Citation: Xin Jin, Qin Wang, Jiezhou Pan, Jin Wang, Yunxiang He, Jiaojiao Shang, Mei Chen, Xianglian He, Yaoyao Zhang, Bo Wang, Yajie Wang, Guidong Gong, Junling Guo. A biologically stable, self-catalytic DNAzyme machine encapsulated by metal-phenolic nanoshells for multiple microRNA imaging[J]. Chinese Chemical Letters, ;2023, 34(10): 108200. doi: 10.1016/j.cclet.2023.108200 shu

A biologically stable, self-catalytic DNAzyme machine encapsulated by metal-phenolic nanoshells for multiple microRNA imaging

Xin Jin ^{a, 1} ,
Qin Wang ^{a, b, 1} ,
Jiezhou Pan ^a ,
Jin Wang ^a ,
Yunxiang He ^{a, e} ,
Jiaojiao Shang ^{a, e} ,
Mei Chen ^a ,
Xianglian He ^a ,
Yaoyao Zhang ^f ,
Bo Wang ^g ,
Yajie Wang ^h ,
Guidong Gong ^{a, e, *,} ,
Junling Guo ^{a, c, d, e, *,}

a.
BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China
b.
School of Pharmacy, Southwest Minzu University, Chengdu 610225, China
c.
Department of Chemical and Biological Engineering, Bioproducts Institute, University of British Columbia, Vancouver BC V6T 1Z4, Canada
d.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
e.
National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China
f.
Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, The Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu 610041, China
g.
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
h.
School of Engineering, Westlake University, Hangzhou 310034, China

guidong-gong@qq.com

junling.guo@scu.edu.cn

Received Date: 20 September 2022
Revised Date: 3 February 2023
Accepted Date: 8 February 2023
Available Online: 16 February 2023

Figures(3)

DNAzyme machines play critical roles in the fields of cell imaging, disease diagnosis, and cancer therapy. However, the applications of DNAzyme machines are limited by the nucleases-induced degradation, non-specific binding of proteins, and insufficient provision of cofactors. Herein, protected DNAzyme machines with different cofactor designs (referred to as ProDs) were nanoengineered by the construction of multifunctional metal-phenolic nanoshells to deactivate the interferential proteins, including nucleases and non-specific binding proteins. Moreover, the nanoshells not only facilitate the cellular internalization of ProDs but provide specific metal ions acting as cofactors of the designed DNAzymes. Cellular imaging results demonstrated that ProDs could effectively and simultaneously monitor multiple tumor-related microRNAs in living cells. This facile and rapid strategy that encapsulates DNAzyme machines into the protective metal-phenolic nanoshells is anticipated to extend to a wide range of functional nucleic acids-based biomedical applications.
- DNAzyme machine,
- Metal-phenolic nanoshells,
- Interference protection,
- Cofactors self-supply,
- Cell imaging
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