Citation: Zhijun He, Xiaoqian Li, Huajie Zhang, Xin Liu, Shuangxue Han, Anwar Abdurahman, Liming Shen, Xiubo Du, Nan Li, Xiaoda Yang, Qiong Liu. A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide[J]. Chinese Chemical Letters, ;2023, 34(10): 108236. doi: 10.1016/j.cclet.2023.108236 shu

A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide

Zhijun He ^{a, b} ,
Xiaoqian Li ^a ,
Huajie Zhang ^a ,
Xin Liu ^e ,
Shuangxue Han ^a ,
Anwar Abdurahman ^a ,
Liming Shen ^a ,
Xiubo Du ^{a, c} ,
Nan Li ^{a, f, *,} ,
Xiaoda Yang ^{d, *,} ,
Qiong Liu ^{a, c, *,}

a.
Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, China
b.
National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
c.
Shenzhen Bay Laboratory, Shenzhen 518055, China
d.
State Key Laboratories of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
e.
Department of Pharmacy, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China
f.
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China

lin@szu.edu.cn

xyang@bjmu.edu.cn

liuqiong@szu.edu.cn

Received Date: 14 November 2022
Revised Date: 11 February 2023
Accepted Date: 15 February 2023
Available Online: 17 February 2023

Figures(4)

Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of nerve injury. In this paper, a novel vanadium complex, vanadyl N-(p-N,N-dimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)), was synthesized from vanadyl sulfate and N,N-dimethyl-p-phenylenediamine, which was structurally characterized by Fourier transform infrared spectrum and ESI-MS analysis. The effect of VO(p-dmada) on neuroinflammation was investigated by using the models of lipopolysaccharide (LPS)-induced BV2 microglial cells and BALB/c mice. Our data demonstrated that VO(p-dmada) significantly suppressed microglial activation by downregulating inflammatory mediators and associated proteins, and inactivating nuclear factor-κB (NF-κB) signaling pathway. VO(p-dmada) also upregulated peroxisome proliferator activated receptor gamma (PPARγ) by reducing transglutaminase 2 and heat shock protein 60 expression. Co-treatment with PPARγ antagonist GW9662 significantly impeded the inhibitory effect of VO(p-dmada) on LPS-induced neuroinflammation. These cumulative findings demonstrated that VO(p-dmada) is a potential new drug for the treatment of neuroinflammation-related neurodegenerative diseases.
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