Citation: Ji Zhang, Tong Zhang, Qiao An, Peng Zhang, Cai-Yan Tian, Chun-Mao Yuan, Ping Yi, Zhan-Xing Hu, Xiao-Jiang Hao. Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora[J]. Chinese Chemical Letters, ;2024, 35(6): 108927. doi: 10.1016/j.cclet.2023.108927 shu

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

Ji Zhang ^{a, b, c, 1} ,
Tong Zhang ^{a, b, c, 1} ,
Qiao An ^{a, b} ,
Peng Zhang ^{a, b} ,
Cai-Yan Tian ^{a, b, d} ,
Chun-Mao Yuan ^{a, b} ,
Ping Yi ^{a, b} ,
Zhan-Xing Hu ^{a, b, *,} ,
Xiao-Jiang Hao ^{a, b, e, f, *,}

a.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
b.
Natural Products Research Center of Guizhou Province, Guiyang 550014, China
c.
School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China
d.
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
e.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, China
f.
Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Kunming 650201, China

huzhxi88@163.com

haoxj@mail.kib.ac.cn

Received Date: 24 June 2023
Revised Date: 8 August 2023
Accepted Date: 10 August 2023
Available Online: 12 August 2023

Figures(5)

Three novel matrine-type alkaloids (1–3) and two unprecedented aloperine-type alkaloids (4 and 5) were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively. Notably, compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton, while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system respectively. Moreover, compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core, and compound 5 characterized by rare 6/6/6/6 tetracyclic skeleton. Their structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Biological tests indicated that compound 5 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin.
- Matrine-type alkaloids,
- Aloperine-type alkaloids,
- Sophora tonkinensis,
- Sophora alopecuroides,
- Anti-tobacco mosaic virus
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