Citation: Dazhi Feng, Lihua Liu, Yuqi Shi, Pian Du, Shengtao Xu, Zheying Zhu, Jinyi Xu, Hong Yao. Current development of bicyclic peptides[J]. Chinese Chemical Letters, ;2023, 34(6): 108026. doi: 10.1016/j.cclet.2022.108026 shu

Current development of bicyclic peptides

Dazhi Feng ^a ,
Lihua Liu ^a ,
Yuqi Shi ^a ,
Pian Du ^a ,
Shengtao Xu ^{a, *,} ,
Zheying Zhu ^b ,
Jinyi Xu ^{a, *,} ,
Hong Yao ^{a, *,}

a.
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
b.
School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, United Kingdom

cpuxst@163.com

jinyixu@china.com

hyao1989@sina.cn

Received Date: 23 August 2022
Revised Date: 22 November 2022
Accepted Date: 28 November 2022
Available Online: 29 November 2022

Figures(18)

Bicyclic peptides, a class of polypeptides with two loops within their structure, have emerged as powerful tools in the development of new peptide drugs. They have the potential to bind to challenged drug targets, with antibody-like affinity and selectivity. Meanwhile, bicyclic peptides possess small molecule-like access to chemical synthesis, which is conducive to large-scale synthesis and screening. In the last five years, bicyclic peptide technology has been increasingly developed, and researchers have carried out a variety of studies to elucidate the potential functions of bicyclic peptides. With the continuous development of synthetic methods and the advances of new technology to build bicyclic peptide libraries, bicyclic peptides are now becoming widely used in the development of new drugs for various diseases. This perspective provides an overview of the structure types, synthesis and applications of bicyclic peptides in current drug development, and our own views on future challenges of bicyclic peptides.
- Peptide therapeutics,
- Bicyclic peptides,
- Protein-protein interaction,
- Peptides synthesis,
- Peptide drugs
1. [1]
  A. Mullard, Nat. Rev. Drug. Discov. 20 (2021) 85-90. doi: 10.1038/d41573-021-00002-0
2. [2]
  C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney, Adv. Drug. Deliv. Rev. 46 (2001) 3-26.
3. [3]
  J.A. Robinson, S. Demarco, F. Gombert, K. Moehle, D. Obrecht, Drug Discov. Today 13 (2008) 944-951.
4. [4]
  E.V. Gurevich, V.V. Gurevich, Handb. Exp. Pharmacol. 219 (2014) 1-12. doi: 10.1007/978-3-642-41199-1_1
5. [5]
  L.K. Buckton, M.N. Rahimi, S.R. McAlpine, Chem. Eur. J. 27 (2021) 1487-1513. doi: 10.1002/chem.201905385
6. [6]
  P.M. O'Neil, A.L. Birkenfeld, B. McGowan, et al., Lancet 392 (2018) 637-649.
7. [7]
  P.G. Dougherty, A. Sahni, D. Pei, Chem. Rev. 119 (2019) 10241-10287. doi: 10.1021/acs.chemrev.9b00008
8. [8]
  Z. Qian, P.G. Dougherty, D. Pei, Curr. Opin. Chem. Biol. 38 (2017) 80-86.
9. [9]
  F. Giordanetto, J. Kihlberg, J. Med. Chem. 57 (2014) 278-295. doi: 10.1021/jm400887j
10. [10]
  J.E. Bock, J. Gavenonis, J.A. Kritzer, ACS Chem. Biol. 8 (2013) 488-499. doi: 10.1021/cb300515u
11. [11]
  C.A. Rhodes, D. Pei, Chem. Eur. J. 23 (2017) 12690-12703. doi: 10.1002/chem.201702117
