Citation: Maolin Sun, Chaoming Liang, Liming Cao, Yaguo Wang, Jiasheng Yang, Shiyu Hou, Wei Yu, Yueyue Ma, Ruihua Cheng, Jinxing Ye. Two-step continuous flow process of sodium tanshinone IIA sulfonate using a 3D circular cyclone-type microreactor[J]. Chinese Chemical Letters, ;2024, 35(1): 108738. doi: 10.1016/j.cclet.2023.108738 shu

Two-step continuous flow process of sodium tanshinone IIA sulfonate using a 3D circular cyclone-type microreactor

Maolin Sun ^{a, b, 1} ,
Chaoming Liang ^{a, 1} ,
Liming Cao ^b ,
Yaguo Wang ^a ,
Jiasheng Yang ^b ,
Shiyu Hou ^c ,
Wei Yu ^{b, d} ,
Yueyue Ma ^a ,
Ruihua Cheng ^{a, *,} ,
Jinxing Ye ^{a, b, *,}

a.
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China
b.
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
c.
School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
d.
Shanghai No.1 Biochemical & Pharmaceutical Co., Ltd., Shanghai 200080, China

rhcheng@gdut.edu.cn

yejx@ecust.edu.cn

jinxingye@gdut.edu.cn

Received Date: 12 May 2023
Revised Date: 15 June 2023
Accepted Date: 25 June 2023
Available Online: 28 June 2023

Figures(7)

A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate (STS). Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production. We constructed a telescoped two-step continuous flow platform. This involved a continuous tanshinone IIA sulfonation and in-line salt formation. For the setup, we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining. Compared to the 68% yield for 2 h in batch, the two-step continuous flow had an STS yield of 90%, achieved for a total residence time of < 3.0 min under optimal conditions. The proposed continuous flow method vastly simplified the operation and improved procedural safety, while significantly reducing the required acid content and wastewater production.
- Continuous flow,
- Sodium tanshinone IIA sulfonate,
- Cardiovascular,
- Microreactor,
- Green chemistry
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沈阳化工大学材料科学与工程学院沈阳 110142