Citation: Tong Li, Leping Pan, Yan Zhang, Jihu Su, Kai Li, Kuiliang Li, Hu Chen, Qi Sun, Zhiyong Wang. Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp³)-H functionalization[J]. Chinese Chemical Letters, ;2024, 35(4): 108897. doi: 10.1016/j.cclet.2023.108897 shu

Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp³)-H functionalization

Tong Li ^{a, 1} ,
Leping Pan ^{b, 1} ,
Yan Zhang ^a ,
Jihu Su ^c ,
Kai Li ^a ,
Kuiliang Li ^a ,
Hu Chen ^a ,
Qi Sun ^{a, *,} ,
Zhiyong Wang ^{a, *,}

a.
Hefei National Center for Physical Sciences at Microscale, Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China
b.
Anhui University of Science and Technology, Huainan 232001, China
c.
CAS Key Laboratory of Microscale Magnetic Resonance, Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China

sunqi924@ustc.edu.cn

zwang3@ustc.edu.cn

Received Date: 11 June 2023
Revised Date: 2 August 2023
Accepted Date: 3 August 2023
Available Online: 5 August 2023

Figures(11)

An efficient NH and C(sp³)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.
- Electrochemical,
- Metal-free,
- Oxazole,
- Oxidant-free
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沈阳化工大学材料科学与工程学院沈阳 110142

Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp3)-H functionalization

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通讯作者: 陈斌, bchen63@163.com

Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp³)-H functionalization