Citation: Shuang Cheng, Meng Pan, Danrong Hu, Ruxia Han, Lang Li, Zhongwu Bei, Yicong Li, Ao Sun, Zhiyong Qian. Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing[J]. Chinese Chemical Letters, ;2023, 34(12): 108276. doi: 10.1016/j.cclet.2023.108276 shu

Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing

Shuang Cheng ^a ,
Meng Pan ^a ,
Danrong Hu ^{a, b} ,
Ruxia Han ^a ,
Lang Li ^{a, c} ,
Zhongwu Bei ^a ,
Yicong Li ^a ,
Ao Sun ^a ,
Zhiyong Qian ^{a, *,}

a.
State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China
c.
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

Received Date: 12 November 2022
Revised Date: 22 February 2023
Accepted Date: 27 February 2023
Available Online: 2 March 2023

Figures(6)

Bacterial infection of wounds is an escalating medical problem, issuing threats to both global public health and personal health. Photothermal antibacterial technology as a novel sterilization strategy has outstanding sterilization efficiency, high safety and low risk of emergence of drug-resistant bacteria. By combining inherent antibacterial activity and light-assisted antibacterial treatment, developing novel multifunctional dressings with synergistic high-efficiency antibacterial effects and also promoting wound healing possesses attractive advantages in the field of treating bacterial wound infections in clinical care. Herein, a multifunctional hydrogel formed by in situ photo-cross linking was designed and prepared by first grafting methacrylic anhydride as a photosensitizer onto chitosan, and then introducing oxidatively synthesized polydopamine (PDA). The physicochemical characterizations of the synthesized hydrogels demonstrated their tunability certainly associated with PDA concentration, including pore size, water swelling, rheological properties and in vitro degradability. In addition, the composite hydrogels exhibited good adhesion, anti-oxidation and photothermal properties due to the existence of PDA. Within 10 min upon exposure to 808 nm near-infrared (NIR) light irradiation, this hydrogel system displayed outstanding antibacterial activity against Staphylococcus aureus with almost 100% killing efficiency, of which rapid efficient sterilization plays a significant role in wound healing. Moreover, the hydrogel is capable of cytocompatibility and has low toxicity to murine fibroblasts (L929 and NIH/3T3). In the full-thickness wound defect infection model in mice, the wound closure ratio, inflammatory response, fibroblasts, neovascularization and epithelialization were measured. Animal experiments also reveal that the hydrogel assisted with NIR laser irradiation can inhibit effectively infection at an early stage and accelerate the wound healing process. In summary, this novel multifunctional injectable hydrogel exhibits excellent swelling capacity, bio-adhesion, antioxidant property, photothermal activity, efficient antibacterial property and facilitates skin healing, which has great promising application as a medical dressing biomaterial in infected wound care fields.
- Hydrogel,
- Adhesion,
- Photothermal therapy,
- Antibacterial,
- Wound infection
1. [1]
  R. Yu, H. Zhang, B. Guo, Nano Micro Lett. 14 (2021) 1.
2. [2]
  S.H. Lu, M. Samandari, C. Li, et al., Sens. Actuators Rep. 4 (2022) 100075. doi: 10.1016/j.snr.2022.100075
3. [3]
  A. Andrade, M. Egito, W. Vilela, et al., Biointerface Res. Appl. Chem. 12 (2022) 4463–4475.
4. [4]
  M.J. Gotlin, W. Catalano, J.P. Levine, K.A. Egol, Injury 53 (2022) 313–322. doi: 10.1016/j.injury.2021.11.062
5. [5]
  S. Das, A.B. Baker, Front. Bioeng. Biotechnol. 4 (2016) 82.
6. [6]
  S. Rathinavel, J. Indrakumar, P.S. Korrapati, S. Dharmalingam, Colloids Surf. A 637 (2022) 128185. doi: 10.1016/j.colsurfa.2021.128185
7. [7]
  W. Elloumi, A. Mahmoudi, S. Ortiz, et al., Biomed. Pharmacother. 146 (2022) 112574. doi: 10.1016/j.biopha.2021.112574
8. [8]
  B. Li, H. Li, H. Yang, et al., Biomed. Mater. 17 (2022) 025005. doi: 10.1088/1748-605X/ac49f7
9. [9]
  Y. Wang, L. Su, Y. Hou, et al., Macromol. Biosci. 22 (2022) 2100352. doi: 10.1002/mabi.202100352
10. [10]
