Citation: Qiang Li, Jiangbo Fan, Hongkai Mu, Lin Chen, Yongzhen Yang, Shiping Yu. Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy[J]. Chinese Chemical Letters, ;2024, 35(6): 108947. doi: 10.1016/j.cclet.2023.108947 shu

Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

Qiang Li ^{a, b, 1} ,
Jiangbo Fan ^{b, 1} ,
Hongkai Mu ^b ,
Lin Chen ^{c, d} ,
Yongzhen Yang ^{c, d, *,} ,
Shiping Yu ^{b, *,}

a.
The Second Hospital of Shanxi Medical University, Taiyuan 030001, China
b.
Shanxi Medical University, Taiyuan 030001, China
c.
Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China
d.
Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, China

yyztyut@126.com

yushiping6@126.com

Received Date: 5 July 2023
Revised Date: 16 August 2023
Accepted Date: 17 August 2023
Available Online: 19 August 2023

Figures(4)

Carbon dots (CDs) with precise targeting function show great potential in the field of drug delivery therapeutics. In this study, the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence (NLS) were loaded with adriamycin (DOX) to obtain a nucleus-targeting orange-emissive CDs drug delivery system (CDs-NLS-DOX), which delivered DOX to tumor cell nuclei to enhance its anti-tumor activity. The drug carrier orange-emissive CDs showed excitation-independent behavior, stable and enhanced imaging capability and good biocompatibility in vitro and in vivo. Meanwhile, the CDs-NLS could target the nuclei efficiently, and the CDs-NLS-DOX complexes had a high drug loading rate (59.4%) after loading DOX, exhibiting pH-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic environment. In addition, the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells (HepG2). The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free DOX. In short, CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery system for tumor treatment.
- Carbon dots,
- Nucleus-targeting,
- Adriamycin,
- Drug delivery system,
- Liver cancer therapy
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沈阳化工大学材料科学与工程学院沈阳 110142