Citation: Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin. H₂S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection[J]. Chinese Chemical Letters, ;2024, 35(1): 108545. doi: 10.1016/j.cclet.2023.108545 shu

H₂S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection

Peng Shan ^{a, b, 1} ,
Jing Liao ^{a, b, 1} ,
Jiayi Li ^{a, 1} ,
Chengyan Wang ^{b, c} ,
Jie Zhou ^b ,
Linqiang Mei ^b ,
Yunlu Dai ^d ,
Qiang Wang ^{a, *,} ,
Wenyan Yin ^{b, *,}

a.
Laboratory for Micro-sized Functional Materials, Department of Chemistry and College of Elementary Education, Capital Normal University, Beijing 100048, China
b.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
c.
Department of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
d.
Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China

qwchem@gmail.com

yinwy@ihep.ac.cn

Received Date: 13 February 2023
Revised Date: 4 May 2023
Accepted Date: 7 May 2023
Available Online: 9 May 2023

Figures(6)

Radiation damage can cause a series of gastrointestinal (GI) tract diseases. The development of safe and effective GI tract radioprotectants still remains a great challenge clinically. Here, we firstly report an oral radioprotectant Gel@GYY that integrates a porous gelatin-based (Gel) hydrogel and a pH-responsive hydrogen sulfide (H₂S) donor GYY4137 (morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate). Gel@GYY has a remarkable adhesion ability and long retention time, which not only enables responsive release of low-dose H₂S in stomach and subsequently sustained release of H₂S in the whole intestinal tract especially in the colon, but also ensures a close contact between H₂S and GI tract. The released H₂S can effectively scavenge free radicals induced by X-ray radiation, reduce lipid peroxidation level, repair DNA damage and recover vital superoxide dismutase and glutathione peroxidase activities. Meanwhile, the released H₂S inhibits radiation-induced activation of nuclear factor κB (NF-κB), thus reducing inflammatory cytokines levels in GI tract. After treatment, Gel@GYY displays efficient excretion from mice body due to its biodegradability. This work provides a new insight for therapeutic application of intelligent H₂S-releasing oral delivery system and potential alternative to clinical GI physical damage protectant.
- Radiation,
- Gastrointestinal tract radioprotection,
- Hydrogen sulfide gas therapy,
- Gelatin-based hydrogel,
- Free radicals scavenging
1. [1]
  D. Zhang, D. Zhong, J. Ouyang, et al., Nat. Commun. 13 (2022) 1413. doi: 10.1080/0142159x.2022.2100251
2. [2]
  W. Fu, X. Zhang, L. Mei, et al., ACS Nano 14 (2020) 10001–10017. doi: 10.1021/acsnano.0c03094
3. [3]
  S.L. Warren, G.H. Whipple, J. Exp. Med. 35 (1922) 187–202. doi: 10.1084/jem.35.2.187
4. [4]
  M. Teo, D. Sebag-Montefiore, C.F. Donnellan, Clin. Oncol. 27 (2015) 656–667. doi: 10.1016/j.clon.2015.06.010
5. [5]
