Citation: Kun-Heng Li, Hong-Yang Zhao, Dan-Dan Wang, Ming-Hui Qi, Zi-Jian Xu, Jia-Mi Li, Zhi-Li Zhang, Shi-Wen Huang. Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death[J]. Chinese Chemical Letters, ;2024, 35(5): 108882. doi: 10.1016/j.cclet.2023.108882 shu

Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China

swhuang@whu.edu.cn

Received Date: 29 May 2023
Revised Date: 27 July 2023
Accepted Date: 2 August 2023
Available Online: 9 August 2023

Figures(4)

AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death (ICD) inducers. To date, several mitochondria or endoplasmic reticulum (ER)-targeted aggregation-induced emission (AIE) molecules have been developed and have evoked massive ICD in cells. However, due to the complex physicochemical environment in cells, these small AIE molecules cannot maintain a stable aggregate state, which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species (ROS), and thus reducing the effect of the photosensitizer to elicit ICD. AIEgen-based nanomicelles, which maintain a stable micellar structure, can prevent defects of AIE molecules in photodynamic therapy (PDT) applications. Therefore, in this study, a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.
- Aggregation induced emission,
- Photodynamic therapy,
- Immunogenic cell death,
- Reactive oxygen species,
- Nanophotosensitizer,
- Mitochondria
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