12. [12]
  G.M. Watson, K. Kulkarni, J. Sang, et al., J. Med. Chem. 60 (2017) 9349-9359. doi: 10.1021/acs.jmedchem.7b01320
13. [13]
  T. Mund, M.J. Lewis, S. Maslen, H.R. Pelham, Proc. Natl. Acad. Sci. U. S. A. 111 (2014) 16736-16741. doi: 10.1073/pnas.1412152111
14. [14]
  J.S. Quartararo, M.R. Eshelman, L. Peraro, et al., Bioorg. Med. Chem. 22 (2014) 6387-6391.
15. [15]
  M. Wendt, R. Bellavita, A. Gerber, et al., Angew. Chem. Int. Ed. 60 (2021) 13937-13944. doi: 10.1002/anie.202102082
16. [16]
  H. Ueda, T. Manda, S. Matsumoto, et al., J. Antibiot. 47 (1994) 315-323. doi: 10.7164/antibiotics.47.315
17. [17]
  V. Baeriswyl, H. Rapley, L. Pollaro, et al., ChemMedChem 7 (2012) 1173-1176. doi: 10.1002/cmdc.201200071
18. [18]
  D. Bernhagen, V. Jungbluth, N.G. Quilis, et al., ACS Comb. Sci. 21 (2019) 198-206. doi: 10.1021/acscombsci.8b00144
19. [19]
  D.D. Smith, J. Slaninova, V.J. Hruby, J. Med. Chem. 35 (1992) 1558-1563. doi: 10.1021/jm00087a009
20. [20]
  M. Eder, S. Pavan, U. Bauder-Wüst, et al., Cancer Res. 79 (2019) 841-852. doi: 10.1158/0008-5472.can-18-0238
21. [21]
  M. Li, X. Shao, C. Wu, et al., Chem. Commun. 56 (2020) 9537-9540. doi: 10.1039/d0cc01089h
22. [22]
  I. Di Bonaventura, S. Baeriswyl, A. Capecchi, et al., Chem. Commun. 54 (2018) 5130-5133. doi: 10.1039/c8cc02412j
23. [23]
  N.E. Shepherd, R.S. Harrison, G. Ruiz-Gomez, et al., Org. Biomol. Chem. 14 (2016) 10939-10945.
24. [24]
  S. Ahangarzadeh, M.M. Kanafi, S. Hosseinzadeh, et al., Drug Discov. Today 24 (2019) 1311-1319.
25. [25]
  Z. Qian, C.A. Rhodes, L.C. McCroskey, et al., Angew. Chem. Int. Ed. 56 (2017) 1525-1529. doi: 10.1002/anie.201610888
26. [26]
  G. Zanotti, C. Birr, T. Wieland, Int. J. Pept. Protein Res. 12 (1978) 204-216.
27. [27]
  K. Matinkhoo, A. Pryyma, M. Todorovic, B.O. Patrick, D.M. Perrin, J. Am. Chem. Soc. 140 (2018) 6513-6517. doi: 10.1021/jacs.7b12698
28. [28]
  P.E. Dawson, T.W. Muir, I. Clark-Lewis, S.B. Kent, Science 266 (1994) 776-779. doi: 10.1126/science.7973629
29. [29]
  N. Ghalit, J.F. Reichwein, H.W. Hilbers, et al., ChemBioChem 8 (2007) 1540-1554. doi: 10.1002/cbic.200700244
30. [30]
  L. Mendive-Tapia, S. Preciado, J. Garcia, et al., Nat. Commun. 6 (2015) 7160.
31. [31]
  M. Bartoloni, X. Jin, M.J. Marcaida, et al., Chem. Sci. 6 (2015) 5473-5490.
32. [32]
  C. Xu, J. Xu, H. Liu, X. Li, Chin. Chem. Lett. 29 (2018) 1119-1122.
33. [33]
  B.K. Chung, A.K. Yudin, Org. Biomol. Chem. 13 (2015) 8768-8779.
34. [34]
  Y. Wang, B.J. Bruno, S. Cornillie, et al., Chemistry 23 (2017) 7087-7092. doi: 10.1002/chem.201700572
35. [35]
  Y. Yin, Q. Fei, W. Liu, et al., Angew. Chem. Int. Ed. 58 (2019) 4880-4885. doi: 10.1002/anie.201813827
36. [36]
  P. Lin, H. Yao, J. Zha, Y. Zhao, C. Wu, ChemBioChem 20 (2019) 1514-1518. doi: 10.1002/cbic.201800788
37. [37]
  P. Yang, X. Wang, B. Li, et al., Chem. Sci. 12 (2021) 5804-5810. doi: 10.1039/d1sc00789k
38. [38]
  W. Muramatsu, T. Hattori, H. Yamamoto, J. Am. Chem. Soc. 141 (2019) 12288-12295. doi: 10.1021/jacs.9b03850
