ClO⁻. In real samples, the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO⁻, with an error below 2%, suggesting their great potential in daily life. In cancer cell imaging, the F-CDs not only demonstrated high sensitivity to ClO⁻ but also exhibited excellent mitochondria targeting, as evidenced by the high Pearson's correlation coefficient (PCC) of 0.93 in colocalization analysis. The work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.
- Carbon dots,
- Near-infrared,
- Cell imaging,
- Mitochondria labeling,
- Hypochlorite determination
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