Citation: Xuwen Da, Xiulian Liu, Chao Li, Yatong Peng, Yao Jian, Wanpeng Zhou, Yunli Xu, Yao Wu, Xuesong Wang, Qianxiong Zhou. Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions[J]. Chinese Chemical Letters, ;2023, 34(12): 108317. doi: 10.1016/j.cclet.2023.108317 shu

Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China

xswang@mail.ipc.ac.cn

zhouqianxiong@mail.ipc.ac.cn

Received Date: 29 December 2022
Revised Date: 1 March 2023
Accepted Date: 7 March 2023
Available Online: 12 March 2023

Figures(5)

Photo-catalytic oxidation of intracellular nicotinamide adenine dinucleotide (2′-phosphate) (NAD(P)H) has attracted much attention for cancer therapy. However, the general oxygen-dependent mechanism heavily depresses the efficacy in hypoxic tumors. To solve this problem, herein platinum nanoparticles (Pt NPs) with catalase-like (CAT-like) and catalytic H₂ evolution activities were introduced as a powerful assistant to enhance the photo-catalytic NAD(P)H oxidation of Ru1 ([Ru(phen)₂(PIP-OCH₃)]²⁺, phen = 1,10-phenanthroline, PIP-OCH₃ = 2-(4–methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) under hypoxic and even oxygen-free conditions. Firstly, Pt NPs can transform the original and in situ formed H₂O₂ once again into O₂ by the CAT-like activity, thus relieving tumor hypoxia and realizing cyclic utilization (at least in part) of the precious oxygen in hypoxia. Secondly, Pt NPs can also be served as H₂ evolution catalysts while using Ru1 as the photosensitizer and NAD(P)H as the electron and proton donor. In this process, NAD(P)H is oxidized without the participation of oxygen, which can provide an effective way even under oxygen-free conditions. Via co-encapsulation of Ru1 and Pt NPs in bovine serum albumin (BSA) with tumor targeting ability, the resultant Ru/Pt@BSA could photo-catalyze intracellular NAD(P)H oxidation under hypoxic conditions (3% O₂), and exhibited an efficient and selective anticancer activity both in vitro and in vivo. Our results may provide new sights for efficient and targeted cancer treatment under hypoxic conditions.
- Hypoxic,
- Cancer treatment,
- Photo-catalytic oxidation NAD(P)H,
- Cyclic utilization of oxygen,
- Pt nanoparticle
1. [1]
  Q. Sun, Z. Wang, B. Liu, et al., Coord. Chem. Rev. 451 (2022) 214267. doi: 10.1016/j.ccr.2021.214267
2. [2]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71 (2021) 209–249. doi: 10.3322/caac.21660
3. [3]
  F. Bray, J. Ferlay, I. Soerjomataram, et al., CA Cancer J. Clin. 68 (2018) 394–424. doi: 10.3322/caac.21492
4. [4]
  S.L. Li, P. Jiang, F.L. Jiang, Y. Liu, Adv. Funct. Mater. 31 (2021) 2100243. doi: 10.1002/adfm.202100243
5. [5]
  R.W. Johnstone, A.A. Ruefli, S.W. Lowe, Cell 108 (2022) 153–164.
6. [6]
  Y. Zhou, S. Fan, L. Feng, X. Huang, X. Chen, Adv. Mater. 33 (2021) 2104223. doi: 10.1002/adma.202104223
7. [7]
  W. Bao, M. Liu, J. Meng, et al., Nat. Commun. 12 (2021) 6399. doi: 10.1038/s41467-021-26655-4
8. [8]
  K. Ni, T. Aung, S. Li, et al., Chem 5 (2019) 1892–1913. doi: 10.1016/j.chempr.2019.05.013
9. [9]
  K. Ni, T. Luo, G.T. Nash, W. Lin, Acc. Chem. Res. 53 (2020) 1739–1748. doi: 10.1021/acs.accounts.0c00313
10. [10]
  W. Wu, L. Yu, Q. Jiang, et al., J. Am. Chem. Soc. 141 (2019) 11531–11539. doi: 10.1021/jacs.9b03503
11. [11]
  S. Li, B. Xu, M. Lu, et al., Adv. Mater. 34 (2022) e2202609. doi: 10.1002/adma.202202609
12. [12]
  Y. Zhao, X. Liu, X. Liu, et al., Front. Immunol. 13 (2022) 955920. doi: 10.3389/fimmu.2022.955920
13. [13]
  C. Wang, Y. Zhang, H. Li, et al., Chin. Chem. Lett. 33 (2022) 2447–2450. doi: 10.1016/j.cclet.2021.09.106
14. [14]
  H. Wang, Zhang H, W. Xing, et al., Chin. Chem. Lett. 33 (2022) 4033–4036. doi: 10.1016/j.cclet.2021.12.051
