Citation: Min Dong, Rui Tang, Jing Li, Jiajia Zhao, Yu Wang, Lin Ouyang, Wei Lu, Jun Tao, Meng Dang, Yuxia Tang, Zhaogang Teng. Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy[J]. Chinese Chemical Letters, ;2024, 35(2): 108539. doi: 10.1016/j.cclet.2023.108539 shu

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

Min Dong ^{a, 1} ,
Rui Tang ^{a, 1} ,
Jing Li ^a ,
Jiajia Zhao ^a ,
Yu Wang ^a ,
Lin Ouyang ^{c, *,} ,
Wei Lu ^a ,
Jun Tao ^a ,
Meng Dang ^d ,
Yuxia Tang ^{b, *,} ,
Zhaogang Teng ^{a, *,}

a.
Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Post and Telecommunications, Nanjing 210023, China
b.
Laboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
c.
Department of Radiology, The 909th Hospital, Southeast Hospital, School of Medicine, Xiamen University, Zhangzhou 363000, China
d.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Institute of Functional Materials, Donghua University, Shanghai 201620, China

ddcqzg@126.com

tangyuxia5@163.com

iamzgteng@njupt.edu.cn

Received Date: 2 November 2022
Revised Date: 25 March 2023
Accepted Date: 5 May 2023
Available Online: 8 May 2023

Figures(4)

Photodynamic therapy (PDT) is an effective treatment method for tumors. But the specifically accumulated of photosensitizer was very difficult in the tumor site, which greatly limited the efficacy of PDT. Here, mitochondria-targeted Janus mesoporous nanoplatform (JPMO-Pt-CTPP-ZnPc) for PDT was prepared, the nanoplatform has uniform size (275 nm) and good dispersion and biocompatibility. The confocal laser scanning microscopy (CLSM) revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells, and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of JPMO-Pt-ZnPc. This revealed the modification of CTPP significantly improves the targeting ability of the nanoplatform. In vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser, and the survival rate of cells incubated with 60 µg/mL JPMO-Pt-CTPP-ZnPc was only 3%. Simultaneously, compared with JPMO-Pt-ZnPc (not modified with mitochondria targeting molecules CTPP), the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better, as it has targeted mitochondria in cells.
- Mesoporous materials,
- Janus particle,
- Photodynamic therapy,
- Mitochondria targeting,
- Tumor treatment
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沈阳化工大学材料科学与工程学院沈阳 110142