Citation: Rui Wang, Jie Xu, Jin-Xiao Li, Bing-Bing Wu, Ruo-Xing Jin, Yu-Xiang Bi, Xi-Sheng Wang. Nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids toward the synthesis of α-alkyl-α-fluoro-alkylketones^☆[J]. Chinese Chemical Letters, ;2023, 34(10): 108490. doi: 10.1016/j.cclet.2023.108490 shu

Nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids toward the synthesis of α-alkyl-α-fluoro-alkylketones^☆

Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei 230026, China

^☆

xswang77@ustc.edu.cn

Received Date: 3 March 2023
Revised Date: 12 April 2023
Accepted Date: 20 April 2023
Available Online: 22 April 2023

Figures(3)

The synthesis methods of α-fluoro-arylketones were well-established through electrophilic/nucleophilic fluorination and transition metal catalyzed cross-coupling. However, due to the site selectivity and substrate restriction, only a few cases have been developed to afford α-alkyl-α-fluoro-alkylketones. Herein, we report a general and efficient method of preparing diverse α-alkyl-α-fluoro-alkylketones via nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with low-cost industrial raw material alkyl carboxylic acids. These transformations demonstrate high efficiency, mild conditions, and excellent functional group compatibility. This strategy provides a general and efficient method for the synthesis of α-alkyl-α-fluoro-alkylketones.
- Ni-catalyzed,
- Reductive coupling,
- α-Fluoroketones,
- α-Alkyl-α-fluoro-alkylketones,
- Monofluoroalkyl triflates
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids toward the synthesis of α-alkyl-α-fluoro-alkylketones☆

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通讯作者: 陈斌, bchen63@163.com

Nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids toward the synthesis of α-alkyl-α-fluoro-alkylketones^☆