Citation: Dan Ouyang, Zhihua Fu, Guorong Li, Chao Zhong, Jiahao Yuan, Huan Huang, Juan Lin, Gang Xu, Zian Lin. Metal-organic framework nanofilm enhances serum metabolic profiles for diagnosis and subtype of cardiovascular disease[J]. Chinese Chemical Letters, ;2023, 34(6): 107992. doi: 10.1016/j.cclet.2022.107992 shu

Metal-organic framework nanofilm enhances serum metabolic profiles for diagnosis and subtype of cardiovascular disease

Dan Ouyang ^a ,
Zhihua Fu ^b ,
Guorong Li ^a ,
Chao Zhong ^a ,
Jiahao Yuan ^a ,
Huan Huang ^a ,
Juan Lin ^c ,
Gang Xu ^{b, *,} ,
Zian Lin ^{a, *,}

a.
Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, China
b.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (CAS), Fuzhou 350002, China
c.
Department of Cardiology, Fujian Provincial Governmental Hospital, Fuzhou 350003, China

gxu@fjirsm.ac.cn

zianlin@fzu.edu.cn

Received Date: 13 July 2022
Revised Date: 24 October 2022
Accepted Date: 7 November 2022
Available Online: 15 November 2022

Figures(5)

Cardiovascular disease (CVD) is a global health problem and is thought to be responsible for almost half of all deaths in the world. Nevertheless, currently available diagnostic methods for CVD are strongly depended on clinical observation and monitoring, which commonly result in false diagnosis. Herein, an attractive strategy of a metal-organic framework (MOF) nanofilm-based laser desorption/ionization mass spectrometry (LDI-MS) was developed for enhancing serum metabolic profiling, which could provide precise diagnosis and molecular subtyping of CVD. The porous MOF nanofilm fabricated on indium-tin oxide (ITO) glass possessed enhanced ionization efficiency and size-exclusion effect, which endowed it as substrate with high sensitivity and selectivity for serum metabolites. Furthermore, the MOF nanofilm with uniform surface and high orientation provided high-quality and high-reproducibility serum metabolic profiles (SMPs) without any tedious pretreatment. Further analysis of extracted serum metabolic fingerprints could successfully distinguish patients with CVD from healthy controls and also differentiate two major subtypes of CVD. This work not only extends the application of MOF nanofilm as an attractive MS probe, but also provide an alternative way for precise diagnosis of CVD in molecular level.
- Cardiovascular disease,
- Mass spectrometry,
- Metal-organic framework nanofilm,
- Metabolites,
- Precise diagnosis
1. [1]
  H. Clark, The Lancet 381 (2013) 510–511. doi: 10.1016/S0140-6736(13)60058-6
2. [2]
  F. Paneni, C. Diaz Cañestro, P. Libby, et al., J. Am. Coll. Cardiol. 69 (2017) 1952–1967.
3. [3]
  J.R. Ussher, S. Elmariah, R.E. Gerszten, et al., J. Am. Coll. Cardiol. 68 (2016) 2850–2870. doi: 10.1016/j.jacc.2016.09.972
4. [4]