39. [39]
  Y. Sun, G. Lu, J.P. Tam, Org. Lett. 3 (2001) 1681-1684.
40. [40]
  C.H.P. Cheung, J. Xu, C.L. Lee, et al., Chem. Sci. 12 (2021) 7091-7097. doi: 10.1039/d1sc01174j
41. [41]
  X. Elduque, E. Pedroso, A. Grandas, Org. Lett. 15 (2013) 2038-2041. doi: 10.1021/ol400726y
42. [42]
  P.M. Cromm, S. Schaubach, J. Spiegel, et al., Nat. Commun. 7 (2016) 11300.
43. [43]
  T. Ikenoue, F.A. Aprile, P. Sormanni, et al., Sci. Rep. 10 (2020) 15280.
44. [44]
  J. Zhang, J. Kemmink, D.T. Rijkers, R.M. Liskamp, Chem. Commun. 49 (2013) 4498-4500. doi: 10.1039/c3cc40628h
45. [45]
  W. Lian, P. Upadhyaya, C.A. Rhodes, Y. Liu, D. Pei, J. Am. Chem. Soc. 135 (2013) 11990-11995. doi: 10.1021/ja405106u
46. [46]
  H. vandeLangemheen, V. Korotkovs, J. Bijl, et al., ChemBioChem 18 (2017) 387-395. doi: 10.1002/cbic.201600612
47. [47]
  S. Fodor, J. Read, M. Pirrung, et al., Science 251 (1991) 767-773. doi: 10.1126/science.1990438
48. [48]
  A. Furka, F. Sebestyen, M. Asgedom, G. Dibo, Int. J. Pept. Protein Res. 37 (1991) 487-493.
49. [49]
  K.S. Lam, S.E. Salmon, E.M. Hersh, et al., Nature 354 (1991) 82-84.
50. [50]
  R. Liu, J. Marik, K.S. Lam, J. Am. Chem. Soc. 124 (2002) 7678-7680.
51. [51]
  S.H. Joo, Q. Xiao, Y. Ling, B. Gopishetty, D. Pei, J. Am. Chem. Soc. 128 (2006) 13000-13009. doi: 10.1021/ja063722k
52. [52]
  Z.J. Gartner, B.N. Tse, R. Grubina, et al., Science 305 (2004) 1601-1605.
53. [53]
  C.J. Stress, B. Sauter, L.A. Schneider, T. Sharpe, D. Gillingham, Angew. Chem. Int. Ed. 58 (2019) 9570-9574. doi: 10.1002/anie.201902513
54. [54]
  Z. Zhu, A. Shaginian, L.C. Grady, et al., ACS Chem. Biol. 13 (2018) 53-59. doi: 10.1021/acschembio.7b00852
55. [55]
  Y. Onda, G. Bassi, A. Elsayed, et al., Chemistry 27 (2021) 7160-7167. doi: 10.1002/chem.202005423
56. [56]
  C. Heinis, T. Rutherford, S. Freund, G. Winter, Nat. Chem. Biol. 5 (2009) 502-507. doi: 10.1038/nchembio.184
57. [57]
  D.E. Hacker, J. Hoinka, E.S. Iqbal, T.M. Przytycka, M.C.T. Hartman, ACS Chem. Biol. 12 (2017) 795-804. doi: 10.1021/acschembio.6b01006
58. [58]
  N. Bionda, R. Fasan, ChemBioChem 16 (2015) 2011-2016. doi: 10.1002/cbic.201500179
59. [59]
  R.H. Kimura, A.T. Tran, J.A. Camarero, Angew. Chem. Int. Ed. 118 (2006) 987-990. doi: 10.1002/ange.200503882
60. [60]
  S. Luckett, R.S. Garcia, J.J. Barker, et al., J. Mol. Biol. 290 (1999) 525-533.
61. [61]
  Y. Sako, J. Morimoto, H. Murakami, H. Suga, J. Am. Chem. Soc. 130 (2008) 7232-7234. doi: 10.1021/ja800953c
62. [62]
  S. Wada, S. Matsunaga, N. Fusetani, S. Watabe, Mar. Biotechnol. 1 (1999) 337-341.
63. [63]
  O. Potterat, K. Wagner, G. Gemmecker, et al., J. Nat. Prod. 67 (2004) 1528-1531. doi: 10.1021/np040093o
64. [64]
  R.I. Lehrer, A.M. Cole, M.E. Selsted, J. Biol. Chem. 287 (2012) 27014-27019. doi: 10.1074/jbc.R112.346098
65. [65]
  G.J. Kim, X. Li, S.H. Kim, et al., Org. Lett. 20 (2018) 7539-7543. doi: 10.1021/acs.orglett.8b03293
66. [66]
