Citation: Keliang Li, Shanchao Wu, Gaopan Dong, Yu Li, Wei Wang, Guoqiang Dong, Zhanying Hong, Minyong Li, Chunquan Sheng. Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices[J]. Chinese Chemical Letters, ;2023, 34(11): 108231. doi: 10.1016/j.cclet.2023.108231 shu

Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices

Keliang Li ^{a, 1} ,
Shanchao Wu ^{a, 1} ,
Gaopan Dong ^{b, 1} ,
Yu Li ^a ,
Wei Wang ^a ,
Guoqiang Dong ^a ,
Zhanying Hong ^{a, *,} ,
Minyong Li ^{b, *,} ,
Chunquan Sheng ^{a, *,}

a.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
b.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji’nan 250012, China

hongzhy001@163.com

mli@sdu.edu.cn

shengcq@smmu.edu.cn

Received Date: 6 December 2022
Revised Date: 4 February 2023
Accepted Date: 13 February 2023
Available Online: 16 February 2023

Figures(4)

Kirsten rat sarcoma viral oncogene homolog (KRAS)–phosphodiesterase-delta (PDEδ) is a promising target for antitumor drug discovery. Herein, highly efficient and environmentally sensitive fluorescent probes of PDEδ (DS-Probes) were rationally designed. As compared with the reported PDEδ probes, DS-Probes showed higher binding affinity and selectivity, which were able to conveniently and efficiently label PDEδ in live cells as well as tumor tissues. Therefore, these fluorescent probes are expected to facilitate PDEδ-based mechanism elucidation, drug discovery and pathologic diagnosis.
- Antitumor,
- PDEδ,
- Fluorescent probes,
- Environmentally sensitive,
- Binding affinity
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