Citation: Dazhi Feng, Lihua Liu, Yuqi Shi, Pian Du, Shengtao Xu, Zheying Zhu, Jinyi Xu, Hong Yao. Current development of bicyclic peptides[J]. Chinese Chemical Letters, ;2023, 34(6): 108026. doi: 10.1016/j.cclet.2022.108026 shu

Current development of bicyclic peptides

Dazhi Feng ^a ,
Lihua Liu ^a ,
Yuqi Shi ^a ,
Pian Du ^a ,
Shengtao Xu ^{a, *,} ,
Zheying Zhu ^b ,
Jinyi Xu ^{a, *,} ,
Hong Yao ^{a, *,}

a.
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
b.
School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, United Kingdom

cpuxst@163.com

jinyixu@china.com

hyao1989@sina.cn

Received Date: 23 August 2022
Revised Date: 22 November 2022
Accepted Date: 28 November 2022
Available Online: 29 November 2022

Figures(18)

Bicyclic peptides, a class of polypeptides with two loops within their structure, have emerged as powerful tools in the development of new peptide drugs. They have the potential to bind to challenged drug targets, with antibody-like affinity and selectivity. Meanwhile, bicyclic peptides possess small molecule-like access to chemical synthesis, which is conducive to large-scale synthesis and screening. In the last five years, bicyclic peptide technology has been increasingly developed, and researchers have carried out a variety of studies to elucidate the potential functions of bicyclic peptides. With the continuous development of synthetic methods and the advances of new technology to build bicyclic peptide libraries, bicyclic peptides are now becoming widely used in the development of new drugs for various diseases. This perspective provides an overview of the structure types, synthesis and applications of bicyclic peptides in current drug development, and our own views on future challenges of bicyclic peptides.
- Peptide therapeutics,
- Bicyclic peptides,
- Protein-protein interaction,
- Peptides synthesis,
- Peptide drugs
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