  S.B. Keysar, N. Gomes, B. Miller, et al., Cancer Res. 80 (2020) 1183-1198. doi: 10.1158/0008-5472.can-19-3232
67. [67]
  J. Kobayashi, H. Suzuki, K. Shimbo, K. Takeya, H. Morita, J. Org. Chem. 66 (2001) 6626-6633.
68. [68]
  H. Morita, K. Shimbo, H. Shigemori, J. Kobayashi, Bioorg. Med. Chem. Lett. 10 (2000) 469-471.
69. [69]
  Y. Qiu, M. Taichi, N. Wei, et al., J. Med. Chem. 60 (2017) 504-510. doi: 10.1021/acs.jmedchem.6b01011
70. [70]
  T. Durek, Q. Kaas, A.M. White, et al., J. Med. Chem. 64 (2021) 9906-9915. doi: 10.1021/acs.jmedchem.1c00095
71. [71]
  M.R.U. Karim, Y. In, T. Zhou, et al., Org. Lett. 23 (2021) 2109-2113. doi: 10.1021/acs.orglett.1c00210
72. [72]
  T. Miyata, F. Tokunaga, T. Yoneya, et al., J. Biochem. 106 (1989) 663-668. doi: 10.1093/oxfordjournals.jbchem.a122913
73. [73]
  G. Bennett, R. Lutz, P. Park, H. Harrison, K. Lee, Cancer Res. 77 (13_Supplement) (2017) 1167. doi: 10.1158/1538-7445.am2017-1167
74. [74]
  H. Sato, T. Takino, Y. Okada, et al., Nature 370 (1994) 61-65.
75. [75]
  K. Zarrabi, A. Dufour, J. Li, et al., J. Biol. Chem. 286 (2011) 33167-33177.
76. [76]
  U. Banerji, N. Cook, T.J. Evans, et al., J. Clin. Oncol. 36 (15_Supplement) (2018) TPS2610-TPS2610.
77. [77]
  P. Hart, P. Hommen, A. Noisier, et al., Angew. Chem. Int. Ed. 60 (2021) 1813-1820. doi: 10.1002/anie.202009749
78. [78]
  M. Rigby, P. Beswick, G. Mudd, et al., Cancer Res. 79 (13_Supplement) (2019) 4479.
79. [79]
  P. Upadhyaya, J. Kristensson, J. Lahdenranta, et al., J. Med. Chem. 65 (2022) 9858-9872. doi: 10.1021/acs.jmedchem.2c00505
80. [80]
  K.P. Papadopoulos, A. Dowlati, A. Dickson, et al., J. Clin. Oncol. 40 (2022) TPS2689. doi: 10.1200/jco.2022.40.16_suppl.tps2689
81. [81]
  J.A. Wells, C.L. McClendon, Nature 450 (2007) 1001-1009. doi: 10.1038/nature06526
82. [82]
  S. Guardiola, J. Seco, M. Varese, et al., ChemBioChem 19 (2018) 76-84. doi: 10.1002/cbic.201700519
83. [83]
  D.P. Teufel, G. Bennett, H. Harrison, et al., J. Med. Chem. 61 (2018) 2823-2836. doi: 10.1021/acs.jmedchem.7b01625
84. [84]
  N.G. Seidah, Z. Awan, M. Chrétien, M. Mbikay, Circ. Res. 114 (2014) 1022-1036.
85. [85]
  M.S. Sabatine, R.P. Giugliano, A.C. Keech, et al., N. Engl. J. Med. 376 (2017) 1713-1722. doi: 10.1056/NEJMoa1615664
86. [86]
  M. Szarek, H.D. White, G.G. Schwartz, et al., J. Am. Coll. Cardiol. 73 (2019) 387-396.
87. [87]
  C. Alleyne, R.P. Amin, B. Bhatt, et al., J. Med. Chem. 63 (2020) 13796-13824. doi: 10.1021/acs.jmedchem.0c01084
88. [88]
  T.J. Tucker, M.W. Embrey, C. Alleyne, et al., J. Med. Chem. 64 (2021) 16770-16800. doi: 10.1021/acs.jmedchem.1c01599
89. [89]
  K. Sakamoto, R. Koyama, Y. Kamada, M. Miwa, A. Tani, Biochem. Biophys. Res. Commun. 503 (2018) 1973-1979.
90. [90]
  A. Angelini, L. Cendron, S. Chen, et al., ACS Chem. Biol. 7 (2012) 817-821. doi: 10.1021/cb200478t
91. [91]
  Y. Luo, J.A. Schofield, Z. Na, et al., Cell Chem. Biol. 28 (2021) 463-474.
92. [92]
  I.R. Rebollo, C. Heinis, Methods. 60 (2013) 46-54.
93. [93]