  Z. Wang, Q. Zhang, J. Xiong, et al., IEEE Sens. J. 17 (2017) 5581–5588. doi: 10.1109/JSEN.2017.2726011
5. [5]
  C.H. Johnson, J. Ivanisevic, G. Siuzdak, Nat. Rev. Mol. Cell Biol. 17 (2016) 451–459. doi: 10.1038/nrm.2016.25
6. [6]
  Z. Liu, D. Pouli, C.A. Alonzo, et al., Sci. Adv. 4 (2018) eaap9302. doi: 10.1126/sciadv.aap9302
7. [7]
  J. Whitburn, S.R. Rao, E.V. Morris, et al., Sci. Adv. 8 (2022) eabf9096. doi: 10.1126/sciadv.abf9096
8. [8]
  J. Yang, R. Wang, L. Huang, et al., Angew. Chem. Int. Ed. 59 (2020) 1703–1710. doi: 10.1002/anie.201913065
9. [9]
  H. Taegtmeyer, M.E. Young, G.D. Lopaschuk, et al., Circ. Res. 118 (2016) 1659–1701. doi: 10.1161/RES.0000000000000097
10. [10]
  M. Zhang, L. Huang, J. Yang, et al., Adv. Sci. 8 (2021) 2101333. doi: 10.1002/advs.202101333
11. [11]
  W. Lu, X. Su, M.S. Klein, et al., Annu. Rev. Biochem. 86 (2017) 277–304. doi: 10.1146/annurev-biochem-061516-044952
12. [12]
  Y. Li, M. Bouza, C. Wu, et al., Nat. Commun. 11 (2020) 5625. doi: 10.1038/s41467-020-19444-y
13. [13]
  X. Sun, L. Huang, R. Zhang, et al., ACS Cent. Sci. 4 (2018) 223–229. doi: 10.1021/acscentsci.7b00546
14. [14]
  C. Yang, H. Yu, X. Hu, et al., Adv. Funct. Mater. 31 (2021) 2105478. doi: 10.1002/adfm.202105478
15. [15]
  R. Li, Y. Zhou, C. Liu, et al., Angew. Chem. Int. Ed. 60 (2021) 12504–12512. doi: 10.1002/anie.202101007
16. [16]
  L. Huang, L. Wang, X. Hu, et al., Nat. Commun. 11 (2020) 3556. doi: 10.1038/s41467-020-17347-6
17. [17]
  M.S. Rana, L. Xu, J. Cai, et al., Small 16 (2020) 2003902. doi: 10.1002/smll.202003902
18. [18]
  V. Vedarethinam, L. Huang, M. Zhang, et al., Adv. Funct. Mater. 30 (2020) 2002791. doi: 10.1002/adfm.202002791
19. [19]
  Z. Lin, Z. Cai, Mass Spectrom. Rev. 37 (2018) 681–696. doi: 10.1002/mas.21558
20. [20]
  A.Y. Lim, J. Ma, Y.C.F. Boey, Adv. Mater. 24 (2012) 4211–4216. doi: 10.1002/adma.201200027
21. [21]
  L.Z. Samarah, A. Vertes, View 1 (2020) 20200063. doi: 10.1002/VIW.20200063
22. [22]
  Y.T. Lai, K. Kandasamy, Y.C. Chen, Anal. Chem. 93 (2021) 7310–7316. doi: 10.1021/acs.analchem.1c00878
23. [23]
  B. Gulbakan, E. Yasun, M.I. Shukoor, et al., J. Am. Chem. Soc. 132 (2010) 17408–17410. doi: 10.1021/ja109042w
24. [24]
  S. Li, J. Liu, J. Sun, et al., Chin. Chem. Lett. 32 (2021) 62–65. doi: 10.1016/j.cclet.2020.09.026
25. [25]
  J. Wei, J.M. Buriak, G. Siuzdak, Nature 399 (1999) 243–246. doi: 10.1038/20400
26. [26]
  S.A. Iakab, P. Rafols, M. García-Altares, et al., Adv. Funct. Mater. 29 (2019) 1903609. doi: 10.1002/adfm.201903609
27. [27]
  S.A. Stopka, C. Rong, A.R. Korte, et al., Angew. Chem. Int. Ed. 55 (2016) 4482–4486. doi: 10.1002/anie.201511691
28. [28]
  J.A. McLean, K.A. Stumpo, D.H. Russell, J. Am. Chem. Soc. 127 (2005) 5304–5305. doi: 10.1021/ja043907w
29. [29]
