Citation: Haining Zhang, Chaojun He, Limin Shen, Wenjun Tao, Jianhui Zhu, Jinzhao Song, Ziyong Li, Jun Yin. Membrane-targeting amphiphilic AIE photosensitizer for broad-spectrum bacteria imaging and photodynamic killing of bacteria[J]. Chinese Chemical Letters, ;2023, 34(9): 108160. doi: 10.1016/j.cclet.2023.108160 shu

Membrane-targeting amphiphilic AIE photosensitizer for broad-spectrum bacteria imaging and photodynamic killing of bacteria

Haining Zhang ^a ,
Chaojun He ^a ,
Limin Shen ^a ,
Wenjun Tao ^b ,
Jianhui Zhu ^a ,
Jinzhao Song ^a ,
Ziyong Li ^{a, *,} ,
Jun Yin ^{b, *,}

a.
Luoyang Key Laboratory of Organic Functional Molecules, College of Food and Drug, Luoyang Normal University, Luoyang 471934, China
b.
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China

liziyong@mails.ccnu.edu.cn

yinj@mail.ccnu.edu.cn

Received Date: 10 November 2022
Revised Date: 19 January 2023
Accepted Date: 26 January 2023
Available Online: 27 January 2023

Figures(4)

An amphiphilic AIE photosensitizer has been successfully developed, which allows for easily inserting into the bacterial membranes. Binding experiments with phospholipid preliminary demonstrates its membrane specificity. As expected, it is proved to possess a broad-spectrum bacterial staining performance and photodynamic antibacterial activity toward S. aureus and E. coli.
- Photodynamic therapy,
- Aggregation-induced emission,
- Photosensitizer,
- Membrane-targeting,
- Singlet oxygen,
- Broad-spectrum,
- Bacteria imaging
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