Citation: Tao Yu, Vadim A. Soloshonok, Zhekai Xiao, Hong Liu, Jiang Wang. Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline[J]. Chinese Chemical Letters, ;2024, 35(4): 108901. doi: 10.1016/j.cclet.2023.108901 shu

Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline

Tao Yu ^{a, b} ,
Vadim A. Soloshonok ^{c, d} ,
Zhekai Xiao ^e ,
Hong Liu ^{a, b, e, *,} ,
Jiang Wang ^{a, e, f, *,}

a.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China
c.
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, San Sebastian 20018, Spain
d.
IKERBASQUE, Basque Foundation for Science, Bilbao 48013, Spain
e.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China
f.
Lingang Laboratory, Shanghai 200031, China

hliu@simm.ac.cn

jwang@lglab.ac.cn

Received Date: 3 July 2023
Revised Date: 4 August 2023
Accepted Date: 6 August 2023
Available Online: 9 August 2023

Figures(9)

Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties, which enable them to exhibit diverse biological activities such as anti-bacterial, anti-oxidant, anti-inflammatory, and anti-tumor properties. Furthermore, Schiff base metal complexes can serve as reagents and catalysts in chemical reactions. This review aims to provide an overview of our recently published studies on Cu(Ⅱ) and Pd(Ⅱ) complexes derived from proline Schiff base ligands. We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral resolution.
- Schiff bases,
- Biological activity,
- Tailor-made amino acids,
- Asymmetric synthesis,
- Chiral tridentate ligands,
- Square-planar Cu(Ⅱ)-complexes,
- Square-planar Pd(Ⅱ)-complexes
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沈阳化工大学材料科学与工程学院沈阳 110142