Citation: Huihui Hu, Zhen Zhang, Yifen Fang, Lei Chen, Jun Wu. Therapeutic poly(amino acid)s as drug carriers for cancer therapy[J]. Chinese Chemical Letters, ;2023, 34(6): 107953. doi: 10.1016/j.cclet.2022.107953 shu

Therapeutic poly(amino acid)s as drug carriers for cancer therapy

Huihui Hu ^{a, 1} ,
Zhen Zhang ^{a, 1} ,
Yifen Fang ^b ,
Lei Chen ^{a, *,} ,
Jun Wu ^{c, d, *,}

a.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
b.
Department of Cardiology, The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou 510120, China
c.
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China
d.
Division of Life Science, Hong Kong University of Science and Technology, Hong Kong 999077, China

chenlei59@mail.sysu.edu.cn

junwuhkust@ust.hk

Received Date: 4 August 2022
Revised Date: 20 October 2022
Accepted Date: 23 October 2022
Available Online: 29 October 2022

Figures(4)

As one of the top global health problems, the effective treatment of cancer is one of the most urgent clinical challenges. Currently, the main treatments for cancer include surgery, chemotherapy, radiotherapy, and gene therapy etc. Chemotherapy is one of the most commonly used treatments, however it has limitations such as highly toxic side effects and low drug utilization rate that limit its application. Gene therapy, as an emerging cancer treatment, has limitations such as drug instability, off-target effects and low internalization efficiency. Poly(amino acid)s carriers with good biocompatibility, degradability and multifunctionality as drug carriers have received much attention, as they can reduce the toxic side effects of chemotherapy, improve drug utilization, and enhance the internalization efficiency and utilization of gene drugs. However, little attention has been paid to the nature of the carriers themselves. This paper reviews the immunomodulatory, anti-inflammatory, antioxidant, internalization-promoting and apoptosis-promoting functions of poly(amino acid)s drug carriers in tumor therapy to provide a theoretical basis for different carrier-drug-adapted synergistic therapies.
- Poly(amino acid)s,
- Immunomodulatory,
- Antioxidant,
- Anti-inflammatory,
- Apoptosis-promoting
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沈阳化工大学材料科学与工程学院沈阳 110142