Citation: Chujing Ye, Shan Zhang, Dongxiang Zhang, Yue Shen, Zhan Wang, Huan Wang, Junyi Ren, Xin-Dong Jiang, Jianjun Du, Rong Shang, Guiling Wang. Engineering J-aggregates for NIR-induced meso-CF₃-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy[J]. Chinese Chemical Letters, ;2023, 34(9): 108223. doi: 10.1016/j.cclet.2023.108223 shu

Engineering J-aggregates for NIR-induced meso-CF₃-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy

Chujing Ye ^{a, 1} ,
Shan Zhang ^{b, 1} ,
Dongxiang Zhang ^{a, 1} ,
Yue Shen ^a ,
Zhan Wang ^b ,
Huan Wang ^b ,
Junyi Ren ^b ,
Xin-Dong Jiang ^a, ,
Jianjun Du ^{c, *,} ,
Rong Shang ^d ,
Guiling Wang ^{b, *,}

a.
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang 110142, China
b.
Department of Cell Biology, China Medical University, Shenyang 110122, China
c.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 110624, China
d.
Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 7398526, Japan

xdjiang@syuct.edu.cn

dujj@dlut.edu.cn

glingwang@cmu.edu.cn

Received Date: 27 November 2022
Revised Date: 6 February 2023
Accepted Date: 10 February 2023
Available Online: 15 February 2023

Figures(5)

Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer. Herein, we designed 1,7-diphenyl-substituted meso–CF₃-BDP monomer confirmed by X-ray crystallographic analysis. The low-barrier rotation of the –CF₃ group in meso–CF₃-BDP 1 significantly enhances the non-radiative efficiency, and the photothermal conversion efficiency (PCE) of the self-assembled nanoparticles (1-NPs: λ_abs = 746 nm) by J-aggregates was 82%. 1-NPs could effectively block cell cycle progression, inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation (0.2 W/cm²). This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.
- NIR dye,
- J-aggregate,
- CF₃-BODIPY,
- Photothermal therapy,
- Cell apoptosis
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Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy

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Engineering J-aggregates for NIR-induced meso-CF₃-BODIPY nanoparticles by activated apoptosis mechanism in photothermal therapy