Citation: Heng Wei, Xia Li, Fengwei Huang, Shujuan Wu, Huimin Ding, Qianxue Chen, Mingchang Li, Xianjun Lang. Red light-driven generation of reactive oxygen species for the targeted oxidation of glioma cells and thiols over covalent organic framework[J]. Chinese Chemical Letters, ;2023, 34(12): 108564. doi: 10.1016/j.cclet.2023.108564 shu

Red light-driven generation of reactive oxygen species for the targeted oxidation of glioma cells and thiols over covalent organic framework

Renmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

mingcli@whu.edu.cn

xianjunlang@whu.edu.cn

Received Date: 8 January 2023
Revised Date: 8 May 2023
Accepted Date: 10 May 2023
Available Online: 12 May 2023

Figures(7)

Reactive oxygen species (ROS) are essential for biological processes like cell signaling and chemical processes like organic oxidation. Moreover, the sufficient generation of ROS plays a significant role in targeted tumor treatments or oxidation of organics. Herein, a hydrazone-linked porphyrin covalent organic framework (Por-DETH-COF) is developed for red light-induced generation of ROS like singlet oxygen (¹O₂) or superoxide (O₂^•−) to undertake different but targeted oxidations. First, ¹O₂ is adopted in photodynamic therapy (PDT) for the oxidation of glioma cells. The PDT efficiency of Por-DETH-COF on the apoptosis of glioma cells is explored through flow cytometry and western blot assay. The apoptosis rate of glioma cells significantly increases over Por-DETH-COF under 660 nm red light illumination, suggestive of the potency of ¹O₂. Second, O₂^•− is employed for the targeted oxidation of thiols. A series of thiols could be efficiently oxidized to corresponding disulfides over Por-DETH-COF under 660 nm red light illumination, indicative of the significance of O₂^•−. This work highlights the potential of covalent organic frameworks in generating ROS for precise medical applications of complex chemical environments.
- Reactive oxygen species,
- Covalent organic framework,
- Oxidation,
- Photodynamic therapy,
- Glioma cells
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