Citation: Wanqiong Huang, Chen Pan, Yongliang Huang, Tao Huang, Xiaonan Dong, Yunzhou Chen, Huatian Shi, Taichu Lau, Wailun Man, Wenxiu Ni. (Salen)osmium(Ⅵ) nitrides catalyzed glutathione depletion in chemotherapy[J]. Chinese Chemical Letters, ;2023, 34(10): 108153. doi: 10.1016/j.cclet.2023.108153 shu

(Salen)osmium(Ⅵ) nitrides catalyzed glutathione depletion in chemotherapy

Wanqiong Huang ^a ,
Chen Pan ^a ,
Yongliang Huang ^a ,
Tao Huang ^a ,
Xiaonan Dong ^a ,
Yunzhou Chen ^b ,
Huatian Shi ^b ,
Taichu Lau ^c ,
Wailun Man ^{b, *,} ,
Wenxiu Ni ^{a, d, **,}

a.
Department of Medicinal Chemistry, Shantou University Medical College, Shantou 515041, China
b.
Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
c.
Department of Chemistry, City University of Hong Kong, Hong Kong, China
d.
Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515063, China

^**

wlman118@hkbu.edu.hk

wxni@stu.edu.cn

Received Date: 6 November 2022
Revised Date: 13 January 2023
Accepted Date: 13 January 2023
Available Online: 15 January 2023

Figures(10)

Glutathione depletion provides a promising strategy for the design of non-platinum anticancer drugs. Here we report a series of electrophilic (salen)osmium(Ⅵ) nitrides that react with glutathione to generate (salen)osmium(Ⅲ) ammine compounds. In vitro studies indicate that these osmium(Ⅵ) nitrides show comparable cytotoxicity to cisplatin against various carcinoma. Mechanistic studies with the representative compound [Os^Ⅵ(N)(L^H)(OH₂)](PF₆) (1, L^H = N,N′-bis(salicylidene)-o-cyclohexyldiamine dianion) suggest that 1 induces glutathione depletion, reactive oxygen species generation, endoplasmic reticulum stress, and in turn triggers death receptor-mediated apoptosis and autophagy in lung cancer cells. In vivo evaluations show that 1 can inhibit tumor xenograft growth effectively with no body weight drop.
- Chemotherapy,
- Osmium complex,
- Glutathione depletion,
- Apoptosis,
- Autophagy
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