Citation: Shihao Chen, Zhishang Zhang, Li Wei, Zhongxian Fan, Yue Li, Xuezhi Wang, Tongming Feng, Huaiyi Huang. Photo-catalytic Staphylococcus aureus inactivation and biofilm destruction with novel bis-tridentate iridium(Ⅲ) photocatalyst[J]. Chinese Chemical Letters, ;2023, 34(11): 108412. doi: 10.1016/j.cclet.2023.108412 shu

Photo-catalytic Staphylococcus aureus inactivation and biofilm destruction with novel bis-tridentate iridium(Ⅲ) photocatalyst

Shihao Chen ^{a, 1} ,
Zhishang Zhang ^{b, 1} ,
Li Wei ^b ,
Zhongxian Fan ^b ,
Yue Li ^c ,
Xuezhi Wang ^a ,
Tongming Feng ^{a, *,} ,
Huaiyi Huang ^{b, *,}

a.
The Fourth People’s Hospital of Foshan, Foshan 528000, China
b.
School of Pharmaceutical Science (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China
c.
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China

13702446638@139.com

huanghy87@mail.sysu.edu.cn

Received Date: 15 November 2022
Revised Date: 28 March 2023
Accepted Date: 30 March 2023
Available Online: 31 March 2023

Figures(4)

Bacterial infection is currently a serious challenge globally, causing death of thousands of human beings. New antimicrobial agents with novel mechanism of action are urgently needed. Transition metal complexes have shown great potentials in photodynamic and photocatalytic therapy. Herein, we take full advantage of metal photocatalyst and successfully developed a novel cyclometalated iridium(Ⅲ) complex (Ir1) with higher biofilm damage efficiency than the clinical antibiotics. Ir1 synergistically generates reactive oxygen species and coenzyme photocatalytic activity with high efficiency under white light irradiation. Combined with these properties, Ir1 exhibited excellent photoinactivation of S. aureus and effectively damaged the biofilm. This work provides a new approach for the development of antibacterial photodynamic therapy.
- Ir(Ⅲ) photocatalyst,
- NADH depletion,
- Reactive oxygen species,
- Antimicrobial photocatalytic therapy
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