  J. Zhong, H. Wang, K. Yang, et al., Bioact. Mater. 9 (2022) 523–540.
11. [11]
  M. Hosseini, A. Shafiee, Small 17 (2021) 2101384. doi: 10.1002/smll.202101384
12. [12]
  X. Wang, F. Lv, T. Li, et al., ACS Nano 11 (2017) 11337–11349. doi: 10.1021/acsnano.7b05858
13. [13]
  X. Liu, M. Wu, M. Wang, et al., Adv. Mater. 34 (2022) 2109010. doi: 10.1002/adma.202109010
14. [14]
  S. Du, N. Zhou, G. Xie, et al., Nano Energy 85 (2021) 106004. doi: 10.1016/j.nanoen.2021.106004
15. [15]
  R. Yuan, N. Yang, S. Fan, et al., Small 17 (2021) 2103997. doi: 10.1002/smll.202103997
16. [16]
  O. Castaño, S. PérezAmodio, C. NavarroRequena, M. Á. MateosTimoneda, E. Engel, Adv. Drug Deliv. Rev. 129 (2018) 95–117. doi: 10.1016/j.addr.2018.03.012
17. [17]
  R.E. Jones, D.S. Foster, M.T. Longaker, JAMA 320 (2018) 1481–1482. doi: 10.1001/jama.2018.12426
18. [18]
  J. Zhang, Y. Zheng, J. Lee, et al., Nat. Commun. 12 (2021) 1670. doi: 10.1038/s41467-021-21964-0
19. [19]
  P.K. Gajendrareddy, C.K. Sen, M.P. Horan, P.T. Marucha, Brain Behav. Immun. 19 (2005) 217–222. doi: 10.1016/j.bbi.2004.09.003
20. [20]
  J. Lu, Y. Chen, M. Ding, et al., Carbohydr. Polym. 277 (2022) 118871. doi: 10.1016/j.carbpol.2021.118871
21. [21]
  X. Wang, J. Qi, W. Zhang, et al., Int. J. Biol. Macromol. 187 (2021) 91–104. doi: 10.1016/j.ijbiomac.2021.07.115
22. [22]
  S. Radmanesh, S. Shabangiz, N. Koupaei, S.A. HassanzadehTabrizi, J. Polym. Res. 29 (2022) 50. doi: 10.1007/s10965-022-02899-6
23. [23]
  Y. Li, H. Zheng, Y. Liang, et al., Chin. Chem. Lett. 33 (2022) 5030–5034. doi: 10.1016/j.cclet.2022.03.116
24. [24]
  Y.K. Li, H.Y. Zheng, Y.X. Liang, et al., Chin. Chem. Lett. 33 (2022) 5030–5034. doi: 10.1016/j.cclet.2022.03.116
25. [25]
  C. Wang, J. Chen, X. Yue, et al., AAPS PharmSciTech 23 (2022) 68. doi: 10.1208/s12249-021-02205-5
26. [26]
  J. Li, X. Liu, L. Tan, et al., Nat. Commun. 10 (2019) 4490. doi: 10.1038/s41467-019-12429-6
27. [27]
  Y. Li, R. Fu, Z. Duan, C. Zhu, D. Fan, Colloids Surf. B 210 (2022) 112230. doi: 10.1016/j.colsurfb.2021.112230
28. [28]
  M. Hou, Y. Zhong, L. Zhang, et al., Chin. Chem. Lett. 32 (2021) 1055–1060. doi: 10.1016/j.cclet.2020.08.009
29. [29]
  C. Yang, S. Shang, D. Shou, et al., Mater. Chem. Phys. 277 (2022) 125484. doi: 10.1016/j.matchemphys.2021.125484
30. [30]
  G.S. de Souza, L. de Jesus Sonego, A.C. Santos Mundim, et al., Peptides 148 (2022) 170707. doi: 10.1016/j.peptides.2021.170707
31. [31]
  N. Guo, Y. Xia, Y. Duan, et al., Chin. Chem. Lett. 34 (2023) 107542. doi: 10.1016/j.cclet.2022.05.056
32. [32]
  Y. Liang, Y. Liang, H. Zhang, B. Guo, Asian J. Pharm. Sci. 17 (2022) 353–384. doi: 10.1016/j.ajps.2022.01.001
33. [33]
  Y. Yu, P. Li, C. Zhu, et al., Adv. Funct. Mater. 29 (2019) 1904402. doi: 10.1002/adfm.201904402
34. [34]
  D. Hu, L. Zou, B. Li, et al., ACS Biomater. Sci. Eng. 5 (2019) 5169–5179. doi: 10.1021/acsbiomaterials.9b01173
35. [35]
  Y. Xiang, C. Mao, X. Liu, et al., Small 15 (2019) 1900322. doi: 10.1002/smll.201900322
36. [36]
