Citation: Xiaoyu Shao, Shujing Xu, Xufeng Wan, Yang Zhou, Shuo Wang, Shuo Wu, Yuhuan Li, Xinyong Liu, Peng Zhan. Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018–2022 update)[J]. Chinese Chemical Letters, ;2023, 34(11): 108349. doi: 10.1016/j.cclet.2023.108349 shu

Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018–2022 update)

Xiaoyu Shao ^{a, 1} ,
Shujing Xu ^{a, 1} ,
Xufeng Wan ^a ,
Yang Zhou ^a ,
Shuo Wang ^a ,
Shuo Wu ^b ,
Yuhuan Li ^b ,
Xinyong Liu ^{a, *,} ,
Peng Zhan ^{a, *,}

a.
Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China
b.
CAMS Key Laboratory of Antiviral Drug Research,Beijing Key Laboratory of Antimicrobial Agents,NHC Key Laboratory of Biotechnology of Antibiotics,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

xinyongl@sdu.edu.cn

zhanpeng1982@sdu.edu.cn

Received Date: 8 January 2023
Revised Date: 15 March 2023
Accepted Date: 16 March 2023
Available Online: 20 March 2023

Figures(6)

Despite the improving coverage of preventative vaccines,hepatitis B remains a severe global public health problem,with more than 250 million patients living with hepatitis B virus (HBV) infection. Current available therapies,including nucleos(t)ide analogs and peginterferon,can control HBV replication but fail to eliminate covalently closed circular DNA (cccDNA) and achieve a cure. The HBV core protein (Cp) is a well-conserved structural protein,self-assembling to form the viral capsid. It involves in or modulates almost every stage of the HBV lifecycle,which makes it an attractive target for the development of new anti-HBV therapies. HBV core protein allosteric modulators (CpAMs) have become a hotspot in recent years. Herein,we provide a concise report focusing on the various medicinal chemistry strategies involved in the latest research (2018–2022) of HBV CpAMs,including high throughput screening (HTS),virtual screening (VS),drug repositioning,natural products,substitution decorating approach,scaffold hopping,molecular hybridization,prodrug strategy and conformational constraint strategy,to provide guidance for further development of new and effective anti-HBV drugs.
- HBV,
- Capsid,
- CpAMs,
- Medicinal chemistry strategies,
- Drug design
1. [1]
  T.J. Liang,Hepatol. Baltim. Md. 49 (2009) S13–S21. doi: 10.1002/hep.22881
2. [2]
  Global Hepatitis Report 2017,World Health Organization,19 April 2017,https://www.who.int/publications/i/item/9789241565455.
3. [3]
  Y. Niu,W. Xie,W. Qin,Acta Pharm. Sin. B 1 (2011) 73–79. doi: 10.1016/j.apsb.2011.06.001
4. [4]
  J. Balogh,D. Victor,E.H. Asham,et al.,J. Hepatocell. Carcinoma 3 (2016) 41–53. doi: 10.2147/JHC.S61146
5. [5]
  T. Asselah,D. Loureiro,N. Boyer,A. Mansouri,Lancet Gastroenterol. Hepatol. 4 (2019) 883–892. doi: 10.1016/S2468-1253(19)30190-6
6. [6]
  M.H. Nguyen,G. Wong,E. Gane,et al.,Clin. Microbiol. Rev. 33 (2020) e00046-19.
