Citation: Hang Yang, Yuting Xiong, Minmin Li, Zhiying Yang, Peiran Meng, Guangyan Qing. Self-assembly of phosphorylated peptide driven by Dy³⁺[J]. Chinese Chemical Letters, ;2023, 34(8): 108106. doi: 10.1016/j.cclet.2022.108106 shu

Self-assembly of phosphorylated peptide driven by Dy³⁺

Hang Yang ^{a, b} ,
Yuting Xiong ^a ,
Minmin Li ^a ,
Zhiying Yang ^{a, c} ,
Peiran Meng ^a ,
Guangyan Qing ^{a, *,}

a.
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China

qinggy@dicp.ac.cn

Received Date: 7 September 2022
Revised Date: 18 December 2022
Accepted Date: 25 December 2022
Available Online: 27 December 2022

Figures(4)

Nature chooses phosphorylation as a key modification to modulate and program the functions of proteins. Various phosphorylated peptides (PPs) have been widely identified and investigated by biologists, but the possibility that PPs could become a building unit for artificial materials is neglected. Here we report for the first time a supramolecular assembly of PPs with the assistance of dysprosium ions (Dy³⁺). Dy³⁺ bridges multiple phosphate groups in double-phosphorylated peptides (di-PPs), and braid these peptide chains into nanofibers. The assembly occurs inside nanochannels and blocks the channels, leading to prominent "ON–OFF" switching in transmembrane ionic current. The di-PPs' assembling process could be dynamically regulated by the addition or deletion of phosphate groups under the control of kinases or phosphatases. This study proves the huge potential of PPs being utilized as materials via self-assembling, which will promote the design of novel bio-inspired artificial materials and devices.
- Nanochannel,
- Phosphorylation,
- Self-assembly,
- Peptides,
- Dysprosium
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Self-assembly of phosphorylated peptide driven by Dy3+

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通讯作者: 陈斌, bchen63@163.com

Self-assembly of phosphorylated peptide driven by Dy³⁺