  Y. Wang, K. Zhang, T. Tian, et al., ACS Appl. Mater. Interfaces 13 (2021) 4886–4893. doi: 10.1021/acsami.0c20944
30. [30]
  S.S. Yang, M.Y. Shi, Z.R. Tao, et al., Anal. Bioanal. Chem. 411 (2019) 4509–4522. doi: 10.1007/s00216-019-01876-1
31. [31]
  K. Hu, Y. Lv, F. Ye, et al., Anal. Chem. 91 (2019) 6353–6362. doi: 10.1021/acs.analchem.9b01376
32. [32]
  Q. Sun, C. Gao, W. Ma, et al., Microchim. Acta 187 (2020) 370. doi: 10.1007/s00604-020-04340-5
33. [33]
  L. Huang, J. Wan, X. Wei, et al., Nat. Commun. 8 (2017) 220. doi: 10.1038/s41467-017-00220-4
34. [34]
  S.A. Iakab, P. Ràfols, M. Tajes, et al., ACS Nano 14 (2020) 6785–6794. doi: 10.1021/acsnano.0c00201
35. [35]
  C. Pei, C. Liu, Y. Wang, et al., Angew. Chem. 132 (2020) 10923–10927. doi: 10.1002/ange.202001135
36. [36]
  X. Li, A.S. Kulkarni, X. Liu, et al., Small Methods 5 (2021) 2001001. doi: 10.1002/smtd.202001001
37. [37]
  J.R. Li, R.J. Kuppler, H.C. Zhou, Chem. Soc. Rev. 38 (2009) 1477–1504. doi: 10.1039/b802426j
38. [38]
  H. Dou, M. Xu, B. Wang, et al., Chem. Soc. Rev. 50 (2021) 986–1029. doi: 10.1039/D0CS00552E
39. [39]
  A. Schoedel, M. Li, D. Li, et al., Chem. Rev. 116 (2016) 12466–12535. doi: 10.1021/acs.chemrev.6b00346
40. [40]
  F. Mu, B. Dai, W. Zhao, et al., Chin. Chem. Lett. 31 (2020) 1773–1781. doi: 10.1016/j.cclet.2019.12.015
41. [41]
  D. Ouyang, Q. Zheng, H. Huang, et al., Anal. Chem. 93 (2021) 15573–15578. doi: 10.1021/acs.analchem.1c01743
42. [42]
  J. Lee, Y.K. Kim, D.H. Min, J. Am. Chem. Soc. 132 (2010) 14714–14717. doi: 10.1021/ja106276j
43. [43]
  M.S. Yao, X.J. Lv, Z.H. Fu, et al., Angew. Chem. Int. Ed. 56 (2017) 16510–16514. doi: 10.1002/anie.201709558
44. [44]
  K. Dreisewerd, Chem. Rev. 103 (2003) 395–426. doi: 10.1021/cr010375i
45. [45]
  A. Bhardwaj, J. Kaur, M. Wuest, et al., Nat. Commun. 8 (2017) 1. doi: 10.1038/s41467-016-0009-6
46. [46]
  M. Hmadeh, Z. Lu, Z. Liu, et al., Chem. Mater. 24 (2012) 3511–3513. doi: 10.1021/cm301194a
47. [47]
  R. Haldar, L. Heinke, C. Wöll, Adv. Mater. 32 (2020) 1905227. doi: 10.1002/adma.201905227
48. [48]
  J.P. Wang, Y. Wang, X. Guo, et al., Microchim. Acta 185 (2018) 175. doi: 10.1007/s00604-017-2627-z
49. [49]
  Z. Lin, W. Bian, J. Zheng, et al., Chem. Commun. 51 (2015) 8785–8788. doi: 10.1039/C5CC02495A
50. [50]
  C.P. Fu, S. Lirio, W.L. Liu, et al., Anal. Chim. Acta 888 (2015) 103–109. doi: 10.1016/j.aca.2015.07.029
51. [51]
  J. Wu, D. Ouyang, Y. He, et al., ACS Appl. Mater. Interfaces 11 (2019) 38255–38264. doi: 10.1021/acsami.9b11100
52. [52]
  G. Han, Q. Zeng, Z. Jiang, et al., Talanta 164 (2017) 355–36. doi: 10.1016/j.talanta.2016.11.044
53. [53]
  X. Song, X. Wang, Y. Li, et al., Angew. Chem. Int. Ed. 59 (2020) 1118–1123. doi: 10.1002/anie.201911543
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