7. [7]
  J. Cheng,Y. Han,J.D. Jiang,Acta Pharm. Sin. B 4 (2014) 270–276. doi: 10.1016/j.apsb.2014.06.009
8. [8]
  S. Fung,H.S.J. Choi,A. Gehring,H.L.A. Janssen,Hepatology 76 (2022) 233–250. doi: 10.1002/hep.32314
9. [9]
  G.C. Fanning,F. Zoulim,J. Hou,A. Bertoletti,Nat. Rev. Drug Discov. 18 (2019) 827–844. doi: 10.1038/s41573-019-0037-0
10. [10]
  J. Chang,F. Guo,X. Zhao,J.T. Guo,Acta Pharm. Sin. B 4 (2014) 248-257. doi: 10.1016/j.apsb.2014.05.002
11. [11]
  Y. Pei,C. Wang,S.F. Yan,G. Liu,J. Med. Chem. 60 (2017) 6461–6479. doi: 10.1021/acs.jmedchem.6b01442
12. [12]
  B.M. Chain,R. Myers,BMC Microbiol. 5 (2005) 33. doi: 10.1186/1471-2180-5-33
13. [13]
  P.T. Wingfield,S.J. Stahl,R.W. Williams,A.C. Steven,Biochemistry 34 (1995) 4919–4932. doi: 10.1021/bi00015a003
14. [14]
  M. Nassal,J. Virol. 66 (1992) 4107–4116. doi: 10.1128/jvi.66.7.4107-4116.1992
15. [15]
  A. Diab,A. Foca,F. Zoulim,D. Durantel,O. Andrisani,Antiviral Res. 149 (2018) 211–220. doi: 10.1016/j.antiviral.2017.11.015
16. [16]
  A. Zlotnick,J.M. Johnson,P.W. Wingfield,S. J. Stahl,D. Endres,Biochemistry 38 (1999) 14644–14652. doi: 10.1021/bi991611a
17. [17]
  A. Zlotnick,B. Venkatakrishnan,Z. Tan,et al.,Antiviral Res. 121 (2015) 82–93. doi: 10.1016/j.antiviral.2015.06.020
18. [18]
  U. Viswanathan,N. Mani,Z. Hu,et al.,Antiviral Res. 182 (2020) 104917. doi: 10.1016/j.antiviral.2020.104917
19. [19]
  F. Guo,Q. Zhao,M. Sheraz,et al.,PLOS Pathog. 13 (2017) e1006658. doi: 10.1371/journal.ppat.1006658
20. [20]
  J.M. Berke,P. Dehertogh,K. Vergauwen,et al.,Antimicrob. Agents Chemother. 61 (2017) e00560-17. doi: 10.1128/AAC.00560-17
21. [21]
  T. Lahlali,J.M. Berke,K. Vergauwen,et al.,Antimicrob. Agents Chemother. 62 (2018) e00835-18.
22. [22]
  D. Burdette,A. Hyrina,Z. Song,et al.,Antimicrob. Agents Chemother. 67 (2023) e01348-22.
23. [23]
  Y. Wang,S. Wang,X. Tao,et al.,Med. Chem. Res. 31 (2022) 1414–1430. doi: 10.1007/s00044-022-02936-5
24. [24]
  H. Kim,C. Ko,J.Y. Lee,M. Kim,Molecules 26 (2021) 7420. doi: 10.3390/molecules26247420
25. [25]
  L. Yang,F. Liu,X. Tong,et al.,ACS Infect. Dis. 5 (2019) 713–724. doi: 10.1021/acsinfecdis.8b00337
26. [26]
  Z. Qiu,X. Lin,M. Zhou,et al.,J. Med. Chem. 59 (2016) 7651–7666. doi: 10.1021/acs.jmedchem.6b00879
27. [27]
  Z. Zhou,T. Hu,X. Zhou,et al.,Sci. Rep. 7 (2017) 42374. doi: 10.1038/srep42374
28. [28]
  S.P. Katen,Z. Tan,S.R. Chirapu,M. G. Finn,A. Zlotnick,Structure 21 (2013) 1406–1416. doi: 10.1016/j.str.2013.06.013
29. [29]
  V. Taverniti,G. Ligat,Y. Debing,et al.,J. Clin. Med. 11 (2022) 1349. doi: 10.3390/jcm11051349
30. [30]
