Citation: Wenyan Yu, Enpeng Gong, Bingbing Liu, Lei Zhou, Chengyuan Che, Shu Hu, Zhenzhong Zhang, Junjie Liu, Jinjin Shi. Hydrogel-mediated drug delivery for treating stroke[J]. Chinese Chemical Letters, ;2023, 34(9): 108205. doi: 10.1016/j.cclet.2023.108205 shu

Hydrogel-mediated drug delivery for treating stroke

Wenyan Yu ^{a, b, c} ,
Enpeng Gong ^a ,
Bingbing Liu ^a ,
Lei Zhou ^a ,
Chengyuan Che ^a ,
Shu Hu ^a ,
Zhenzhong Zhang ^{a, b, c, *,} ,
Junjie Liu ^{a, b, c, *,} ,
Jinjin Shi ^{a, b, c, *,}

a.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
b.
Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China
c.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China

zzuzhangzhenzhong@163.com

liujunjie@zzu.edu.cn

shijinyxy@zzu.edu.cn

Received Date: 17 November 2022
Revised Date: 2 February 2023
Accepted Date: 8 February 2023
Available Online: 10 February 2023

Figures(7)

Stroke is a common disease and is the major cause of death and disability. It occurs and generates devastating neurological deficits when cerebral blood vessel is blocked (ischemic stroke, IS) or ruptured (hemorrhagic stroke, HS). Hydrogel, being biodegradable and biocompatible, have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure, owing to special ability to load different cargoes for multiple treatment strategies, such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs) for improving functional outcomes. However, a comprehensive review of the functional hydrogel for treatment of stroke is still lacking. Therefore, in this work, the main pathological mechanisms of stroke including IS and HS are comprehensively described. The benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery advantages. Simultaneously, the application development of hydrogel for treatment of stroke is highlighted. Finally, the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future.
- Drug delivery,
- Functional hydrogel,
- Stroke therapy,
- Bioactive biomaterials,
- Biological applications
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