Citation: Xueli Zhu, Shengmin Zhang, Yi Cao, Xiaojiao Ge, Yi Huang, Feng Mao, Bo Chen, Juan Li, Youfeng Xu, Aiguo Wu. Black phosphorus nanosheets-based tumor microenvironment responsive multifunctional nanosystem for highly efficient photo-/sono-synergistic therapy of non-Hodgkin lymphoma[J]. Chinese Chemical Letters, ;2023, 34(10): 108234. doi: 10.1016/j.cclet.2023.108234 shu

Black phosphorus nanosheets-based tumor microenvironment responsive multifunctional nanosystem for highly efficient photo-/sono-synergistic therapy of non-Hodgkin lymphoma

Xueli Zhu ^{a, 1} ,
Shengmin Zhang ^{a, 1} ,
Yi Cao ^{b, c} ,
Xiaojiao Ge ^b ,
Yi Huang ^a ,
Feng Mao ^a ,
Bo Chen ^b ,
Juan Li ^{b, *,} ,
Youfeng Xu ^{a, *,} ,
Aiguo Wu ^{b, *,}

a.
Department of Ultrasound, Central Laboratory, Ningbo First Hospital, Ningbo 315000, China;
b.
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, China;
c.
University of Chinese Academy of Sciences, Beijing 100049, China

lij@nimte.ac.cn

xuyoufeng2017@163.com

aiguo@nimte.ac.cn

^†

Received Date: 12 November 2022
Revised Date: 14 February 2023
Accepted Date: 15 February 2023
Available Online: 18 February 2023

Figures(5)