  J.M. Novak, J.T. Collins, M. Donowitz, et al., J. Clin. Gastroenterol. 1 (1979) 9–40. doi: 10.1097/00004836-197903000-00003
6. [6]
  M.I. Koukourakis, Anticancer Drugs 13 (2002) 181–209. doi: 10.1097/00001813-200203000-00001
7. [7]
  J. Xie, Y. Yong, X. Dong, et al., ACS Appl. Mater. Inter. 9 (2017) 14281–14291. doi: 10.1021/acsami.7b02622
8. [8]
  E. Seifter, J. Mendecki, S. Holtzman, et al., Pharmacol. Ther. 39 (1988) 357–365. doi: 10.1016/0163-7258(88)90083-6
9. [9]
  J. Du, Z. Gu, L. Yan, et al., Adv. Mater. 29 (2017) 1701268. doi: 10.1002/adma.201701268
10. [10]
  D. Zetner, L. Andersen, J. Rosenberg, Drug Res. 66 (2016) 281–296. doi: 10.1055/s-0035-1569358
11. [11]
  K.N. Mishra, B.A. Moftah, G.A. Alsbeih, Biomed. Pharmacother. 106 (2018) 610–617. doi: 10.1016/j.biopha.2018.06.150
12. [12]
  P. Haddad, B. Kalaghchi, F. Amouzegar-Hashemi, Radiother. Oncol. 77 (2005) 324–326. doi: 10.1016/j.radonc.2005.09.014
13. [13]
  R.Salvador E.Obrador, J.I. Villaescusa, et al., Biomedicines 8 (2020) 461. doi: 10.3390/biomedicines8110461
14. [14]
  C. Wang, J. Xie, X. Dong, et al., Small 16 (2020) 1906915. doi: 10.1002/smll.201906915
15. [15]
  S. Han, S. Lee, M. Cho, et al., Adv. Mater. 32 (2020) 2001566. doi: 10.1002/adma.202001566
16. [16]
  J. Colon, N. Hsieh, A. Ferguson, et al., Nanomedicine 6 (2010) 698–705. doi: 10.1016/j.nano.2010.01.010
17. [17]
  H. Liu, J. Wang, Y. Jing, et al., Part. Part. Syst. Charact. 34 (2017) 1700035. doi: 10.1002/ppsc.201700035
18. [18]
  X. Ren, M. Huo, M. Wang, et al., ACS Nano 13 (2019) 6438–6454. doi: 10.1021/acsnano.8b09327
19. [19]
  X. Zhang, J. Zhang, J. Wang, et al., ACS Nano 10 (2016) 4511–4519. doi: 10.1021/acsnano.6b00321
20. [20]
  J. Wang, X. Mu, Y. Li, et al., Small 14 (2018) 1703736. doi: 10.1002/smll.201703736
21. [21]
  S. Hua, Front. Pharmacol. 11 (2020) 524. doi: 10.3389/fphar.2020.00524
22. [22]
  C. Szabo, Nat. Rev. Drug Discov. 6 (2007) 917–935. doi: 10.1038/nrd2425
23. [23]
  V.S. Lin, W. Chen, X. Ming, et al., Chem. Soc. Rev. 44 (2015) 4596–4618. doi: 10.1039/C4CS00298A
24. [24]
  F. Rong, T. Wang, Q. Zhou, et al., Bioact. Mater. 19 (2023) 198–216.
25. [25]
  F. Ghanbari, M. Khaksari, G. Vaezi, et al., J. Mol. Neurosci. 67 (2019) 133–141. doi: 10.1007/s12031-018-1218-8
26. [26]
  W. Liang, J. Chen, L. Li, et al., ACS Appl. Mater. Inter. 11 (2019) 14619–14629. doi: 10.1021/acsami.9b01886
27. [27]
  V. Citi, E. Piragine, L. Tastai, et al., Curr. Med. Chem. 25 (2018) 4380–4401. doi: 10.2174/0929867325666180212120504
28. [28]
  H. Wei, X. Li, X. Tang, J. Clin. Neurosci. 21 (2014) 1665–1669. doi: 10.1016/j.jocn.2014.01.006
29. [29]
  Y.Lu X.Wu, B. Liu, et al., Chin. Chem. Lett. 32 (2021) 2380–2384. doi: 10.1016/j.cclet.2021.02.065
30. [30]
  L. An, X. Wang, X. Rui, et al., Angew. Chem. Int. Ed. 57 (2018) 15782–15786. doi: 10.1002/anie.201810082
31. [31]
  J. Li, L. Xie, W. Sang, et al., Angew. Chem. Int. Ed. 61 (2022) e202200830. doi: 10.1002/anie.202200830
