Citation: Lulu Zheng, Bo Hu, Deyao Zhao, Wenjing Liu, Qing Liu, Yuanyu Huang, Shaobo Ruan. Recent progresses of exosome–liposome fusions in drug delivery[J]. Chinese Chemical Letters, ;2024, 35(2): 108647. doi: 10.1016/j.cclet.2023.108647 shu

Recent progresses of exosome–liposome fusions in drug delivery

Lulu Zheng ^{a, 1} ,
Bo Hu ^{a, 1} ,
Deyao Zhao ^b ,
Wenjing Liu ^{a, c} ,
Qing Liu ^a ,
Yuanyu Huang ^{a, *,} ,
Shaobo Ruan ^{a, *,}

a.
School of Life Science, Advanced Research Institute of Multidisciplinary Science, School of Medical Technology, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China
b.
Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
c.
Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing 101149, China

yyhuang@bit.edu.cn

ruanshaobo@bit.edu.cn

Received Date: 21 March 2023
Revised Date: 25 May 2023
Accepted Date: 2 June 2023
Available Online: 4 June 2023

Figures(7)

Exosomes are membrane-bound nanoscale extracellular vesicles, which produced by almost all organisms. Due to the excellent biocompatibility, long circulation time as well as low immunogenicity, exosomes as naturally-derived drug delivery carriers have experienced explosive growth over the past decades. However, issues such as insufficient loading efficiency, heterogeneous delivery efficiency, uncontrollable targeting ability, and low production limit their wide application. Recently, the emerging exosome–liposome fusion strategy has become a potential approach to solve such issues. Thus, this review mainly focuses on the currently developed exosome–liposome fusion strategy and their application in drug delivery as well as disease treatment. This review aims to shed light on the advantages of fusion strategy in drug delivery and provides a better understanding for more rational design. The current challenge and future perspective regarding their clinical translation and application will also be discussed.
- Exosome,
- Liposome,
- Membrane fusion,
- Drug delivery,
- Disease treatment
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