15. [15]
  D. Xu, Q. Zhou, X. Dal, et al., Chin. Chem. Lett. 33 (2022) 851–854. doi: 10.1016/j.cclet.2021.08.001
16. [16]
  H. Huang, S. Banerjee, K. Qiu, et al., Nat. Chem. 11 (2019) 1041–1048. doi: 10.1038/s41557-019-0328-4
17. [17]
  A. Chiarugi, C. Dölle, R. Felici, M. Ziegler, Nat. Rev. Cancer 12 (2012) 741–752. doi: 10.1038/nrc3340
18. [18]
  A.O. Elzoghby, W.M. Samy, N.A. Elgindy, J. Control. Release 157 (2012) 168–182. doi: 10.1016/j.jconrel.2011.07.031
19. [19]
  Z. Fan, Y. Rong, T. Sadhukhan, et al., Angew. Chem. Int. Ed. 61 (2022) e202202098. doi: 10.1002/anie.202202098
20. [20]
  C. Huang, C. Liang, T. Sadhukhan, et al., Angew. Chem. Int. Ed. 60 (2021) 9474–9479. doi: 10.1002/anie.202015671
21. [21]
  L. Lee, K. Lo, J. Am. Chem. Soc. 144 (2022) 14420–14440. doi: 10.1021/jacs.2c03437
22. [22]
  A.K. Mengele, D. Weixler, A. Chettri, et al., Chem. Eur. J. 27 (2021) 16840–16845. doi: 10.1002/chem.202103029
23. [23]
  S. Qi, Z. Jin, Y. Jian, et al., Chem. Commun. 57 (2021) 4162–4165. doi: 10.1039/D1CC00258A
24. [24]
  C. Liang, J. Xie, S. Luo, et al., Nat. Commun. 12 (2021) 5001. doi: 10.1038/s41467-021-25303-1
25. [25]
  X. Da, Z. Wang, Y. Jian, et al., Inorg. Chem. Front. 9 (2022) 2544–2556. doi: 10.1039/D2QI00413E
26. [26]
  K. Teng, L. Niu, N. Xie, Q. Yang, Nat. Commun. 13 (2022) 6179. doi: 10.1038/s41467-022-33924-3
27. [27]
  M. Li, K.H. Gebremedhin, D. Ma, et al., J. Am. Chem. Soc. 144 (2022) 163–173. doi: 10.1021/jacs.1c07372
28. [28]
  M. Li, Y. Xu, Z. Pu, et al., Proc. Natl. Acad. Sci. U. S. A. 119 (2022) e2210504119. doi: 10.1073/pnas.2210504119
29. [29]
  H. Fan, G. Yan, Z. Zhao, et al., Angew. Chem. Int. Ed. 55 (2016) 5477–5482. doi: 10.1002/anie.201510748
30. [30]
  S. Hou, Y.E. Gao, X. Ma, et al., Chem. Eng. J. 416 (2021) 129037. doi: 10.1016/j.cej.2021.129037
31. [31]
  F. Jiang, B. Ding, S. Liang, et al., Biomaterials 268 (2021) 120545. doi: 10.1016/j.biomaterials.2020.120545
32. [32]
  P. Zhao, Z. Tang, X. Chen, et al., Mater. Horizons. 6 (2019) 369–374. doi: 10.1039/C8MH01176A
33. [33]
  K. Teng, Chen W, L. Niu, et al., Angew. Chem. Int. Ed. 60 (2021) 19912–19920. doi: 10.1002/anie.202106748
34. [34]
  K. Teng, L. Niu, Q. Yang, et al., Chem. Sci. 13 (2022) 5951–5956. doi: 10.1039/D2SC01469F
35. [35]
  Y. Cheng, H. Cheng, C. Jiang, et al., Nat. Commun. 6 (2015) 8785. doi: 10.1038/ncomms9785
36. [36]
  R. Liang, L. Liu, H. He, et al., Biomaterials 177 (2018) 149–160. doi: 10.1016/j.biomaterials.2018.05.051
37. [37]
  F. Shen, C. Zhang, Z. Cai, et al., Chem. Eng. J. 438 (2022) 135556. doi: 10.1016/j.cej.2022.135556
38. [38]
  Z. Wang, Y. Yan, C. Li, et al., ACS Nano 16 (2022) 9019–9130. doi: 10.1021/acsnano.2c00327
39. [39]
  L. Gong, Y. Zhang, J. Zhao, et al., Small 18 (2022) e2107656. doi: 10.1002/smll.202107656
40. [40]
  F. Bonnay, A. Veloso, V. Steinmann, et al., Cell 182 (2020) 1490–1507. doi: 10.1016/j.cell.2020.07.039
41. [41]
  L. Liu, Y. Wang, Y. Zhao, et al., Adv. Funct. Mater. 32 (2022) 2112207. doi: 10.1002/adfm.202112207
42. [42]
  T. Zhang, C. Pei, G. Sun, et al., Angew. Chem. Int. Ed. 61 (2022) e202201453. doi: 10.1002/anie.202201453
43. [43]
  S. Wang, Y. Pang, S. Hu, et al., Chem. Eng. J. 451 (2023) 138864. doi: 10.1016/j.cej.2022.138864
44. [44]
  C. Zhang, X. Guo, X. Da, et al., Dalton Trans. 50 (2021) 7715–7724. doi: 10.1039/D1DT00777G
45. [45]
  X. Liu, X. Dong, S. Yang, et al., Adv. Sci. 8 (2021) 2003679. doi: 10.1002/advs.202003679
46. [46]
  Y. Teow, S. Valiyaveettil, Nanoscale 2 (2010) 2607–2613. doi: 10.1039/c0nr00204f
47. [47]
  P.R. Van, M.J. Mckelvy, W.S. Glaunsinger, J. Solid State Chem. 67 (1986) 151–169. doi: 10.1016/0022-4596(87)90350-1
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