32. [32]
  A. Sivarajah, M. Collino, M. Yasin, et al., Shock 31 (2009) 267–274. doi: 10.1097/SHK.0b013e318180ff89
33. [33]
  Y. Huang, H. Li, X. He, et al., Chin. Chem. Lett. 31 (2020) 787–791. doi: 10.1016/j.cclet.2019.05.025
34. [34]
  J.L. Greaney, J.L. Kutz, S.W. Shank, et al., Hypertension 69 (2017) 902–909. doi: 10.1161/HYPERTENSIONAHA.116.08964
35. [35]
  D.J. Polhemus, Z. Li, C.B. Pattillo, et al., Cardiovasc. Ther. 33 (2015) 216–226. doi: 10.1111/1755-5922.12128
36. [36]
  J.L. Wallace, P. Nagy, T.D. Feener, et al., Br. J. Pharmacol. 177 (2020) 769–777. doi: 10.1111/bph.14641
37. [37]
  L. Li, M. Whiteman, Y. Guan, et al., Circulation 117 (2008) 2351–2360. doi: 10.1161/CIRCULATIONAHA.107.753467
38. [38]
  Y.W. Won, Y.H. Kim, J. Control. Release 127 (2008) 154–161. doi: 10.1016/j.jconrel.2008.01.010
39. [39]
  J.R. Adams, S. Senapati, S.L. Haughney, et al., J. Biomed. Mater. Res. A 107 (2019) 1754–1762. doi: 10.1002/jbm.a.36691
40. [40]
  C. Tondera, S. Hauser, A. Krüger-Genge, et al., Theranostics 6 (2016) 2114–2128. doi: 10.7150/thno.16614
41. [41]
  L. Li, Y. Du, Z. Yin, et al., Colloids Surf. B 187 (2020) 110641. doi: 10.1016/j.colsurfb.2019.110641
42. [42]
  B. Naidu, A.T. Paulson, J. Appl. Polym. Sci. 121 (2011) 3495–3500. doi: 10.1002/app.34171
43. [43]
  S.K. Bhattacharyya, M. Dule, R. Paul, et al., ACS Biomater. Sci. Eng. 6 (2020) 5662–5674. doi: 10.1021/acsbiomaterials.0c00982
44. [44]
  S. Zhao, Y. Li, Q. Liu, et al., Adv. Funct. Mater. 30 (2020) 2004692. doi: 10.1002/adfm.202004692
45. [45]
  H. Staroszczyk, K. Sztuka, J. Wolska, et al., Acta A Mol. Biomol. Spectrosc. 117 (2014) 707–712. doi: 10.1016/j.saa.2013.09.044
46. [46]
  E.M. Krop, M.M. Hetherington, M. Holmes, et al., Food Hydrocoll 88 (2019) 101–113. doi: 10.1016/j.foodhyd.2018.09.040
47. [47]
  B. Yang, Y. Chen, J. Shi, Chem. Rev. 119 (2019) 4881–4985. doi: 10.1021/acs.chemrev.8b00626
48. [48]
  P.M. Kidd, Altern. Med. Rev. 2 (1997) 155–176.
49. [49]
  H. Rottenberg, J.B. Hoek, Aging Cell 16 (2017) 943–955. doi: 10.1111/acel.12650
50. [50]
  H. Gunaydin, M. Altman, J.M. Ellis, et al., ACS Med. Chem. Lett. 9 (2018) 528–533. doi: 10.1021/acsmedchemlett.8b00018
51. [51]
  N. Hekim, Z. Cetin, Z. Nikitaki, et al., Cancer Lett. 368 (2015) 156–163. doi: 10.1016/j.canlet.2015.04.016
52. [52]
  X. Zhao, L. Ning, X. Zhou, et al., Anal. Chem. 93 (2021) 4894–4901. doi: 10.1021/acs.analchem.0c05081
53. [53]
  Q. Zhang, H. Tao, Y. Lin, et al., Biomaterials 105 (2016) 206–221. doi: 10.2991/jrarc.2016.6.4.5
54. [54]
  M. Zu, D. Xie, B. Canup, et al., Biomaterials 279 (2021) 121178. doi: 10.1016/j.biomaterials.2021.121178
55. [55]
  R. Hajosch, M. Suckfuell, S. Oesser, et al., J. Biomed. Mater. Res. 94B (2010) 372–379. doi: 10.1002/jbm.b.31663
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H₂S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection