Citation: Yuhang He, Chao Tian, Guanghui An, Guangming Li. β-C(sp³)−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis[J]. Chinese Chemical Letters, ;2024, 35(2): 108546. doi: 10.1016/j.cclet.2023.108546 shu

β-C(sp³)−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China

chemagh@163.com

gmli@hlju.edu.cn

Received Date: 9 December 2022
Revised Date: 27 April 2023
Accepted Date: 7 May 2023
Available Online: 8 May 2023

Figures(7)

An atom economic β-C(sp³)−H chlorination of amide derivatives has been developed. This mild protocol employs CuCl₂ instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives. Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer (LMCT)/1,4-hydrogen atom transfer (HAT) cascade.
- Photoinduced copper catalysis,
- Ligand-to-metal charge transfer,
- 1,4-Hydrogen atom transfer,
- β-Halogenated amide,
- Late-stage functionalization
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沈阳化工大学材料科学与工程学院沈阳 110142

β-C(sp3)−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

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通讯作者: 陈斌, bchen63@163.com

β-C(sp³)−H chlorination of amide derivatives via photoinduced copper charge transfer catalysis