  D. Ding,S. Xu,X. Zhang,et al.,Expert Opin. Drug Discov. 18 (2023) 5–12. doi: 10.1080/17460441.2023.2157401
31. [31]
  X. Zhang,S. Xu,L. Sun,et al.,Future Med. Chem. 14 (2022) 605–607. doi: 10.4155/fmc-2022-0008
32. [32]
  L. Sun,X. Zhang,S. Xu,et al.,Eur. J. Med. Chem. 217 (2021) 113380. doi: 10.1016/j.ejmech.2021.113380
33. [33]
  S. Xu,L. Sun,B. Huang,et al.,Future Med. Chem. 12 (2020) 1281–1284. doi: 10.4155/fmc-2020-0084
34. [34]
  S. Fox,S. Farr-Jones,L. Sopchak,A. Boggs,J. Comley,SLAS Discov. 9 (2004) 354–358. doi: 10.1177/1087057104265290
35. [35]
  T. Pan,Y. Ding,L. Wu,et al.,Eur. J. Med. Chem. 166 (2019) 480–501. doi: 10.1016/j.ejmech.2019.01.059
36. [36]
  A.D. Huber,D.L. Pineda,D. Liu,et al.,ACS Infect. Dis. 5 (2019) 750–758. doi: 10.1021/acsinfecdis.8b00235
37. [37]
  X. Zhang,J. Cheng,J. Ma,et al.,ACS Infect. Dis. 5 (2019) 759–768. doi: 10.1021/acsinfecdis.8b00269
38. [38]
  Y. Pei,C. Wang,H. Ben,et al.,ACS Infect. Dis. 5 (2019) 778–787. doi: 10.1021/acsinfecdis.9b00030
39. [39]
  M. Yamasaki,N. Matsuda,K. Matoba,et al.,Virus Res. 306 (2021) 198565. doi: 10.1016/j.virusres.2021.198565
40. [40]
  O. Slater,M. Kontoyianni,Expert Opin. Drug Discov. 14 (2019) 619–637. doi: 10.1080/17460441.2019.1604677
41. [41]
  M. Toyama,N. Sakakibara,M. Takeda,et al.,Virus Res. 271 (2019) 197677. doi: 10.1016/j.virusres.2019.197677
42. [42]
  S. Senaweera,H. Du,H. Zhang,et al.,Viruses 13 (2021) 770. doi: 10.3390/v13050770
43. [43]
  Y. Wang,Z. Wang,J. Liu,et al.,Bioorg. Med. Chem. 36 (2021) 116096. doi: 10.1016/j.bmc.2021.116096
44. [44]
  Y. Yang,Y. Yan,J. Yin,et al.,Viruses 14 (2022) 348. doi: 10.3390/v14020348
45. [45]
  D. Yang,L. Wang,P. Yuan,et al.,Chin. Chem. Lett. 34 (2023) 107964. doi: 10.1016/j.cclet.2022.107964
46. [46]
  J. Zhu,C. Chen,J. Dong,et al.,Chin. Chem. Lett. 34 (2023) 107514. doi: 10.1016/j.cclet.2022.05.028
47. [47]
  S. Gao,T. Huang,L. Song,et al.,Acta Pharm. Sin. B 12 (2022) 581–599. doi: 10.1016/j.apsb.2021.08.027
48. [48]
  S. Pushpakom,F. Iorio,P.A. Eyers,et al.,Nat. Rev. Drug Discov. 18 (2019) 41–58. doi: 10.1038/nrd.2018.168
49. [49]
  P. Zhan,B. Yu,L. Ouyang,Drug Discov. Today 27 (2022) 1785–1788. doi: 10.1016/j.drudis.2022.05.026
50. [50]
  X.F. Wei,C.Y. Gan,J. Cui,et al.,Antimicrob. Agents Chemother. 62 (2018) e01302-18.
51. [51]
  J. Blaising,S.J. Polyak,E.I. Pécheur,Antiviral Res. 107 (2014) 84–94. doi: 10.1016/j.antiviral.2014.04.006
52. [52]
  J.A. Kang,S. Kim,M. Park,et al.,Nat. Commun. 10 (2019) 2184. doi: 10.1038/s41467-019-10200-5
53. [53]
  H.W. Seo,J.P. Seo,Y. Cho,et al.,Virus Res. 263 (2019) 102–111. doi: 10.1016/j.virusres.2019.01.004
54. [54]
