Citation: Songtao Zhou, Hao Tian, Jie Yan, Zhan Zhang, Guohao Wang, Xinying Yu, Wei Sang, Bei Li, Greta S.P. Mok, Jie Song, Yunlu Dai. IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy[J]. Chinese Chemical Letters, ;2024, 35(1): 108312. doi: 10.1016/j.cclet.2023.108312 shu

IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

Songtao Zhou ^{a, b, c, 1} ,
Hao Tian ^{a, b, 1} ,
Jie Yan ^{a, b} ,
Zhan Zhang ^{a, b} ,
Guohao Wang ^{a, b} ,
Xinying Yu ^{a, b} ,
Wei Sang ^{a, b} ,
Bei Li ^{a, b} ,
Greta S.P. Mok ^d ,
Jie Song ^{c, *,} ,
Yunlu Dai ^{a, b, **,}

a.
Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China
b.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau 999078, China
c.
Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou 310022, China
d.
Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau 999078, China

^**

sjie@sjtu.edu.cn

yldai@um.edu.mo

Received Date: 29 December 2022
Revised Date: 4 March 2023
Accepted Date: 7 March 2023
Available Online: 12 March 2023

Figures(5)

Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROS) to damage biomolecules like DNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT. However, the photosensitizer and chemotherapy drugs used in PDT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.
- Metal phenolic network,
- IR780,
- Photodynamic therapy,
- Breast cancer,
- Gemcitabine
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