  Y. Liu, Y. Xi, J. Zhao, et al., Chem. Eng. J. 375 (2019) 122048. doi: 10.1016/j.cej.2019.122048
37. [37]
  B. Zhuang, T. Chen, Y. Huang, Z. Xiao, Y. Jin, Acta Pharm. Sin. B 12 (2022) 1447–1459. doi: 10.1016/j.apsb.2021.09.001
38. [38]
  X. Qi, Y. Huang, S. You, et al., Adv. Sci. 9 (2022) 2106015. doi: 10.1002/advs.202106015
39. [39]
  S. Chen, S. Liu, L. Zhang, et al., Chem. Eng. J. 399 (2020) 125795. doi: 10.1016/j.cej.2020.125795
40. [40]
  M. Suneetha, K.M. Rao, S.S. Han, ACS Omega 4 (2019) 12647–12656. doi: 10.1021/acsomega.9b01302
41. [41]
  F. Zhou, Y. Yang, W. Zhang, et al., Appl. Mater. Today 26 (2022) 101290. doi: 10.1016/j.apmt.2021.101290
42. [42]
  Y. Ren, H. Liu, X. Liu, et al., Cell Rep. Phys. Sci. 1 (2020) 100245. doi: 10.1016/j.xcrp.2020.100245
43. [43]
  S.P. Miguel, A.F. Moreira, I.J. Correia, Int. J. Biol. Macromol. 127 (2019) 460–475. doi: 10.1016/j.ijbiomac.2019.01.072
44. [44]
  K. Zheng, Y. Tong, S. Zhang, et al., Adv. Funct. Mater. 31 (2021) 2102599. doi: 10.1002/adfm.202102599
45. [45]
  J. Qu, X. Zhao, Y. Liang, et al., Biomaterials 183 (2018) 185–199. doi: 10.1016/j.biomaterials.2018.08.044
46. [46]
  L. Han, M. Wang, P. Li, et al., ACS Appl. Mater. Interfaces 10 (2018) 28015–28026. doi: 10.1021/acsami.8b05314
47. [47]
  L.M.Y. Yu, K. Kazazian, M.S. Shoichet, J. Biomed. Mater. Res. Part A 82A (2007) 243–255. doi: 10.1002/jbm.a.31069
48. [48]
  O.M. Kolawole, W.M. Lau, V.V. Khutoryanskiy, Int. J. Pharm. 550 (2018) 123–129. doi: 10.1016/j.ijpharm.2018.08.034
49. [49]
  Y.Y. Yeh, Y.T. Tsai, C.Y. Wu, et al., Macromol. Biosci. 22 (2022) 2100477. doi: 10.1002/mabi.202100477
50. [50]
  Z. Zou, L. Wang, Z. Zhou, et al., Bioact. Mater. 6 (2021) 1839–1851.
51. [51]
  X. Zhao, Y. Liang, B. Guo, et al., Chem. Eng. J. 403 (2021) 126329. doi: 10.1016/j.cej.2020.126329
52. [52]
  L. Yuan, Y. Wu, Q. s. Gu, et al., Int. J. Biol. Macromol. 96 (2017) 569–577. doi: 10.1016/j.ijbiomac.2016.12.058
53. [53]
  A. Lejardi, R. Hernández, M. Criado, et al., Carbohydr. Polym. 103 (2014) 267–273. doi: 10.1016/j.carbpol.2013.12.040
54. [54]
  Z. Ling, Z. Chen, J. Deng, et al., Chem. Eng. J. 420 (2021) 130302. doi: 10.1016/j.cej.2021.130302
55. [55]
  Y. Liang, X. Zhao, T. Hu, Y. Han, B. Guo, J. Colloid Interface Sci. 556 (2019) 514–528. doi: 10.1016/j.jcis.2019.08.083
56. [56]
  X. Jing, H.Y. Mi, B.N. Napiwocki, X.F. Peng, L.S. Turng, Carbon 125 (2017) 557–570. doi: 10.1016/j.carbon.2017.09.071
57. [57]
  Y. Liang, X. Zhao, T. Hu, et al., Small 15 (2019) 1900046. doi: 10.1002/smll.201900046
58. [58]
  Y.L. Mao, Z.Y. Xu, Z.H. He, J. Wang, Z. Zhu, Chin. Chem. Lett. 34 (2023) 107461. doi: 10.1016/j.cclet.2022.04.059
59. [59]
  Y. Chen, Y. Qiu, Q. Wang, et al., Chem. Eng. J. 399 (2020) 125668. doi: 10.1016/j.cej.2020.125668
60. [60]
  C. Chen, P. Zhou, C. Huang, et al., Carbohydr. Polym. 273 (2021) 118557. doi: 10.1016/j.carbpol.2021.118557
61. [61]
  T. Liu, G. Liu, J. Zhang, et al., Chin. Chem. Lett. 33 (2022) 1880–1884. doi: 10.1016/j.cclet.2021.10.022
62. [62]
