Citation: Shengtao Wang, Kunyi Yu, Zhiyu Yu, Bingchen Zhang, Chaojie Chen, Ling Lin, Zibo Li, Zhongjun Li, Yuhua Zheng, Zhiqiang Yu. Targeting self-enhanced ROS-responsive artesunatum prodrug nanoassembly potentiates gemcitabine activity by down-regulating CDA expression in cervical cancer[J]. Chinese Chemical Letters, ;2023, 34(7): 108184. doi: 10.1016/j.cclet.2023.108184 shu

Targeting self-enhanced ROS-responsive artesunatum prodrug nanoassembly potentiates gemcitabine activity by down-regulating CDA expression in cervical cancer

Shengtao Wang ^{a, b, 1} ,
Kunyi Yu ^{b, 1} ,
Zhiyu Yu ^{b, 1} ,
Bingchen Zhang ^{b, c} ,
Chaojie Chen ^b ,
Ling Lin ^b ,
Zibo Li ^b ,
Zhongjun Li ^{c, *,} ,
Yuhua Zheng ^{a, **,} ,
Zhiqiang Yu ^{b, c, *,}

a.
Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China
b.
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
c.
Department of Obstetrics and Gynecology, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523059, China

^**

Zhongjun@gdmu.edu.cn

zyh2013916@163.com

yuzq@smu.edu.cn

Received Date: 24 November 2022
Revised Date: 25 December 2022
Accepted Date: 31 January 2023
Available Online: 7 February 2023

Figures(4)

