Citation: Ling-Ling Wu, Xiangchuan Meng, Qingyang Zhang, Xiaowan Han, Feiya Yang, Qinghua Wang, Hai-Yu Hu, Nianzeng Xing. Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy[J]. Chinese Chemical Letters, ;2024, 35(4): 108663. doi: 10.1016/j.cclet.2023.108663 shu

Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

Ling-Ling Wu ^{a, b, 1} ,
Xiangchuan Meng ^{b, 1} ,
Qingyang Zhang ^b ,
Xiaowan Han ^b ,
Feiya Yang ^a ,
Qinghua Wang ^{b, *,} ,
Hai-Yu Hu ^{b, *,} ,
Nianzeng Xing ^{a, *,}

a.
Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
b.
State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China

wangqinghua@imm.ac.cn

haiyu.hu@imm.ac.cn

xingnianzeng@126.com

Received Date: 10 May 2023
Revised Date: 5 June 2023
Accepted Date: 7 June 2023
Available Online: 11 June 2023

Figures(4)

Photoacoustic agents combining photodynamic therapy (PDT) and photothermal therapy (PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared (NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging (PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol, -thio, and -seleno moieties into NIR heptamethine cyanine (Cy7) skeleton (Cy7-X-NH₂, X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for PDT. Additionally, we designed a series of nitroreductase (NTR)-activated photoacoustic probes (Cy7-X-NO₂, X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe, Cy7-Se-NO₂-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.
- Heavy-atom effect,
- Phototherapy,
- Photoacoustic imaging,
- Hypoxia-responsive,
- Prostate cancer
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沈阳化工大学材料科学与工程学院沈阳 110142