  R. Gharibi, H. Yeganeh, A. RezapourLactoee, Z.M. Hassan, ACS Appl. Mater. Interfaces 7 (2015) 24296–24311. doi: 10.1021/acsami.5b08376
63. [63]
  B. Kim, B. Kang, T.P. Vales, et al., Macromol. Res. 26 (2018) 35–39. doi: 10.1007/s13233-018-6001-8
64. [64]
  P. Tang, L. Han, P. Li, et al., ACS Appl. Mater. Interfaces 11 (2019) 7703–7714. doi: 10.1021/acsami.8b18931
65. [65]
  Y. Liang, Z. Li, Y. Huang, R. Yu, B. Guo, ACS Nano 15 (2021) 7078–7093. doi: 10.1021/acsnano.1c00204
66. [66]
  Q. Pang, K. Wu, Z. Jiang, et al., Macromol. Biosci. 22 (2022) 2100386. doi: 10.1002/mabi.202100386
67. [67]
  C. Guo, J. Zhang, X. Feng, et al., Chin. Chem. Lett. 33 (2022) 2975–2981. doi: 10.1016/j.cclet.2021.12.086
68. [68]
  L. Fan, Z. He, X. Peng, et al., ACS Appl. Mater. Interfaces 13 (2021) 53541–53552. doi: 10.1021/acsami.1c14216
69. [69]
  Y. Fu, L. Yang, J. Zhang, et al., Mater. Horiz. 8 (2021) 1618–1633. doi: 10.1039/D0MH01985B
70. [70]
  Y. Kong, Z. Hou, L. Zhou, et al., ACS Biomater. Sci. Eng. 7 (2021) 335–349. doi: 10.1021/acsbiomaterials.0c01473
71. [71]
  P.K. Sharma, M. Halder, U. Srivastava, Y. Singh, ACS Appl. Bio Mater. 2 (2019) 5313–5322. doi: 10.1021/acsabm.9b00570
72. [72]
  H. Huang, D. He, X. Liao, H. Zeng, Z. Fan, Mater. Sci. Eng. C 129 (2021) 112395. doi: 10.1016/j.msec.2021.112395
73. [73]
  A.G. Rusu, A.P. Chiriac, L.E. Nita, et al., Int. J. Biol. Macromol. 132 (2019) 374–384. doi: 10.1016/j.ijbiomac.2019.03.136
74. [74]
  N. Pettinelli, S. RodríguezLlamazares, V. Abella, et al., Mater. Sci. Eng. C 96 (2019) 583–590. doi: 10.1016/j.msec.2018.11.071
75. [75]
  K. Bankoti, A.P. Rameshbabu, S. Datta, et al., J. Mater. Chem. B 8 (2020) 9277–9294. doi: 10.1039/D0TB01574A
76. [76]
  X. Zhao, H. Wu, B. Guo, et al., Biomaterials 122 (2017) 34–47. doi: 10.1016/j.biomaterials.2017.01.011
77. [77]
  Y. Liang, J. He, B. Guo, ACS Nano 15 (2021) 12687–12722. doi: 10.1021/acsnano.1c04206
78. [78]
  J. Wu, Z. Xiao, A. Chen, et al., Acta Biomater. 71 (2018) 293–305. doi: 10.1016/j.actbio.2018.02.034
79. [79]
  Y. Shen, G. Xu, H. Huang, et al., ACS Nano 15 (2021) 6352–6368. doi: 10.1021/acsnano.0c07714
80. [80]
  X. Chen, X. Cao, H. Jiang, et al., Molecules 23 (2018) 2611. doi: 10.3390/molecules23102611
81. [81]
  W. Zhou, L. Zi, Y. Cen, C. You, M. Tian, Front. Bioeng. Biotechnol. 8 (2020) 417. doi: 10.3389/fbioe.2020.00417
82. [82]
  E.Y.X. Loh, N. Mohamad, M.B. Fauzi, et al., Sci. Rep. 8 (2018) 2875. doi: 10.1038/s41598-018-21174-7
83. [83]
  S. Korntner, C. Lehner, R. Gehwolf, et al., Adv. Drug Deliv. Rev. 146 (2019) 170–189. doi: 10.1016/j.addr.2018.02.010
84. [84]
  K. Wu, M. Fu, Y. Zhao, et al., Bioact. Mater. 20 (2023) 93–110.
85. [85]
  A.C. Strömdahl, L. Ignatowicz, G. Petruk, et al., Acta Biomater. 128 (2021) 314–331. doi: 10.1016/j.actbio.2021.04.045
86. [86]
  S. Yao, Y. Zhao, Y. Xu, et al., Adv. Healthcare Mater. 11 (2022) 2200516. doi: 10.1002/adhm.202200516
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  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
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