Prodrug self-delivery carriers with targeting that specifically responded to tumor microenvironments have good potential to improve the application dilemma of approved clinical therapeutic drugs (systemic distribution and side effects). It's noted the conversion of gemcitabine (GEM) to inactive ingredients under the action of cytidine deaminase (CDA) during metabolism in vivo limits its clinical effect. A high level of reactive oxygen species (ROS) results in a high level of oxidative stress in tumor cells, which changes the expression of CDA and optimizes the metabolism of GEM in vivo and overcome drug resistance. In this study, the ROS responsive and ROS self-supplied prodrug of artemisia (ART)-thioacetal bond (TK)-GEM was synthesized and self-vectors based on ART-TK-GEM (TK@FA NPs) was prepared by using nano precipitation. ROS responsive characteristics ensure specific release of prodrugs in tumor cells with high level of ROS thereby reducing side effects on normal cells and tissues. The endogenous ROS and newly generated ROS by ART can reduce the expression of CDA and optimizes the metabolism of GEM, and the accumulated ROS can also induce apoptosis of tumor cells, realizing synergistic anti-tumor effect of chemical drugs and traditional Chinese medicines. This paper proposes a simple method by using clinically approved drugs to improve the insufficient effect of existing chemotherapy and overcome resistance, which has potential to appropriately shorten the drug development cycle and accelerate the clinical investigation of drugs.
- ROS self-supplied,
- ROS-responsive,
- Self-delivery carrier,
- Down regulation of CDA,
- Synergistic anti-tumor effect,
- Cervical cancer
1. [1]
  J. Ouyang, A. Xie, J. Zhou, et al., Chem. Soc. Rev. 51 (2022) 4996–5041. doi: 10.1039/D1CS01148K
2. [2]
  X. Shan, X. Gong, J. Lia, et al., Acta Pharm. Sin. B 12 (2022) 3028–3048. doi: 10.1016/j.apsb.2022.02.025
3. [3]
  D.Y. Hou, M.D. Wang, N.Y. Zhang, et al., Nano Lett. 22 (2022) 3983–3992. doi: 10.1021/acs.nanolett.2c00540
4. [4]
  S. Wang, J. Li, Z. Ye, et al., Colloids Surf. A 574 (2019) 44–51. doi: 10.1016/j.colsurfa.2019.04.060
5. [5]
  Z. Li, Q. Xu, X. Lin, et al., Chin. Chem. Lett. 33 (2022) 1875–1879. doi: 10.1016/j.cclet.2021.10.077
6. [6]
  Y.C. Zhang, L. She, Z.Y. Xu, et al., Chin. Chem. Lett. 33 (2022) 3277–3280. doi: 10.1016/j.cclet.2021.11.004
7. [7]
  L.H. Liu, X.Z. Zhang, Prog. Mater. Sci. 125 (2022) 100919. doi: 10.1016/j.pmatsci.2021.100919
8. [8]
  S. Karaosmanoglu, M. Zhou, B. Shi, et al., J. Control. Release 329 (2021) 805–832. doi: 10.1016/j.jconrel.2020.10.014
9. [9]
  R. Liu, C. Luo, Z. Pang, et al., Chin. Chem. Lett. 34 (2023) 107518. doi: 10.1016/j.cclet.2022.05.032
10. [10]
  Y. Yang, S. Zuo, J. Zhang, et al., Nano Today 44 (2022) 101480. doi: 10.1016/j.nantod.2022.101480
11. [11]
  Q. Wang, C. Wang, S. Li, et al., Chem. Mater. 34 (2022) 2085–2097. doi: 10.1021/acs.chemmater.1c03346
12. [12]
  A. Çapcı, L. Herrmann, H.M.S. Kumar, T. Fröhlich, S.B. Tsogoeva, Med. Res. Rev. 41 (2021) 2927–2970. doi: 10.1002/med.21814
13. [13]
  X. Dong, R.K. Brahma, C. Fang, S.Q. Yao, Chem. Sci. 13 (2022) 4239–4269. doi: 10.1039/D2SC01003H
14. [14]
  Y. Zhang, H. Cui, R. Zhang, H. Zhang, W. Huang, Adv. Sci. 8 (2021) 2101454. doi: 10.1002/advs.202101454
15. [15]
  J. Xiang, X. Liu, G. Yuan, et al., Adv. Drug Deliv. Rev. 179 (2021) 114027. doi: 10.1016/j.addr.2021.114027
16. [16]
  D.H. Zhao, C.Q. Li, X.L. Hou, et al., ACS Appl. Mater. Interfaces 13 (2021) 55780–55789. doi: 10.1021/acsami.1c12611
17. [17]
  S. Wang, Z. Zhao, J. Yao, et al., Chin. Chem. Lett. 34 (2023) 107805. doi: 10.1016/j.cclet.2022.107805
18. [18]
  M. Scaranti, E. Cojocaru, S. Banerjee, U. Banerji, Nat. Rev. Clin. Oncol. 17 (2020) 349–359. doi: 10.1038/s41571-020-0339-5
19. [19]
  Y. Zhua, J. Feijena, Z. Zhong, Nano Today 18 (2018) 65–85. doi: 10.1016/j.nantod.2017.12.007
20. [20]
  R. Zhao, B. Wang, X. Yang, et al., Angew. Chem. Int. Ed. 55 (2016) 5225–5229. doi: 10.1002/anie.201601364
21. [21]
  M. Wang, Z. Guo, J. Zeng, et al., Chin. Chem. Lett. 34 (2023) 107651. doi: 10.1016/j.cclet.2022.06.074
22. [22]
  F.G. Ye, C.G. Song, Z.G. Cao, et al., Cancer Res. 75 (2015) 1504–1515. doi: 10.1158/0008-5472.CAN-14-2341
23. [23]
  E. Moysan, G. Bastiat, J.P. Benoit, Mol. Pharm. 10 (2013) 430–444. doi: 10.1021/mp300370t
24. [24]
  H. Meng, M. Wang, H. Liu, et al., ACS Nano 8 (2015) 3540–3557. doi: 10.1021/acsnano.6b03110
25. [25]
  K.K. Frese, A. Neesse, N. Cook, et al., Cancer Discov. 2 (2012) 260–269. doi: 10.1158/2159-8290.CD-11-0242
26. [26]
  I.M. Ahmad, A.J. Dafferner, K.A. O'Connell, et al., Cancers 13 (2021) 2264 Basel. doi: 10.3390/cancers13092264
27. [27]
  H. Sun, L. Yan, R. Zhang, et al., Biomater. Sci. 9 (2021) 5000–5010. doi: 10.1039/D1BM00393C
28. [28]
  S. Yang, D. Zhang, N. Shen, et al., J. Cell. Biochem. 120 (2019) 634–644. doi: 10.1002/jcb.27421
29. [29]