  X. Mao,D.L. Auer,W. Buchalla,et al.,Agents Chemother. 64 (2020) e00576-20.
55. [55]
  Y. Xiao,C. Liu,W. Tang,H. Zhang,X. Chen,Front. Microbiol. 10 (2019) 2638. doi: 10.3389/fmicb.2019.02638
56. [56]
  D.L. Ma,D.S.H. Chan,C.H. Leung,Chem. Soc. Rev. 42 (2013) 2130–2141. doi: 10.1039/c2cs35357a
57. [57]
  J. Du,J. Guo,D. Kang,et al.,Chin. Chem. Lett. 31 (2020) 1695–1708. doi: 10.1016/j.cclet.2020.03.028
58. [58]
  J.W.H. Li,J.C. Vederas,Science 325 (2009) 161–165. doi: 10.1126/science.1168243
59. [59]
  Z. Guo,Acta Pharm. Sin. B 7 (2017) 119–136. doi: 10.3390/sym9070119
60. [60]
  L. Zhao,X. Xiong,L. Liu,et al.,Chin. Chem. Lett. 33 (2022) 1841–1849. doi: 10.3390/biology11121841
61. [61]
  H.J. Chen,W.L. Wang,G.F. Wang,et al.,ChemMedChem 3 (2008) 1316–1321. doi: 10.1002/cmdc.200800136
62. [62]
  L. Yang,L. Shi,H. Chen,et al.,Acta Pharmacol. Sin. 35 (2014) 410–418. doi: 10.1038/aps.2013.175
63. [63]
  M. Luo,Z. Chen,M. Liu,et al.,J. Med. Virol. 94 (2022) 2727–2735. doi: 10.1002/jmv.27621
64. [64]
  H. Ju,J. Zhang,B. Huang,et al.,J. Med. Chem. 60 (2017) 3533–3551. doi: 10.1021/acs.jmedchem.6b01227
65. [65]
  Y. Yao,Z. Liu,M. Zhao,et al.,Acta Pharm. Sin. B 10 (2020) 1453–1475. doi: 10.1016/j.apsb.2020.04.002
66. [66]
  Y. Tao,X. Hao,X. Ding,et al.,Eur. J. Med. Chem. 201 (2020) 112374. doi: 10.1016/j.ejmech.2020.112374
67. [67]
  L. Li,A. Wang,B. Wang,et al.,Chin. Chem. Lett. 31 (2020) 409–412. doi: 10.1016/j.cclet.2019.07.038
68. [68]
  K. Vandyck,G. Rombouts,B. Stoops,et al.,J. Med. Chem. 61 (2018) 6247–6260. doi: 10.1021/acs.jmedchem.8b00654
69. [69]
  Q. Ren,X. Liu,G. Yan,et al.,J. Med. Chem. 61 (2018) 1355–1374. doi: 10.1021/acs.jmedchem.7b01914
70. [70]
  J. Tang,A.D. Huber,D.L. Pineda,et al.,Eur. J. Med. Chem. 164 (2019) 179–192. doi: 10.1016/j.ejmech.2018.12.047
71. [71]
  H.G. Na,A. Imran,K. Kim,et al.,ACS Med. Chem. Lett. 11 (2020) 166–171. doi: 10.1021/acsmedchemlett.9b00550
72. [72]
  Y.H. Lee,H.M. Cha,J.Y. Hwang,et al.,ACS Med. Chem. Lett. 12 (2021) 242–248. doi: 10.1021/acsmedchemlett.0c00606
73. [73]
  W. Kim,J.A. Kang,M. Park,et al.,J. Med. Chem. 64 (2021) 5500–5518. doi: 10.1021/acs.jmedchem.0c01938
74. [74]
  K. Spunde,B. Vigante,U.N. Dubova,et al.,Pharmaceuticals 15 (2022) 773. doi: 10.3390/ph15070773
75. [75]
  K. Lv,S. Wu,Z. Tao,et al.,Eur. J. Med. Chem. 228 (2022) 113974. doi: 10.1016/j.ejmech.2021.113974
76. [76]
  S.D. Kuduk,L.G. DeRatt,B. Stoops,et al.,Bioorg. Med. Chem. Lett. 72 (2022) 128823. doi: 10.1016/j.bmcl.2022.128823
77. [77]
  S.D. Kuduk,B. Stoops,A.M. Lam,et al.,Bioorg. Med. Chem. Lett. 52 (2021) 128353. doi: 10.1016/j.bmcl.2021.128353
78. [78]
  D. Wu,X. Zheng,R. Liu,et al.,Acta Pharm. Sin. B 12 (2022) 1351–1362. doi: 10.1016/j.apsb.2021.09.027
79. [79]