  N. Machida, D. Takahashi, Y. Ueno, et al., J. Biol. Chem. 169 (2021) 295-302. doi: 10.1093/jb/mvaa130
94. [94]
  M. Plessner, R. Grosse, Curr. Opin. Cell Biol. 56 (2019) 1-6.
95. [95]
  V. Hurst, K. Shimada, S.M. Gasser, Trends Cell Biol. 29 (2019) 462-476.
96. [96]
  C.P. Caridi, M. Plessner, R. Grosse, I. Chiolo, Nat. Cell Biol. 21 (2019) 1068-1077. doi: 10.1038/s41556-019-0379-1
97. [97]
  M. Moreira, A. Ruggiero, E. Iaccarino, et al., Int. J. Biol. Macromol. 182 (2021) 1455-1462.
98. [98]
  Y. Li, G. Cai, S. Yuan, et al., Am. J. Transl. Res. 7 (2015) 120.
99. [99]
  I. Di Bonaventura, X. Jin, R. Visini, et al., Chem. Sci. 8 (2017) 6784-6798.
100. [100]
  T. Ikenoue, F.A. Aprile, P. Sormanni, M. Vendruscolo, Front. Neurosci. 15 (2021) 151.
101. [101]
  R. Tang, Y. Song, M. Shi, et al., Bioconjug. Chem. 32 (2021) 2173-2183. doi: 10.1021/acs.bioconjchem.1c00366
1. [1]
  Min Fu , Ruihan Wang , Wenqiang Liu , Sen Zhou , Chunhong Zhong , Yaohao Li , Pan He , Xin Li , Shiying Shang , Zhongping Tan . Improved one-pot protein synthesis enabled by a more precise assessment of peptide arylthioester reactivity. Chinese Chemical Letters, 2025, 36(7): 110542-. doi: 10.1016/j.cclet.2024.110542
2. [2]
  Lihua Mo , Hang Wu , Yu Zhang , Tengyan Xu , Yuanzhi Zhong , Zhimou Yang . A dissipative hydrogel formed by peptide-carbon dioxide interaction. Chinese Chemical Letters, 2026, 37(11): 112247-. doi: 10.1016/j.cclet.2025.112247
3. [3]
  Shulei Hu , Yu Zhang , Xiong Xie , Luhan Li , Kaixian Chen , Hong Liu , Jiang Wang . Rh(Ⅲ)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks. Chinese Chemical Letters, 2024, 35(8): 109408-. doi: 10.1016/j.cclet.2023.109408
4. [4]
  Dong-Fang Jiang , Fei Zeng , Rong-Nan Yi , Wei-Min He . Three-component synthesis of β-acyloxyl alkenyl amides for carboxylic acid/amino acid activation toward peptide and carboxylic acid derivatives synthesis. Chinese Chemical Letters, 2026, 37(7): 112488-. doi: 10.1016/j.cclet.2026.112488
5. [5]
  Chen Li , Ziyuan Zhao , Shouyun Yu . Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides. Chinese Chemical Letters, 2024, 35(6): 109128-. doi: 10.1016/j.cclet.2023.109128
6. [6]
  Xinwei Hu , Yong Zeng , Jiongdong Ma , Han Diao , Fei-Xiao Chen , Mu Chen , Shou-Kun Zhang , Chengzhi Jin , Shao-Fei Ni , Zhixiong Ruan . Electrochemical selenylation of tyrosine oligopeptides to benzo[b]furan-functionalized peptides. Chinese Chemical Letters, 2026, 37(3): 111928-. doi: 10.1016/j.cclet.2025.111928
7. [7]
  Dake Liu , Shuyan Liu , Fanlei Hu , Zhongtang Li , Zhongjun Li . N-Glycosylated type Ⅱ collagen peptides as therapeutic saccharide vaccines for rheumatoid arthritis. Chinese Chemical Letters, 2024, 35(5): 108762-. doi: 10.1016/j.cclet.2023.108762
8. [8]
  Jian Li , Jinjin Chen , Qi-Long Hu , Zhen Wang , Xiao-Feng Xiong . Recent progress of chemical methods for lysine site-selective modification of peptides and proteins. Chinese Chemical Letters, 2025, 36(5): 110126-. doi: 10.1016/j.cclet.2024.110126
