Citation: Jiaquan Xu, Ting Li, Zhendong Yu, Lili Song, Xiu-Xiu Xu, Hui Li. Rapid analysis of metal ions and organic compounds in strong acidic solutions by nano-ESI mass spectrometry[J]. Chinese Chemical Letters, ;2024, 35(2): 108578. doi: 10.1016/j.cclet.2023.108578 shu

Rapid analysis of metal ions and organic compounds in strong acidic solutions by nano-ESI mass spectrometry

Jiaquan Xu ^a ,
Ting Li ^a ,
Zhendong Yu ^a ,
Lili Song ^a ,
Xiu-Xiu Xu ^{b, *,} ,
Hui Li ^{a, *,}

a.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China
b.
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

xiuxiu-xu@foxmail.com

huili_201860188@ecut.edu.cn

Received Date: 22 November 2022
Revised Date: 24 April 2023
Accepted Date: 14 May 2023
Available Online: 20 May 2023

Figures(6)

Rapid analysis of metal ions and organic compounds in strong acidic solutions is of sustainable interest in multiple disciplines. However, complicated and time-consuming pretreatments are always required for MS analysis of the compounds in strong acidic solutions. Otherwise, it will result in a weak signal and cause serious damage to the mass spectrometer. Herein, a simple method inherited from nano-ESI MS was developed for rapid analysis of strong acidic solutions. Nanoliter (nL) strong acidic solution was first loaded in the nano-ESI emitter, followed by evaporation to remove the H⁺ and leave the analytes on the wall of the nano-ESI emitter. The evaporation process can be completed within 1 min because of the extremely tiny volume (≤1 nL) of the loaded solution. Then, the dried analytes on the wall of the nano-ESI emitter were redissolved by loading a new solvent, followed by nano-ESI MS analysis. By using this method, metal ions and organic compounds in the strong acidic solution can be detected with low sample consumption (1 nL), high speed (< 2 min/sample), high sensitivity (limit of detection = 0.2 µg/L), and high accuracy (> 90%). Proof-of-concept applications of the present method have been successfully achieved for the analysis of gastric juice (pH of the sample = 1), monitoring reaction catalyzed by strong acid (pH of the system = 0), and micro-area analysis of ores (pH of the extraction solvent = 0), showing great application potential in multiple fields.
- Strong acidic solutions,
- Nano-ESI MS,
- Rapid analysis,
- Reaction monitoring,
- Micro-area analysis,
- Gastric juice analysis
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