Citation: Qihui Wang, Jiayi Luan, Zhilong Zhao, Weihui Kong, Congxiao Zhang, Jianxun Ding. Dentin-desensitizing biomaterials[J]. Chinese Chemical Letters, ;2023, 34(8): 108060. doi: 10.1016/j.cclet.2022.108060 shu

Dentin-desensitizing biomaterials

Qihui Wang ^{a, b} ,
Jiayi Luan ^{b, c} ,
Zhilong Zhao ^a ,
Weihui Kong ^a ,
Congxiao Zhang ^{a, *,} ,
Jianxun Ding ^{b, *,}

a.
Department of Stomatology, the First Hospital of Jilin University, Changchun 130061, China
b.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
c.
VIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

zhangcongxiao@jlu.edu.cn

jxding@ciac.ac.cn

Received Date: 15 October 2022
Revised Date: 10 December 2022
Accepted Date: 12 December 2022
Available Online: 14 December 2022

Figures(3)

Dentin hypersensitivity (DH) associated with dentinal tubule exposure is one of the most common causes of toothache with a rapid onset and short duration. Medication, filling repair, laser irradiation, crown therapy, and desensitizing toothpaste are standard clinical treatment strategies, but unsatisfactory treatment modalities are marked by long-term administration, poor dentinal tubule closure, microleakage, and the development of secondary caries. To improve the treatment efficiency of DH, numerous organic or inorganic biomaterials have been developed to relieve toothache and reverse the instability of desensitization. Biomaterials are expected to participate in dental remineralization to achieve desensitization. This review discusses various biomaterials for DH therapy based on different desensitization mechanisms, including dentinal tubule closure and dental nerve blockade, and presents a perspective on the underlying future of dentin regeneration medicine for DH therapy.
- Biomaterial,
- Dentin hypersensitivity,
- Dentinal tubule closure,
- Dental nerve blockade,
- Regenerative medicine
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