9. [9]
  Xiao Tang , Erik V. Van der Eycken , Liangliang Song . Transition metal-catalyzed C-H activation/annulation for the construction of unnatural amino acids and peptides. Chinese Chemical Letters, 2026, 37(2): 111678-. doi: 10.1016/j.cclet.2025.111678
10. [10]
  Shu Li , Yuanyuan Tang , Xiaojing Liu , Shibo Song , Baokang Zhu , Min Chang , Yali Peng . Achieving enhancing endosome escape of Tat47-57-derived stapled peptides through decafluorobiphenyl bridge. Chinese Chemical Letters, 2026, 37(4): 111278-. doi: 10.1016/j.cclet.2025.111278
11. [11]
  Jingrong Huang , Xin Ding , Zihan Lin , Yu Lin , Yongqi Liao , Wang Gu , Fa-Jie Chen , Fen-Er Chen . Bromo nitrile oxide-mediated disulfide formation and capping of N-terminal cysteine in peptides. Chinese Chemical Letters, 2026, 37(6): 111715-. doi: 10.1016/j.cclet.2025.111715
12. [12]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628
13. [13]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
14. [14]
  Juan Tao , Jinlong Yang , Mengyu Zhao , Quangang Zhu , Zhongjian Chen , Jianping Qi . Emerging trends in permeation-enhancing technologies for oral peptide delivery. Chinese Chemical Letters, 2026, 37(3): 111170-. doi: 10.1016/j.cclet.2025.111170
15. [15]
  Ying Li , Long-Jie Wang , Yong-Kang Zhou , Jun Liang , Bin Xiao , Ji-Shen Zheng . An improved installation of 2-hydroxy-4-methoxybenzyl (iHmb) method for chemical protein synthesis. Chinese Chemical Letters, 2024, 35(5): 109033-. doi: 10.1016/j.cclet.2023.109033
16. [16]
  Wen Su , Siying Liu , Qingfu Zhang , Zhongyan Zhou , Na Wang , Lei Yue . Temperature-controlled electrospray ionization tandem mass spectrometry study on protein/small molecule interaction. Chinese Chemical Letters, 2025, 36(5): 110237-. doi: 10.1016/j.cclet.2024.110237
17. [17]
  Kun Shang , Yinghua Lv , Yibo Yang , Senyu Yang , Zelong Chen , Ke Yang , Cong Li , Shuang Chao , Yuchao Lu , Yuxin Pei , Zhichao Pei . "Dual sweet" supramolecular glycosyl-nanoproteins based on carbohydrate-protein interaction for targeted drug delivery in vivo. Chinese Chemical Letters, 2026, 37(7): 111798-. doi: 10.1016/j.cclet.2025.111798
18. [18]
  Rui Wang , He Qi , Haijiao Zheng , Qiong Jia . Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment. Chinese Chemical Letters, 2024, 35(7): 109215-. doi: 10.1016/j.cclet.2023.109215
19. [19]
  Cheng-Yan Wu , Yi-Nan Gao , Zi-Han Zhang , Rui Liu , Quan Tang , Zhong-Lin Lu . Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages. Chinese Chemical Letters, 2024, 35(11): 109649-. doi: 10.1016/j.cclet.2024.109649
20. [20]
  Shaofeng Gong , Zi-Wei Deng , Chao Wu , Wei-Min He . Stabilized carbon radical-mediated three-component functionalization of amino acid/peptide derivatives. Chinese Chemical Letters, 2025, 36(5): 110936-. doi: 10.1016/j.cclet.2025.110936

Get Citation

PDF

XML

Metrics

PDF Downloads(47)
Abstract views(3933)
HTML views(215)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142