Citation: Xing Tian, Di Wu, Wanheng Wei, Guifu Dai, Zhanxian Li, Benhua Wang, Mingming Yu. A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue[J]. Chinese Chemical Letters, ;2024, 35(6): 108912. doi: 10.1016/j.cclet.2023.108912 shu

A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue

Xing Tian ^{a, 1} ,
Di Wu ^{b, 1} ,
Wanheng Wei ^a ,
Guifu Dai ^{b, *,} ,
Zhanxian Li ^a ,
Benhua Wang ^{c, *,} ,
Mingming Yu ^{a, *,}

a.
Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
b.
School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China
c.
Shenzhen Research Institute of Central South University, Shenzhen 518057, China

daiguifu@zzu.edu.cn

benhuawang@csu.edu.cn

yumm@zzu.edu.cn

Received Date: 2 June 2023
Revised Date: 7 August 2023
Accepted Date: 8 August 2023
Available Online: 9 August 2023

Figures(5)

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases. Polarity, a key parameter of the microenvironment, is closely associated with many diseases and dysfunctions in the body. It is important to elucidate the relationship between the physiological activity of lipid droplets (LDs) and the polarity of the microenvironment. In this work, based on push-pull mechanism, a fluorescent probe (E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (PPTH) with aggregation-induced emission (AIE) properties for the detection of polarity changes in cells was synthesized. PPTH not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.
- Lipid droplets,
- AIE,
- Polarity,
- Ferroptosis,
- Fatty liver
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