Citation: Tairong Kuang, Linbing Deng, Sitao Shen, Hongxia Deng, Zhisen Shen, Zhenjie Liu, Zhengping Zhao, Feng Chen, Mingqiang Zhong. Nano-silver-modified polyphosphazene nanoparticles with different morphologies: Design, synthesis, and evaluation of antibacterial activity[J]. Chinese Chemical Letters, ;2023, 34(12): 108584. doi: 10.1016/j.cclet.2023.108584 shu

Nano-silver-modified polyphosphazene nanoparticles with different morphologies: Design, synthesis, and evaluation of antibacterial activity

a.
Zhejiang Key Laboratory of Plastic Modification and Processing Technology, College of Material Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
b.
Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated LiHuili Hospital, Ningbo University, Ningbo 315040, China
c.
Department of Vascular Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China

szs7216@163.com

lawson4001@zju.edu.cn

Received Date: 3 April 2023
Revised Date: 15 May 2023
Accepted Date: 16 May 2023
Available Online: 21 May 2023

Figures(4)

Drug-resistant bacteria present a severe threat to public health, emphasizing the importance of developing broad-spectrum antibacterial agents that are free from drug resistance. Among silver-based antibacterial agents, nano-silver has been found to exhibit the most promising and comprehensive performance. The exploration of the antibacterial capacity and morphological changes of silver nanoparticles (AgNPs) could offer a starting point for the development of safe and efficient antibacterial agents. In this study, three types of nano-silver-modified polyphosphazene (PRV) nanoparticles with different morphologies were synthesized using precipitation polymerization. These nanoparticles were characterized using various techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The antibacterial activity of these nanoparticles against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was assessed using minimum inhibitory concentration (MIC)/minimum bactericidal concentration (MBC) tests and inverted fluorescence microscopy. Our results revealed that the antibacterial activity of silver nanoparticles can vary significantly depending on their immobilized form. Ag@PRV Strawberry-like nanoparticles (NPs) exhibited higher antibacterial activity compared to Ag@PRV Yolk-Shell NPs and Ag@PRV Cable-like nanofibers (NFs). Notably, all three types of synthesized nanoparticles demonstrated a stronger bactericidal effect on Gram-positive bacteria than Gram-negative bacteria. Live/dead bacterial staining and scanning electron microscopy demonstrated that silver can kill bacteria by altering the permeability of their cell membranes. These findings offer valuable insights for designing and practically applying new silver-based antibacterial agents in the future.
- Nano-silver,
- Polyphosphazene,
- Morphology change,
- Antibacterial activity,
- Antibacterial mechanism
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1.
沈阳化工大学材料科学与工程学院沈阳 110142