  Y. Yang,S. Zhang,Q. Zhou,et al.,Acta Pharm. Sin. B 10 (2020) 2339–2347. doi: 10.1016/j.apsb.2020.04.003
80. [80]
  L. Wang,M.C. Casey,S.K.V. Vernekar,et al.,Acta Pharm. Sin. B 11 (2021) 810–822. doi: 10.1016/j.apsb.2020.07.016
81. [81]
  D. Feng,F. Wei,Y. Sun,et al.,Chin. Chem. Lett. 12 (2021) 4053–4057. doi: 10.1016/j.cclet.2021.02.033
82. [82]
  K. Lv,S. Wu,W. Li,et al.,Bioorg. Chem. 94 (2020) 103363. doi: 10.1016/j.bioorg.2019.103363
83. [83]
  W. Chen,F. Liu,Q. Zhao,et al.,J. Med. Chem. 63 (2020) 8134–8145. doi: 10.1021/acs.jmedchem.0c00346
84. [84]
  F. Amblard,S. Boucle,L. Bassit,et al.,Bioorg. Med. Chem. 31 (2021) 115952. doi: 10.1016/j.bmc.2020.115952
85. [85]
  S.J. Hurwitz,N. McBrearty,A. Arzumanyan,et al.,Viruses 13 (2021) 114. doi: 10.3390/v13010114
86. [86]
  Y. Ma,S. Zhao,Y. Ren,et al.,Eur. J. Med. Chem. 225 (2021) 113780. doi: 10.1016/j.ejmech.2021.113780
87. [87]
  A.G. Cole,S.G. Kultgen,N. Mani,et al.,RSC Med. Chem. 13 (2022) 343–349. doi: 10.1039/d1md00318f
88. [88]
  C. Viegas-Junior,A. Danuello,V. da Silva Bolzani,E.J. Barreiro,C.A. Fraga,Curr. Med. Chem. 14 (2007) 1829–1852. doi: 10.2174/092986707781058805
89. [89]
  H. Jia,J. Yu,X. Du,et al.,Eur. J. Med. Chem. 202 (2020) 112495. doi: 10.1016/j.ejmech.2020.112495
90. [90]
  X. Li,Z. Zhang,Y. Chen,et al.,ACS Med. Chem. Lett. 13 (2022) 507–512. doi: 10.1021/acsmedchemlett.2c00002
91. [91]
  L. Liu,M. Wang,C. Li,et al.,Bioorganic Chem. 128 (2022) 106052. doi: 10.1016/j.bioorg.2022.106052
92. [92]
  S. Wang,Y. Ren,Q. Li,et al.,Bioorganic Chem. 129 (2022) 106192. doi: 10.1016/j.bioorg.2022.106192
93. [93]
  S. Zhang,J. Zhang,P. Gao,et al.,Drug Discov. Today 24 (2019) 805–813. doi: 10.1016/j.drudis.2018.11.021
94. [94]
  H. Guo,X. Zhuang,K. Qian,et al.,Acta Pharm. Sin. B 2 (2012) 213–219. doi: 10.1016/j.apsb.2012.02.008
95. [95]
  J.B. Zawilska,J. Wojcieszak,A.B. Olejniczak,Pharmacol. Rep. 65 (2013) 1–14. doi: 10.1016/s1734-1140(13)70959-9
96. [96]
  X. Ji,X. Jiang,C. Kobayashi,et al.,Molecules 27 (2022) 5987. doi: 10.3390/molecules27185987
97. [97]
  Z. Fang,Y. Song,P. Zhan,Q. Zhang,X. Liu,Future Med. Chem. 6 (2014) 885–901. doi: 10.4155/fmc.14.50
98. [98]
  K. Tang,S. Wang,W. Gao,Y. Song,B. Yu,Acta Pharm. Sin. B 12 (2022) 4309–4326. doi: 10.1016/j.apsb.2022.09.022
99. [99]
  C. Wang,Y. Pei,L. Wang,et al.,J. Med. Chem. 63 (2020) 6066–6089. doi: 10.1021/acs.jmedchem.0c00292
100. [100]
  B. Huang,D. Kang,P. Zhan,X. Liu,Expert Opin. Drug Discov. 10 (2015) 1271–1281. doi: 10.1517/17460441.2015.1083007
101. [101]
  Q. Nie,S. Zhong,Y. Li,G. Zhang,Y. Li,Chin. Chem. Lett. 33 (2022) 2559–2563. doi: 10.1016/j.cclet.2021.09.041
102. [102]
  K. Klumpp,T. Crépin,Curr. Opin. Virol. 5 (2014) 63–71. doi: 10.1016/j.coviro.2014.02.002
103. [103]
  A.C.H. Lee,E.P. Thi,A. Ardzinski,et al.,J. Hepatol. 73 (2020) S833.
