Citation: Le Hu, Yuxin Wang, Qing Liu, Man Liu, Faming Yang, Chunxiao Wang, Panpan Pan, Lin Wang, Li Chen, Jingdi Chen. Real-time monitoring flexible hydrogels based on dual physically cross-linked network for promoting wound healing[J]. Chinese Chemical Letters, ;2023, 34(10): 108262. doi: 10.1016/j.cclet.2023.108262 shu

Real-time monitoring flexible hydrogels based on dual physically cross-linked network for promoting wound healing

Le Hu ^{a, 1} ,
Yuxin Wang ^{a, 1} ,
Qing Liu ^a ,
Man Liu ^a ,
Faming Yang ^a ,
Chunxiao Wang ^a ,
Panpan Pan ^{a, *,} ,
Lin Wang ^a ,
Li Chen ^c ,
Jingdi Chen ^{a, b, *,}

a.
Marine College, Shandong University, Weihai 264209, China;
b.
Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai 265599, China;
c.
College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China

pppan@sdu.edu.cn

jdchen@sdu.edu.cn

^†

Received Date: 19 November 2022
Revised Date: 16 February 2023
Accepted Date: 22 February 2023
Available Online: 2 March 2023

Figures(5)

To achieve smart and personalized medicine, the development of hydrogel dressings with sensing properties and biotherapeutic properties that can act as a sensor to monitor of human health in real-time while speeding up wound healing face great challenge. In the present study, a biocompatible dual-network composite hydrogel (DNCGel) sensor was obtained via a simple process. The dual network hydrogel is constructed by the interpenetration of a flexible network formed of poly(vinyl alcohol) (PVA) physical cross-linked by repeated freeze-thawing and a rigid network of iron-chelated xanthan gum (XG) impregnated with Fe³⁺ interpenetration. The pure PVA/XG hydrogels were chelated with ferric ions by immersion to improve the gel strength (compressive modulus and tensile modulus can reach up to 0.62 MPa and 0.079 MPa, respectively), conductivity (conductivity values ranging from 9 × 10^-4 S/cm to 1 × 10^-3 S/cm) and bacterial inhibition properties (up to 98.56%). Subsequently, the effects of the ratio of PVA and XG and the immersion time of Fe³⁺ on the hydrogels were investigated, and DNGel3 was given the most priority on a comprehensive consideration. It was demonstrated that the DNCGel exhibit good biocompatibility in vitro, effectively facilitate wound healing in vivo (up to 97.8% healing rate) under electrical stimulation, and monitors human movement in real time. This work provides a novel avenue to explore multifunctional intelligent hydrogels that hold great promise in biomedical fields such as smart wound dressings and flexible wearable sensors.
- Conductive hydrogel,
- Dual cross-linked network,
- Antimicrobial activity,
- Real-time monitorin,
- Wound healing
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