  S. Wang, A. Wang, Y. Ma, et al., Biomater. Sci. 9 (2021) 774–779. doi: 10.1039/D0BM01618G
30. [30]
  L. Yu, Z. Wang, Z. Mo, et al., Acta Pharm. Sin. B 11 (2021) 2004–2015. doi: 10.1016/j.apsb.2021.02.001
31. [31]
  H. Li, Y. Chen, T. Chen, et al., NPG Asia Mater. 9 (2017) e423. doi: 10.1038/am.2017.150
32. [32]
  L. Huang, Y. Luo, X. Sun, et al., Biosens. Bioelectron. 92 (2017) 724–732. doi: 10.1016/j.bios.2016.10.004
33. [33]
  T. Efferth, Semin. Cancer Biol. 46 (2017) 65–83. doi: 10.1016/j.semcancer.2017.02.009
34. [34]
  Q. Li, Q. Ma, J. Cheng, et al., OncoTargets Ther. 14 (2021) 2563–2573. doi: 10.2147/OTT.S297785
35. [35]
  T. Efferth, Biochem. Pharmacol. 139 (2017) 56–70. doi: 10.1016/j.bcp.2017.03.019
36. [36]
  G. Ren, D. Duan, G. Wang, et al., Colloids Surf. B 217 (2022) 112614. doi: 10.1016/j.colsurfb.2022.112614
37. [37]
  Y. Hao, Y. Chen, X. He, et al., Adv. Sci. 7 (2020) 2001853. doi: 10.1002/advs.202001853
38. [38]
  M. Jiang, J. Mu, O. Jacobson, et al., ACS Nano 14 (2020) 16875–16886. doi: 10.1021/acsnano.0c05722
39. [39]
  S. Dalin, M.R. Sullivan, A.N. Lau, et al., Cancer Res. 79 (2019) 5723–5733. doi: 10.1158/0008-5472.CAN-19-0960
1. [1]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
2. [2]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
3. [3]
  Luyu Zhang , Zirong Dong , Shuai Yu , Guangyue Li , Weiwen Kong , Wenjuan Liu , Haisheng He , Yi Lu , Wei Wu , Jianping Qi . Ionic liquid-based in situ dynamically self-assembled cationic lipid nanocomplexes (CLNs) for enhanced intranasal siRNA delivery. Chinese Chemical Letters, 2024, 35(7): 109101-. doi: 10.1016/j.cclet.2023.109101
4. [4]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
5. [5]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
6. [6]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
7. [7]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
8. [8]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
9. [9]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
10. [10]
  Changzhu Huang , Wei Dai , Shimao Deng , Yixin Tian , Xiaolin Liu , Jia Lin , Hong Chen . A self-cleaning window for high-efficiency photodegradation of indoor formaldehyde. Chinese Chemical Letters, 2024, 35(9): 109429-. doi: 10.1016/j.cclet.2023.109429
11. [11]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
12. [12]
  Jingqi Xin , Shupeng Han , Meichen Zheng , Chenfeng Xu , Zhongxi Huang , Bin Wang , Changmin Yu , Feifei An , Yu Ren . A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance. Chinese Chemical Letters, 2024, 35(7): 109165-. doi: 10.1016/j.cclet.2023.109165
13. [13]
  Zhenzhu Wang , Chenglong Liu , Yunpeng Ge , Wencan Li , Chenyang Zhang , Bing Yang , Shizhong Mao , Zeyuan Dong . Differentiated self-assembly through orthogonal noncovalent interactions towards the synthesis of two-dimensional woven supramolecular polymers. Chinese Chemical Letters, 2024, 35(5): 109127-. doi: 10.1016/j.cclet.2023.109127
14. [14]
  Supphachok Chanmungkalakul , Syed Ali Abbas Abedi , Federico J. Hernández , Jianwei Xu , Xiaogang Liu . The dark side of cyclooctatetraene (COT): Photophysics in the singlet states of “self-healing” dyes. Chinese Chemical Letters, 2024, 35(8): 109227-. doi: 10.1016/j.cclet.2023.109227
15. [15]
  Chunqing Ou , Meijia Xiao , Xinyue Zheng , Xianzhou Huang , Suleixin Yang , Yingying Leng , Xiaowei Liu , Xiuqi Liang , Linjiang Song , Yanjie You , Shaohua Yao , Changyang Gong . Programmable double-unlock nanocomplex self-supplies phenylalanine ammonia-lyase for precise phenylalanine deprivation of tumors. Chinese Chemical Letters, 2024, 35(8): 109275-. doi: 10.1016/j.cclet.2023.109275
16. [16]
  Sifan Du , Yuan Wang , Fulin Wang , Tianyu Wang , Li Zhang , Minghua Liu . Evolution of hollow nanosphere to microtube in the self-assembly of chiral dansyl derivatives and inversed circularly polarized luminescence. Chinese Chemical Letters, 2024, 35(7): 109256-. doi: 10.1016/j.cclet.2023.109256
17. [17]
  Caixia Li , Yi Qiu , Yufeng Zhao , Wuliang Feng . Self assembled electron blocking and lithiophilic interface towards dendrite-free solid-state lithium battery. Chinese Chemical Letters, 2024, 35(4): 108846-. doi: 10.1016/j.cclet.2023.108846
18. [18]
  Xingwen Cheng , Haoran Ren , Jiangshan Luo . Boosting the self-trapped exciton emission in vacancy-ordered double perovskites via supramolecular assembly. Chinese Journal of Structural Chemistry, 2024, 43(6): 100306-100306. doi: 10.1016/j.cjsc.2024.100306
19. [19]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
20. [20]
  Wen Xiao , Fazhan Wang , Yangzhuo Gu , Xi He , Na Fan , Qian Zheng , Shugang Qin , Zhongshan He , Yuquan Wei , Xiangrong Song . PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines. Chinese Chemical Letters, 2024, 35(5): 108755-. doi: 10.1016/j.cclet.2023.108755

Get Citation

PDF

XML

Metrics

PDF Downloads(9)
Abstract views(480)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142