Citation: Selvaraj Muthusamy, Kanagaraj Rajalakshmi, Palanisamy Kannan, Yun-Sik Nam, Dongwei Zhu, Yeonggil Seo, Jong-Won Song, Dong Nyoung Heo, Il Keun Kwon, Yuanguo Xu. Quantitative detection of citrate for early stage diagnosing of prostate cancer: Discriminating normal to cancer in prostate tissues[J]. Chinese Chemical Letters, ;2024, 35(2): 108880. doi: 10.1016/j.cclet.2023.108880 shu

Quantitative detection of citrate for early stage diagnosing of prostate cancer: Discriminating normal to cancer in prostate tissues

a.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
b.
College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
c.
Advanced Analysis Center, Korea Institute of Science & Technology, Seongbuk-gu, Seoul 02792, Republic of Korea
d.
School of Medicine, Jiangsu University, Zhenjiang 212013, China
e.
Department of Chemistry Education, Daegu University, Gyeongsan-si, Gyeongsangbuk-do 38453, Republic of Korea
f.
Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea

rajselva311@ujs.edu.cn

ktpkannan@zjxu.edu.cn

xuyg@ujs.edu.cn

Received Date: 31 January 2023
Revised Date: 19 July 2023
Accepted Date: 1 August 2023
Available Online: 5 August 2023

Figures(8)

Prostate cancer (PC) biomarker-citrate detection is clinically important to diagnose PC in early stages. Methylquinolinium iodide (Q) conjugated indole-phenylboronic acid (IB) was designed as a red-emissive QIB probe for the detection of citrate through Lewis acid–base reaction and intramolecular charge transfer (ICT) sensing mechanisms. Boronic acid acts as Lewis acid as well as citrate (Lewis base) recognition unit. The probe reacted with citrate, showing enhanced red emissions. Since the probe has excellent water solubility and great biocompatibility, practical application in biological systems is possible. Citrate was monitored precisely in the mitochondria organelle (in vitro) of living cells with a positive charge on QIB. Also, endogenous (in situ) citrate was detected quantitatively to discriminate non-cancerous and PC mice, observed strong and lower (negligible) emission intensity on non-cancerous and cancerous prostate tissues, respectively. Because, the concentration of citrate is higher in healthy prostate compared with PC prostate. Furthermore, the analysis of sliced prostate tissues can give PC-related information for clinical diagnosis to prevent and treat PC in the initial stages. Therefore, we believe that the present probe is a promising biochemical reagent in diagnosing PC.
- Prostate cancer,
- Biomarker-citrate,
- Boronic acid,
- Lewis acid/base-ICT,
- Red-emissive,
- Mitochondria targeting,
- Prostate tissue
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1.
沈阳化工大学材料科学与工程学院沈阳 110142