104. [104]
  C. Abadzapatero,J. Metz,Drug Discov. Today 10 (2005) 464–469. doi: 10.1016/S1359-6446(05)03386-6
105. [105]
  P.D. Leeson,B. Springthorpe,Nat. Rev. Drug Discov. 6 (2007) 881–890. doi: 10.1038/nrd2445
106. [106]
  X. Jiang,J. Yu,Z. Zhou,et al.,Med. Res. Rev. 39 (2019) 2194–2238. doi: 10.1002/med.21581
107. [107]
  W. Wei,S. Cherukupalli,L. Jing,X. Liu,P. Zhan,Drug Discov. Today 25 (2020) 1839–1845. doi: 10.1016/j.drudis.2020.07.017
108. [108]
  Y. Wang,X. Jiang,F. Feng,W. Liu,H. Sun,Acta Pharm. Sin. B 10 (2020) 207–238. doi: 10.3390/molecules25010207
109. [109]
  M. de Wispelaere,G. Du,K.A. Donovan,et al.,Nat. Commun. 10 (2019) 3468. doi: 10.1038/s41467-019-11429-w
110. [110]
  H. Wu,H. Yao,C. He,et al.,Acta Pharm. Sin. B 12 (2022) 3548–3566. doi: 10.1016/j.apsb.2022.03.019
111. [111]
  S. De Cesco,J. Kurian,C. Dufresne,et al.,Eur. J. Med. Chem. 138 (2017) 96–114. doi: 10.1016/j.ejmech.2017.06.019
1. [1]
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2. [2]
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4. [4]
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5. [5]
  Wei Chen , Pieter Cnudde . A minireview to ketene chemistry in zeolite catalysis. Chinese Journal of Structural Chemistry, 2024, 43(11): 100412-100412. doi: 10.1016/j.cjsc.2024.100412
6. [6]
  Bharathi Natarajan , Palanisamy Kannan , Longhua Guo . Metallic nanoparticles for visual sensing: Design, mechanism, and application. Chinese Journal of Structural Chemistry, 2024, 43(9): 100349-100349. doi: 10.1016/j.cjsc.2024.100349
7. [7]
  Peiwen Liu , Fang Zhao , Jing Zhang , Yunpeng Bai , Jinxing Ye , Bo Bao , Xinggui Zhou , Li Zhang , Changlu Zhou , Xinhai Yu , Peng Zuo , Jianye Xia , Lian Cen , Yangyang Yang , Guoyue Shi , Lin Xu , Weiping Zhu , Yufang Xu , Xuhong Qian . Micro/nano flow chemistry by Beyond Limits Manufacturing. Chinese Chemical Letters, 2024, 35(5): 109020-. doi: 10.1016/j.cclet.2023.109020
8. [8]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
9. [9]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
10. [10]
  Xin Zhang , Junyu Chen , Xiang Pei , Linxin Yang , Liang Wang , Luona Chen , Guangmei Yang , Xibo Pei , Qianbing Wan , Jian Wang . Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration. Chinese Chemical Letters, 2024, 35(6): 108889-. doi: 10.1016/j.cclet.2023.108889
11. [11]
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19. [19]
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沈阳化工大学材料科学与工程学院沈阳 110142