Citation: Bingchen Zhang, Ling Lin, Jizong Mao, Weisheng Mo, Zibo Li, Shengtao Wang, Yan Tang, Chunhui Cui, Yifen Wu, Zhiqiang Yu. Self-oxygenated co-assembled biomimetic nanoplatform for enhanced photodynamic therapy in hypoxic tumor[J]. Chinese Chemical Letters, ;2023, 34(10): 108518. doi: 10.1016/j.cclet.2023.108518 shu

Self-oxygenated co-assembled biomimetic nanoplatform for enhanced photodynamic therapy in hypoxic tumor

Bingchen Zhang ^{a, b, 1} ,
Ling Lin ^{a, 1} ,
Jizong Mao ^c ,
Weisheng Mo ^c ,
Zibo Li ^a ,
Shengtao Wang ^d ,
Yan Tang ^a ,
Chunhui Cui ^{c, *,} ,
Yifen Wu ^{b, *,} ,
Zhiqiang Yu ^{a, *,}

a.
Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523058, China
b.
Dongguan Institute of Clinical Cancer Research, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523058, China
c.
Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China
d.
Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China

drcuich@163.com

35662369@qq.com

yuzq@smu.edu.cn

Received Date: 9 February 2023
Revised Date: 23 April 2023
Accepted Date: 26 April 2023
Available Online: 4 May 2023

Figures(5)

Photodynamic therapy (PDT) has shown great application potential in cancer treatment and the important manifestation of PDT in the inhibition of tumors is the activation of immunogenic cell death (ICD) effects. However, the strategy is limited in the innate hypoxic tumor microenvironment. There are two key elements for the realization of enhanced PDT: specific cellular uptake and release of the photosensitizer in the tumor, and a sufficient amount of oxygen to ensure photodynamic efficiency. Herein, self-oxygenated biomimetic nanoparticles (CS@M NPs) co-assembled by photosensitizer prodrug (Ce6-S-S-LA) and squalene (SQ) were engineered. In the treatment of triple negative breast cancer (TNBC), the oxygen carried by SQ can be converted to reactive oxygen species (ROS). Meanwhile, glutathione (GSH) consumption during transformation from Ce6-S-S-LA to chlorin e6 (Ce6) avoided the depletion of ROS. The co-assembled (CS NPs) were encapsulated by homologous tumor cell membrane to improve the tumor targeting. The results showed that the ICD effect of CS@M NPs was confirmed by the significant release of calreticulin (CRT) and high mobility group protein B1 (HMGB1), and it significantly activated the immune system by inhibiting the hypoxia inducible factor-1alpha (HIF-1α)-CD39-CD73-adenosine a2a receptor (A2AR) pathway, which not only promoted the maturation of dendritic cells (DC) and the presentation of tumor specific antigens, but also induced effective immune infiltration of tumors. Overall, the integrated nanoplatform implements the concept of multiple advantages of tumor targeting, reactive drug release, and synergistic photodynamic therapy-immunotherapy, which can achieve nearly 90% tumor suppression rate in orthotopic TNBC models.
- Photodynamic therapy,
- Biomimetic nanoplatform,
- Self-oxygenated co-assembly nanoparticles,
- Immunogenic cell death,
- HIF-1α-CD39-CD73-A2AR pathway
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