Citation: Jiang-Hai Ye, Guo-Yong Luo, Chen-Liang Zhao, Zheng-Ming Liang, Jin-Huai Wei, Ya-Hua Liu, Kang He, Lu-Tai Pan, Jing-Jie Zhang, Juan Zou, Hong-Jie Zhang. Flavidanolides A and B from Isodon flavidus[J]. Chinese Chemical Letters, ;2023, 34(9): 108621. doi: 10.1016/j.cclet.2023.108621 shu

Flavidanolides A and B from Isodon flavidus

Jiang-Hai Ye ^{a, 1} ,
Guo-Yong Luo ^{a, 1} ,
Chen-Liang Zhao ^{a, b, 1} ,
Zheng-Ming Liang ^{b, 1} ,
Jin-Huai Wei ^a ,
Ya-Hua Liu ^a ,
Kang He ^a ,
Lu-Tai Pan ^a ,
Jing-Jie Zhang ^a ,
Juan Zou ^{a, *,} ,
Hong-Jie Zhang ^{b, *,}

a.
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
b.
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, China

zoujuan466@gzy.edu.cn

zhanghj@hkbu.edu.hk

Received Date: 21 March 2023
Revised Date: 23 May 2023
Accepted Date: 28 May 2023
Available Online: 30 May 2023

Figures(4)

A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A (1), a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton, together with flavidanolide B (2), an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric units. Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses. Their plausible biosynthetic routes were also proposed. In the bioassay, flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium (PDTC), which provided evidence for the medicinal value of I. flavidus as a folk medicine for treating inflammatory diseases.
- Isodon flavidus,
- Rearranged six/seven/five-membered skeleton,
- Heterodimeric diterpenoid,
- Plausible biosynthetic pathway,
- Antiinflammatory effects
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