Citation: Qingyu Huan, Tao Lin, Yong-Hong Fu, Jun-Li Hou. Vesicle fusion induced by zwitterionic amphiphilic channels[J]. Chinese Chemical Letters, ;2024, 35(1): 108566. doi: 10.1016/j.cclet.2023.108566 shu

Vesicle fusion induced by zwitterionic amphiphilic channels

Department of Chemistry, Fudan University, Shanghai 200433, China

^☆

houjl@fudan.edu.cn

Received Date: 10 February 2023
Revised Date: 7 May 2023
Accepted Date: 10 May 2023
Available Online: 12 May 2023

Figures(4)

A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones. The channels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface, which endows the channels with amphiphilicity. The zwitterionic amphiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.
- Vesicle fusion,
- Pillar[5]arene,
- Electrostatic interaction,
- Lipid bilayers
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