Finding improved therapeutic protocols against non-Hodgkin's lymphoma (NHL) remains an unmet clinical demand. Phototherapy is a promising alternative treatment for traditional clinical therapeutic methods, but the limited tissue penetration blocks the therapeutics. Inspired by the excellent physical and chemical properties of black phosphorus nanosheets (BPNSs), a fluorescence and thermal imaging guided photo-/sono-synergistic treatment platform BPNSs@PEG-SS-IR780/RGD is developed. This ingenious multifunctional theranostic platform not only exhibits outstanding photothermal conversion efficiency and highly efficient reactive oxygen species generation, but also has good biocompatibility, tumor-targeting and tumor microenvironment responsiveness. In addition, BPNSs@PEG-SS-IR780/RGD could actively target the tumor sites and generate excellent photothermal, photodynamic and sonodynamic therapeutic efficacy. Both in vitro and in vivo experiments indicate that BPNSs@PEG-SS-IR780/RGD can be a promising nanomaterial for NHL imaging and therapy. Taken together, this study not only expands the application field of black phosphorus materials, but also provides a possibility to design a new generation of NHL treatment regimens with clinical application potential.
- Non-Hodgkin's lymphoma,
- Black phosphorus,
- IR780,
- Phototherapy,
- Sonodynamic therapy
1. [1]
  J.O. Armitage, R.D. Gascoyne, M.A. Lunning, F. Cavalli, The Lancet 390(2017) 298-310. doi: 10.1016/S0140-6736(16)32407-2
2. [2]
  R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA Cancer J. Clin. 71(2021) 7-33. doi: 10.3322/caac.21654
3. [3]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71(2021) 209-249. doi: 10.3322/caac.21660
4. [4]
  A. Bowzyk Al-Naeeb, T. Ajithkumar, S. Behan, D.J. Hodson, BMJ 362(2018) k3204.
5. [5]
  K.M. Au, A. Tripathy, C.P. Lin, et al., ACS. Nano 12(2018) 1544-1563. doi: 10.1021/acsnano.7b08122
6. [6]
  S. Son, J.H. Kim, X. Wang, et al., Chem. Soc. Rev. 49(2020) 3244-3261. doi: 10.1039/C9CS00648F
7. [7]
  X. Lin, J. Song, X. Chen, H. Yang, Angew. Chem. Int. Ed. 59(2020) 14212-14233. doi: 10.1002/anie.201906823
8. [8]
  W. Yue, L. Chen, L. Yu, et al., Nat. Commun. 10(2019) 2025. doi: 10.1038/s41467-019-09760-3
9. [9]
  X. Pan, W. Wang, Z. Huang, et al., Angew. Chem. Int. Ed. 59(2020) 13557-13561. doi: 10.1002/anie.202004894
10. [10]
  Z. Gong, Z. Dai, Adv. Sci. (Weinh) 8(2021) 2002178. doi: 10.1002/advs.202002178
11. [11]
  S. Liang, X. Deng, P. Ma, Z. Cheng, J. Lin, Adv. Mater. 32(2020) e2003214. doi: 10.1002/adma.202003214
12. [12]
  M. Qiu, W.X. Ren, T. Jeong, et al., Chem. Soc. Rev. 47(2018) 5588-5601. doi: 10.1039/C8CS00342D
13. [13]
  W. Chen, J. Ouyang, X. Yi, et al., Adv. Mater. 30(2018) e1703458. doi: 10.1002/adma.201703458
14. [14]
  S. Anju, J. Ashtami, P.V. Mohanan, Mater. Sci. Eng. C: Mater. Biol Appl. 97(2019) 978-993. doi: 10.1016/j.msec.2018.12.146
15. [15]
  X. Liang, X. Ye, C. Wang, et al., J. Control. Release 296(2019) 150-161. doi: 10.1016/j.jconrel.2019.01.027
16. [16]
  B. Li, C. Lai, G. Zeng, et al., Small 15(2019) e1804565. doi: 10.1002/smll.201804565
17. [17]
  J. Liu, P. Du, T. Liu, et al., Biomaterials 192(2019) 179-188. doi: 10.1016/j.biomaterials.2018.10.018
18. [18]
  Z. Li, T. Zhang, F. Fan, et al., J. Phys. Chem. Lett. 11(2020) 1228-1238. doi: 10.1021/acs.jpclett.9b03769
19. [19]
  T. Chen, W. Zeng, C. Tie, et al., Bioact. Mater. 10(2022) 515-525. doi: 10.1016/j.bioactmat.2021.09.016
20. [20]
  X. Yang, D. Wang, Y. Shi, et al., ACS. Appl. Mater. Interfaces 10(2018) 12431-12440. doi: 10.1021/acsami.8b00276
21. [21]
  K.R. Gajbhiye, V. Gajbhiye, I.A. Siddiqui, J.M. Gajbhiye, J. Drug Target 27(2019) 111-124. doi: 10.1080/1061186X.2018.1473409
22. [22]
  Z. Shi, Q. Li, L. Mei, Chin. Chem. Lett. 31(2020) 1345-1356. doi: 10.1016/j.cclet.2020.03.001
23. [23]
  M. Ou, C. Lin, Y. Wang, et al., J. Control. Release 345(2022) 755-769. doi: 10.1016/j.jconrel.2022.03.059
24. [24]
  X. Zeng, M. Luo, G. Liu, et al., Adv. Sci. (Weinh) 5(2018) 1800510. doi: 10.1002/advs.201800510
25. [25]
  J.N. Coleman, M. Lotya, A. O’Neill, et al., Science 331(2011) 568-571. doi: 10.1126/science.1194975
26. [26]
  J. Huang, B. He, Z. Zhang, et al., Adv. Mater. 32(2020) e2003382. doi: 10.1002/adma.202003382
1. [1]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
2. [2]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
3. [3]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
4. [4]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
5. [5]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
6. [6]
  Yuhao Ma , Yufei Zhou , Mingchuan Yu , Cheng Fang , Shaoxia Yang , Junfeng Niu . Covalently bonded ternary photocatalyst comprising MoSe₂/black phosphorus nanosheet/graphitic carbon nitride for efficient moxifloxacin degradation. Chinese Chemical Letters, 2024, 35(9): 109453-. doi: 10.1016/j.cclet.2023.109453
7. [7]
  Abiduweili Sikandaier , Yukun Zhu , Dongjiang Yang . In-situ decorated cobalt phosphide cocatalyst on Hittorf's phosphorus triggering efficient photocatalytic hydrogen production. Chinese Journal of Structural Chemistry, 2024, 43(2): 100242-100242. doi: 10.1016/j.cjsc.2024.100242
8. [8]
  Wenjuan Jin , Zelong Chen , Yi Wang , Jiaxuan Li , Jiahui Li , Yuxin Pei , Zhichao Pei . Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy. Chinese Chemical Letters, 2024, 35(7): 109328-. doi: 10.1016/j.cclet.2023.109328
9. [9]
  Ling Yang , Min Ren , Jie Wang , Liming He , Shanshan Wu , Shuai Yang , Wei Zhao , Hao Cheng , Xiaoming Zhou , Maling Gou . A non-viral gene therapy for melanoma by staphylococcal enterotoxin A. Chinese Chemical Letters, 2024, 35(5): 108822-. doi: 10.1016/j.cclet.2023.108822
10. [10]
  Chunxiu Yu , Zelin Wu , Hongle Shi , Lingyun Gu , Kexin Chen , Chuan-Shu He , Yang Liu , Heng Zhang , Peng Zhou , Zhaokun Xiong , Bo Lai . Insights into the electron transfer mechanisms of peroxydisulfate activation by modified metal-free acetylene black for degradation of sulfisoxazole. Chinese Chemical Letters, 2024, 35(8): 109334-. doi: 10.1016/j.cclet.2023.109334
11. [11]
  Mei-Chen Liu , Qing-Song Liu , Yi-Zhou Quan , Jia-Ling Yu , Gang Wu , Xiu-Li Wang , Yu-Zhong Wang . Phosphorus-silicon-integrated electrolyte additive boosts cycling performance and safety of high-voltage lithium-ion batteries. Chinese Chemical Letters, 2024, 35(8): 109123-. doi: 10.1016/j.cclet.2023.109123
12. [12]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
13. [13]
  Shiqi Peng , Yongfang Rao , Tan Li , Yufei Zhang , Jun-ji Cao , Shuncheng Lee , Yu Huang . Regulating the electronic structure of Ir single atoms by ZrO₂ nanoparticles for enhanced catalytic oxidation of formaldehyde at room temperature. Chinese Chemical Letters, 2024, 35(7): 109219-. doi: 10.1016/j.cclet.2023.109219
14. [14]
  A-Yang Wang , Sheng-Hua Zhou , Mao-Yin Ran , Xin-Tao Wu , Hua Lin , Qi-Long Zhu . Regulating the key performance parameters for Hg-based IR NLO chalcogenides via bandgap engineering strategy. Chinese Chemical Letters, 2024, 35(10): 109377-. doi: 10.1016/j.cclet.2023.109377
15. [15]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
16. [16]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
17. [17]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
18. [18]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
19. [19]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
20. [20]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(188)
HTML views(5)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142